Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 16 3 2022 09 06 177 182 Neelam Swaroop T.S. Mishra Medical College Lucknow, Uttar Pradesh, India Shaheen Bano Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India Soniya Vishwakarma Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India Nupur Mittal Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India Vaibhav Kanti Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India Vandana Gupta Rajarshi Dashrath Autonomous State Medical College, Ayodhya, Uttar Pradesh, India Pragya Shree Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India 2022 02 21 2022 08 09 Objective: To compare the efficacy of intracervical dinoprostone gel and hyaluronidase injection for induction of labour in term primigravida. Materials and methods: This is a hospital based analytical prospective interventional study conducted in a rural tertiary care centre over a period of 18 months.  A total of 70 patients who required induction of labour for one or another reason with Bishop score of less than 6 were included in the study. All the cases were randomly divided into two groups, Group A received dinoprostone gel and Group B received hyaluronidase injection. Chi square test & unpaired T test were applied for statistical analysis. Results: Time interval from induction to active phase of labour was comparatively shorter in group A than in group B (10.74 ± 6.17 vs 15.94 ± 7.1) and the difference was significant (p= 0.001). Time interval from induction to delivery time was comparatively shorter in group A than group B (14.84 ± 8.86 vs 21.33 ± 7.86) and difference was significant (P= 0.009). Maternal complications were more common in group A as compared to group B. Conclusion: This study showed that labour could be accelerated significantly by intracervical injection of hyaluronidase. Hyaluronidase injection has less maternal and fetal side-effects as compared to dinoprostone gel and can be a good choice for induction of labour. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2043