Isolated Vaginal Neurofibroma Presenting as Vaginal Wall Cyst: A Rare Case Report With Review of Literature
Abstract
Neurofibromas commonly involve peripheral nervous system. Isolated neurofibroma of vagina is very rare tumor and usually associated with Von Recklinghausen’s disease. Vulva is the most frequent location of neurofibroma of genital tract followed by clitoris and labia. We present a rare case of neurofibroma of vaginal wall presented as vaginal cyst in a 52 year old female with no history of any other symptoms related to Recklinghausen’s disease. Excision biopsy was done and on the histopathological examination non-encapsulated, well circumscribed mass composed of spindle shaped cells with wavy nuclei and bland nuclear chromatin was noted. Immunohistochemistry revealed strong positivity with S-100.
Gordon MD, Weilert M, Ireland K. Plexiform neurofibromatosis involving the uterine cervix, endometrium, myometrium, and ovary. Obstet Gynecol 1996;88:699-701.
Burger PC, Scheithauer BW, Vogel FS. Surgical Pathology of the Nervous System and Its Covering vol 1, 4th edn. Philadelphia: Churchill Livingstone 2002: 594–611.
Tamer E, Yalein B, Alli N. Multiple nodular plexiformneurofibromas in a neurofibromatosis1 family: A familial tendency? A case report and review of the literature. Int J Dermatol 2003;42:357–8.
MouraliM, Hammedi N, Fekih C, Essoussi-Chikhaoui J, Binous N, Ben Zineb S, et al. Vaginal neurofibroma. Tunis Med 2009; 87: 411.
Yayli S, Bahadir S, Cim Sit G, Bozkaya H, Imamo˘Glu HI , Kul S. Coexistence of Mayer-Rokitansky-Kuster-Hauser syndrome and neurofibromatosis type. Am J Clin Dermatol 2008; 9: 57-60.
Baulies S, Cusidó MT, Grases PJ, Ubeda B, Pascual MA, Fábregas R. Neurofibroma of the vaginal wall. Clin Exp Obstet Gynecol 2008 ;35:140-3.
Sharma JB, Wadhwa L, Malhotra M, Arora R, Garg A, Singh S. Huge localized vaginal neurofibromatosis: An unusual cause of postmenopausal bleeding. J Obstet Gynaecol Res 2004; 30:96-9.
Eusebi V, Schönauer S. Pigmented vaginal neurofibroma. Minerva Ginecol 1974;24:265-70.
Gold BM. Neurofibromatosis of the bladder and vagina. Am J Obstet Gynecol 1972;113: 1055-6.
Drescher H, Herzog W.On neurofibromatosis of the vulva and vagina. Zentralbl Gynakol 1961; 83:743-50.
Marmey J, Lacroix A. [Recklinghausen disease and
pregnancy; cesarean section in vaginal neurofibromatosis]. Bull Fed Soc Gynecol Obstet Lang 1951; 3: 645-6.
Belvederi GD, PelusiG, Tosi P.Anatomo-clinical findings on a case of neurofibroma of the vagina. Riv Ital Ginecol 1974; 55: 403-11.
De Jorio A, Belfiore M. Rare case of vaginal localization in the course of Recklinghausen's disease. Rass Int Clin Ter 1970;50:105-13.
Stingl A. Contribution to the knowledge of primary neurofibroma of the vagina. Geburtshilfe Frauenheilkd 1963;23:766-70.
Norris JW, Cooper JR. Primary neurofibroma of the vagina; a case report. J Kans Med Soc 1950; 51: 128-30.
Iloki LH, Lefebvre G, Dolo A, Darbois Y. A case of neurofibroma of the vagina. Review of the literature . J Gynecol Obstet Biol Reprod 1991;20:507-10.
| Files | ||
| Issue | Vol 10, No 1 (March 2016) | |
| Section | Case Reports | |
| Keywords | ||
| Vaginal Cyst Neurofibroma Histopathology | ||
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