An Unusual Case of Genital Lesion: A Vulvar Syringoma
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Abstract
Objective: Syringoma is a benign adnexal neoplasm of sweat gland, usually presenting as extra-genital lesions, while vulvar localization is rare. Moreover, syringoma is an uncommon vulvar neoplasms.
Case report: A 44-year-old woman with previous diagnosis of duodenal gastrointestinal stromal tumour, underwent a local surgical excision for an isolated, painful, vulvar lesion. The specimen was submitted for histological examination. A vulvar syringoma was diagnosed.
Conclusion: We describe this case according on its rarity and atypical presentation as well; therefore, vulvar neoplasms encompass many differential diagnoses, among which the incidence rate of syringoma is very low. Although its rarity, syringoma should be included among the differential diagnosis for vulvar neoplasm.
Carneiro SJ, Gardner HL, Knox JM. Syringoma. Three cases with vulvar involvement. Obstet Gynecol 1972; 39:95-9.
2. Elder D, Elenitsas R, Ragsdale BD. Tumors of the epidermal appendages. Lever’s histopathology of the skin. Lippincott-Raven 1997; 778-9.
3. Shelley WB, Wood MG. Occult syringomas of scalp associated with progressive hair loss. Arch Dermatol 1980; 116:843-4.
4. Tagami H, Inoue F, Yamada M, Egami K. Syringoma of the forehead. Int J Dermatol 1983; 22:113-4.
5. Van den Broek H, Lundquist CD. Syringomas of the upper extremities with onset in the sixth decade. J Am Acad Dermatol 1982; 6:534-6.
6. Baker GM, Selim MA, Hoang MP. Vulvar adnexal lesions: a 32-year, single institution review from Massachusetts General Hospital. Arch Pathol Lab Med 2013; 137:1237-46.
7. Kaposi, M. Hebra diseases of the skin. Lymphangioma Tuberosum Multiplex. London, the New Sydendham Society. 1874; 3:386.
8. Biesiadeki, A. Anatomischen Tuberosum multiplex: untersuchungen aus der Pathologisch Lymphangioma Institute in Krakau. Vienna: Wilhelm Braumuller 1972; 2.
9. Van der Putte SC. Anogenital “sweat” glands. Histology and pathology of a gland that may mimic mammary glands. Am J Dermatopathol 1991; 13:557-67.
10. Thomas J, Majmudar B, Gorelkin k. Syringoma localized to the vulva. Arch Dermatol 1979; 115:95-6.
11. Huang YH, Chuang YH, Kuo T, Yang LC, Hong HS. Vulvar syringoma: a clinicopathologic and immunohistologic study of 18 patients and results of treatment J Am Acad Dermatol 2003; 48:735-9.
12. Young AW, Herman EW, Tovell HM. Syringoma of the vulva: incidence, diagnosis. and cause of pruritus. Obstet. Gynecol. 1980; 55:515-8.
13. Carter J, Elliot P. Syringoma: an unusual cause of pruritus vulvae. Aust N Z J Obstet Gynaecol 1990; 30:382-3.
14. Wallace ML, Smoller BR. Progesterone receptor positivity supports hormonal control of syringomas.
J Cutan Pathol 1995; 22:442-5.
15. Goltz RW. Syringoma (syringocystadenoma). Harper and Row; 1976, 22-24.
16. Turan, C, Ugur M, Kutluay L, Kukner S, Dabakoglu T, Aydogdu T, et. Vulvar syringoma exacerbated during pregnancy. Eur J Obstet Gynecol Reprod Biol 1996; 64:141-2.
17. Yorganci A, Kale A, Dunder I, Ensar A, Sertcelik A. Vulvar syringoma showing progesterone receptor positivity. BJOG 2000; 107:292-4.
18. Ghatt HJ, Proia AD, Tsoy EA. Malignant syringoma of the eyelid. Opthalmology. 1984; 91:987-90.
19. Perez-Bustillo A, Ruiz-Gonzalez I, Delgado S, Alonso T, Ingelmo J. Vulvar syringoma: a rare cause of vulvar pruritus. Actas Dermosifiliogr 2008; 99:580-1.
20. Isaacson D, Turner ML. Localized vulvar syringomas. J Am Acad Dermatol 1979; 1:352-7.
21. Pincus SH, McKay M. Disorders of the female genitalia. Dermatology in General Medicine. New York: McGraw-Hill 1993, 1463-81.
