Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 10 1 2016 05 15 49 51 EN Sarita Nibhoria Department of Pathology, Guru Gobind Singh Medical College AND Hospital, Faridkot, Punjab, India Kanwardeep Kaur Tiwana Department of Pathology, Guru Gobind Singh Medical College AND Hospital, Faridkot, Punjab, India Manmeet Kaur Department of Pathology, Guru Gobind Singh Medical College AND Hospital, Faridkot, Punjab, India Richa Phutela Department of Pathology, Guru Gobind Singh Medical College AND Hospital, Faridkot, Punjab, India 2016 01 06 2016 02 21 Neurofibromas commonly involve peripheral nervous system. Isolated neurofibroma of vagina is very rare tumor and usually associated with Von Recklinghausen’s disease. Vulva is the most frequent location of neurofibroma of genital tract followed by clitoris and labia. We present a rare case of neurofibroma of vaginal wall presented as vaginal cyst in a 52 year old female with no history of any other symptoms related to Recklinghausen’s disease. Excision biopsy was done and on the histopathological examination non-encapsulated, well circumscribed mass composed of spindle shaped cells with wavy nuclei and bland nuclear chromatin was noted. Immunohistochemistry revealed strong positivity with S-100. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/375 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/375/349