Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 1 1 2007 03 15 24 28 Soraya Salehi Gargari Fetomaternal Unit, Urmia University of Medical Sciences. Urmia, Iran Sedigheh Hantoushzadeh Vali-e-Asr Reproductive Health Research Center, Medical Sciences/ University of Tehran,Iran Mina Jafarabadi Vali-e-Asr Reproductive Health Research Center, Medical Sciences/ University of Tehran,Iran Sedigheh Borna Vali-e-Asr Reproductive Health Research Center, Medical Sciences/ University of Tehran,Iran Soghra Khazardoust Vali-e-Asr Reproductive Health Research Center, Medical Sciences/ University of Tehran,Iran 2015 10 04 Objective: This study aimed to evaluate the correlation between plasma lipid levels at first trimester of pregnancy and results of Oral Glucose Challenge Test (OGCT). Materials and methods:  In a cross - sectional descriptive analytic study, two hundred eligible primigravida women without history of Diabetes Mellitus referring to Vali-e-Asr Hospital were evaluated. Plasma levels of triglyceride and cholesterol were measured at first trimester of pregnancy and Oral Glucose Challenge Test was done for all women at  24th - 28th gestational week. Pre-pregnancy BMI, and plasma levels of triglyceride and cholesterol at first trimester of pregnancy were compared with the results of OGCT. Results were analyzed using SPSS version 14. p-values ≤ 0.05 was considered statistically significant. Results: In 45 (22.5%) of the women OGCT was positive.  Pre pregnancy BMI and the rate of positive result for OGCT were both correlated with the plasma levels of triglyceride and cholesterol at first trimester of pregnancy. Conclusion: Plasma lipid levels in first trimester can predict the result of OGCT at 24- 28 weeks of pregnancy. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/5 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/5/5