22. Brown SM, Freeman RG. Syringoma limited to the vulva. Arch. Dermatol 1971; 104:331.
23. Belardi MG, Maglione MA, Vighi S, Di Paola GR. Syringoma of the vulva: a case report. J Reprod Med 1994; 39:957-9.
24. Di Lemia V, Bisighini G. Localized vulvar syringomas. Pediatr Dermatol 1996; 13:80-1.
2. Elder D, Elenitsas R, Ragsdale BD. Tumors of the epidermal appendages. Lever’s histopathology of the skin. Lippincott-Raven 1997; 778-9.
3. Shelley WB, Wood MG. Occult syringomas of scalp associated with progressive hair loss. Arch Dermatol 1980; 116:843-4.
4. Tagami H, Inoue F, Yamada M, Egami K. Syringoma of the forehead. Int J Dermatol 1983; 22:113-4.
5. Van den Broek H, Lundquist CD. Syringomas of the upper extremities with onset in the sixth decade. J Am Acad Dermatol 1982; 6:534-6.
6. Baker GM, Selim MA, Hoang MP. Vulvar adnexal lesions: a 32-year, single institution review from Massachusetts General Hospital. Arch Pathol Lab Med 2013; 137:1237-46.
7. Kaposi, M. Hebra diseases of the skin. Lymphangioma Tuberosum Multiplex. London, the New Sydendham Society. 1874; 3:386.
8. Biesiadeki, A. Anatomischen Tuberosum multiplex: untersuchungen aus der Pathologisch Lymphangioma Institute in Krakau. Vienna: Wilhelm Braumuller 1972; 2.
9. Van der Putte SC. Anogenital “sweat” glands. Histology and pathology of a gland that may mimic mammary glands. Am J Dermatopathol 1991; 13:557-67.
10. Thomas J, Majmudar B, Gorelkin k. Syringoma localized to the vulva. Arch Dermatol 1979; 115:95-6.
11. Huang YH, Chuang YH, Kuo T, Yang LC, Hong HS. Vulvar syringoma: a clinicopathologic and immunohistologic study of 18 patients and results of treatment J Am Acad Dermatol 2003; 48:735-9.
12. Young AW, Herman EW, Tovell HM. Syringoma of the vulva: incidence, diagnosis. and cause of pruritus. Obstet. Gynecol. 1980; 55:515-8.
13. Carter J, Elliot P. Syringoma: an unusual cause of pruritus vulvae. Aust N Z J Obstet Gynaecol 1990; 30:382-3.
14. Wallace ML, Smoller BR. Progesterone receptor positivity supports hormonal control of syringomas.
J Cutan Pathol 1995; 22:442-5.
15. Goltz RW. Syringoma (syringocystadenoma). Harper and Row; 1976, 22-24.
16. Turan, C, Ugur M, Kutluay L, Kukner S, Dabakoglu T, Aydogdu T, et. Vulvar syringoma exacerbated during pregnancy. Eur J Obstet Gynecol Reprod Biol 1996; 64:141-2.
17. Yorganci A, Kale A, Dunder I, Ensar A, Sertcelik A. Vulvar syringoma showing progesterone receptor positivity. BJOG 2000; 107:292-4.
18. Ghatt HJ, Proia AD, Tsoy EA. Malignant syringoma of the eyelid. Opthalmology. 1984; 91:987-90.
19. Perez-Bustillo A, Ruiz-Gonzalez I, Delgado S, Alonso T, Ingelmo J. Vulvar syringoma: a rare cause of vulvar pruritus. Actas Dermosifiliogr 2008; 99:580-1.
20. Isaacson D, Turner ML. Localized vulvar syringomas. J Am Acad Dermatol 1979; 1:352-7.
21. Pincus SH, McKay M. Disorders of the female genitalia. Dermatology in General Medicine. New York: McGraw-Hill 1993, 1463-81.
22. Brown SM, Freeman RG. Syringoma limited to the vulva. Arch. Dermatol 1971; 104:331.
23. Belardi MG, Maglione MA, Vighi S, Di Paola GR. Syringoma of the vulva: a case report. J Reprod Med 1994; 39:957-9.
24. Di Lemia V, Bisighini G. Localized vulvar syringomas. Pediatr Dermatol 1996; 13:80-1.
| Files | ||
| Issue | Vol 15, No 1 (March 2021) | |
| Section | Case Reports | |
| DOI | https://doi.org/10.18502/jfrh.v15i1.6080 | |
| Keywords | ||
| Vulvar Neoplasms Syringoma Vulvar Diseases | ||
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How to Cite
1.
Algeri P, Rodella R, Manfredini C, Algeri M. An Unusual Case of Genital Lesion: A Vulvar Syringoma. J Family Reprod Health. 2021;15(1):70-73.
