Small Cell Neuroendocrine Cervical Carcinoma: A Case Report
Objective: Small cell neuroendocrine cervical carcinoma is a neuroendocrine tumor with the great aggravation that comprises 0.5 to 3 percent of cervical tumors and progresses rapidly with early lymphogenous and hematogenous metastases.
Case report: We reported a 40 years old woman with cervical cancer in stage IB2 that had radical hysterectomy with mistaken diagnosis of squamous cervical cancer. The disease has progressed after 50 days of surgery with a 6 cm tumor in vaginal cuff; review of pathology demonstrated small cell neuroendocrine cervical carcinoma. Conclusion: Recognition of this separate histopathological entity with IHC analysis is important. Chemoradiotherapy and multimodality therapeutic approaches could improve the survival rates.
2. Delaloge S, Pautier P, Kerbrat P, Castaigne D, Haie-Meder C, Duvillard P, et al. Neuroendocrine small cell carcinoma of the uterine cervix: what disease? What treatment? Report of ten cases and a review of the literature. Clin Onc 2000; 12: 357-62.
3. Zivanovic O, Leitao Jr M M, Park K J, Zhao H, Diaz J P, Konner J, et al. Small cell neuroendocrine carcinoma of the cervix: Analysis of outcome, recurrence pattern and the impact of platinum-based combination chemotherapy. Gynecol Oncol 2009; 112: 590–93.
4. Yasuoka T, Hashimoto H, Hamada K, Fujioka T, Nawa A. Atypical carcinoid of the uterine cervix with aggressive clinical behavior: A case report. Gynecol Oncol Case Rep 2013; 7: 4-6.
5. Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis
B, Kern P et al. Neuroendocrine carcinoma of the cervix: a systematic review of the literature. BMC cancer 2018; 18: 530.
6. Gadducci A, Carinelli S, Aletti G. Neuroendocrine tumors of the uterine cervix: a therapeutic challenge for gynecologic oncologists. Gynecol Oncol 2017; 144: 637–46.
7. Kim JY, Hong SM, Ro JY. Recent updates on grading and classification of neuroendocrine tumors. Ann Diagn Pathol 2017; 29: 11–6.
8. Guadagno E, De RG, de Del Basso Caro M. Neuroendocrine tumors in rare sites: differences in nomenclature and diagnostics-a rare and ubiquitous histotype. J Clin Pathol 2016; 69: 563–74.
9. Burzawa J, Gonzales N, Frumovitz M. Challenges in the diagnosis and management of cervical neuroendocrine carcinoma. Expert Rev Anticancer Ther 2015; 15: 805-10.
10. Lin LM, Lin Q, Liu J, Chu KX, Huang YX, Zhang ZK et al. Prognostic factors and treatment comparison in small cell neuroendocrine carcinoma of the uterine cervix based on population analyses. Cancer Med 2020; 9: 6524-32
11. Kasamatsu T, Sasajima Y, Onda T, Sawada M, Kato T, Tanikawa M: Surgical treatment for neuroendocrine carcinoma of the uterine cervix. Int J Gynaecol Obstet 2007; 99: 225-8.
12. Wang KL, Yang YC, Wang TY, Chen JR, