Original Articles

Exploring the Genetic Influence of Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) on Inflammatory Biomarkers in Endometriosis Progression

Abstract

Objective: Investigating the genetic influence of Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) on key inflammatory biomarkers-Interleukin-1β, Interleukin-6, and high-sensitivity C-reactive protein (hsCRP) and to evaluate their association with disease progression in endometriosis. Specifically, this study aims to (i) assess differential expression of PTPN22 in cases versus controls, (ii) examine correlations between PTPN22 expression and inflammatory markers, and (iii) determine the predictive value of these biomarkers using ROC curve analysis.
Materials and methods: This study involved 150 women with endometriosis and 150 matched controls. Blood samples were analyzed for inflammatory markers (IL-6, IL-1β, hsCRP) using ELISA and PTPN22 gene expression by real-time PCR. Statistical analyses were conducted using Stata 17.0, and ethical approval (01/2022/IECG) and informed consent was obtained.
Results: PTPN22 expression was higher in endometriosis cases (p = 0.0001), suggesting a role in disease pathophysiology. ROC analysis showed moderate predictive accuracy (AUC = 0.63). Among the inflammatory markers, hs-CRP was the most diagnostic, followed by IL-6 and IL-1β, with stronger positive correlations observed in the endometriosis group.
Conclusion: These findings highlight the translational relevance of PTPN22 and hsCRP as candidate biomarkers for early detection and risk stratification in endometriosis, underscoring the interplay between genetic susceptibility and inflammatory signaling in its pathogenesis.

 

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IssueVol 19, No 4 (December 2025) QRcode
SectionOriginal Articles
Keywords
Endometriosis Inflammatory Biomarkers Immune Regulation Pro-Inflammatory Cytokines Protein Tyrosine Phosphatase Non-Receptor Type 22
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How to Cite
1.
Sreekumar P, Chandrahausan A, Josephine A, Dhandapani P, Joseph B, Mullukalayil Joseph S, Jayasree Sasidharan Nair J, Roy Divakaran D. Exploring the Genetic Influence of Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) on Inflammatory Biomarkers in Endometriosis Progression. J Family Reprod Health. 2025;19(4):272-279.