Plasma lipids relationship with results of Oral Glucose Challenge Test in pregnancy
-
Soraya Salehi Gargari
,
Sedigheh Hantoushzadeh
,
Mina Jafarabadi
,
Sedigheh Borna
,
Soghra Khazardoust
Abstract
Objective: This study aimed to evaluate the correlation between plasma lipid levels at first trimester of pregnancy and results of Oral Glucose Challenge Test (OGCT).
Materials and methods: In a cross - sectional descriptive analytic study, two hundred eligible primigravida women without history of Diabetes Mellitus referring to Vali-e-Asr Hospital were evaluated. Plasma levels of triglyceride and cholesterol were measured at first trimester of pregnancy and Oral Glucose Challenge Test was done for all women at 24th - 28th gestational week. Pre-pregnancy BMI, and plasma levels of triglyceride and cholesterol at first trimester of pregnancy were compared with the results of OGCT. Results were analyzed using SPSS version 14. p-values ≤ 0.05 was considered statistically significant.
Results: In 45 (22.5%) of the women OGCT was positive. Pre pregnancy BMI and the rate of positive result for OGCT were both correlated with the plasma levels of triglyceride and cholesterol at first trimester of pregnancy.
Conclusion: Plasma lipid levels in first trimester can predict the result of OGCT at 24- 28 weeks of pregnancy.
-Metzger B, Coustan DR . Summary and recommendations of the Fourth International Workshop-Conference on Gestational Diabetes Mellitus. The Organizing Committee. Diabetes Care 1998; 21 Suppl 2:B: 161-167.
-Engelgau MM, Herman WH, Smith PJ, German RR, Aubert RE. The epidemiology of diabetes and pregnancy in the U.S., 1988. Diabetes Care 1995; 18(7): 1029-1033.
-Langer O, Rodriguez DA, Xenakis EM, McFarland MB, Berkus MD, Arrendondo F. Intensified versus conventional management of gestational diabetes. Am J Obstet Gynecol 1994; 170: 1036-1046.
-Coustan D. Screening and diagnosis of gestational diabetes. Semin Perinatol 1994; 18(5): 407-413.
-Ben-Haroush A, Yogev Y,. Hod M. Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetes. Diabet Med 2004; 21: 103-113.
-Dandrow R, O'Sullivan JB. Obstetric hazards of gestational diabetes. Am J Obstet Gynecol 1966; 96(8): 1144-1147.
-Davis CL, Gutt M, Llabre MM, Marks JB, O'Sullivan MJ, Potter JE, et al. History of gestational diabetes, insulin resistance and coronary risk. J Diabetes Complications 1999 ; 13(4): 216-223.
-Krauss R . Lipids and lipoproteins in patients with type 2 diabetes. Diabetes Care 2004; 27: 1496-1504.
-Couch SC, Philipson EH, Bendel RB, Wijendran V, Lammi-Keefe CJ. Maternal and cord plasma lipid and lipoprotein concentrations in women with and without gestational diabetes mellitus. Predictors of birth weight? J Reprod Med 1998 ;43(9): 816-822.
-Bartha JL, Comino-Delgado R, Martinez-Del-Fresno P, Fernandez-Barrios M, Bethencourt I, Moreno-Corral L. Insulin-sensitivity index and carbohydrate and lipid metabolism in gestational diabetes. J Reprod Med 2000; 45(3): 185-189.
-Clark CJ , Qiu C, Amerman B, Porter B, Fineberg N, Aldasouqi S, et al, Gestational diabetes: should it be added to the syndrome of insulin resistance? Diabetes Care 1997; 20: 867-871.
-Bower J, Hadi H, Barakat HA. Plasma lipoprotein subpopulation distribution in Caucasian and African-American women with gestational diabetes. Diabetes Care 2001; 24: 169-171.
-Knopp R, Chapman M, Bergelin R, Wahl PW, Warth MR, Irvine S. Relationships of lipoprotein lipids to mild fasting hyperglycemia and diabetes in pregnancy. Diabetes Care 1980; 3: 416-420.
-Meyers-Seifer CH,. Vohr BR. Lipid levels in former gestational diabetic mothers. Diabetes Care 1996; 19: 1351-1356.
-de Arcos F, Castelo-Branco C, Casals E, Sanllehy C, Cararach V. Normal and gestational diabetic pregnancies. Lipids, lipoproteins and apolipoproteins. J Reprod Med 1998 ;43(2): 144-148.
-Vitoratos N, Kassanos D, Salamalekis E, Sirisratidis Ch, Baimacou E, Creatsas G. Maternal homocysteine levels and plasma lipids in gestational diabetes: is there any relationship? J Obstet Gynaecol. 2002; 22(4): 366-369.
-Koukkou E, Watts GF, C. Low. Plasma lipid, lipoprotein and apolipoprotein changes in gestational diabetes mellitus: a cross-sectional and prospective study. J Clin Pathol 1996; 49: 634-637.
-Toescu V, Nuttall S, Martin U, Nightingale P, Kendall MJ, Brydon P, et al. Changes in plasma lipids and markers of oxidative stress in normal pregnancy and pregnancies complicated by diabetes. Clin Sci 2004; 106: 93-98.
-Nolan C, Riley SF, Sheedy MT. Maternal plasma triglycercide, glucose tolerance, and neonatal birth weight ratio in pregnancy. Diabetes Care 1995; 18: 1550-1557.
-Montelongo A, Lasuncion MA, Pallardo LF, Herrera E, Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women. Diabetes 1992; 41: 1651-1659.
-Schaefer E, Audelin MC, McNamara JR, Shah PK, Taylor T, Daly JA, et al., Comparison of fasting and postprandial plasma lipoproteins in subjects with and without coronary heart disease. Am J Cardio 2001; 88: 1129-1133.
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| Issue | Vol 1, No 1 (September 2007) | |
| Section | Original Articles | |
| Keywords | ||
| Oral Glucose Challenge Test Plasma Triglyceride Body Mass Index | ||
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