Original Articles

Comparative Analytical Study of Dinoprostone Gel and Hyaluronidase Injection for Induction of Labour in Term Primigravida in Tertiary Rural Medical Centre of Western Uttar Pradesh


Objective: To compare the efficacy of intracervical dinoprostone gel and hyaluronidase injection for induction of labour in term primigravida.
Materials and methods: This is a hospital based analytical prospective interventional study conducted in a rural tertiary care centre over a period of 18 months.  A total of 70 patients who required induction of labour for one or another reason with Bishop score of less than 6 were included in the study. All the cases were randomly divided into two groups, Group A received dinoprostone gel and Group B received hyaluronidase injection. Chi square test & unpaired T test were applied for statistical analysis.
Results: Time interval from induction to active phase of labour was comparatively shorter in group A than in group B (10.74 ± 6.17 vs 15.94 ± 7.1) and the difference was significant (p= 0.001). Time interval from induction to delivery time was comparatively shorter in group A than group B (14.84 ± 8.86 vs 21.33 ± 7.86) and difference was significant (P= 0.009). Maternal complications were more common in group A as compared to group B.
Conclusion: This study showed that labour could be accelerated significantly by intracervical injection of hyaluronidase. Hyaluronidase injection has less maternal and fetal side-effects as compared to dinoprostone gel and can be a good choice for induction of labour.

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IssueVol 16, No 3 (September 2022) QRcode
SectionOriginal Articles
DOI https://doi.org/10.18502/jfrh.v16i3.10577
Induction of Labour Dinoprostone Gel Intracervical Hyaluronidase Injection Bishop Score

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How to Cite
Swaroop N, Bano S, Vishwakarma S, Mittal N, Kanti V, Gupta V, Shree P. Comparative Analytical Study of Dinoprostone Gel and Hyaluronidase Injection for Induction of Labour in Term Primigravida in Tertiary Rural Medical Centre of Western Uttar Pradesh. J Family Reprod Health. 2022;16(3):177-182.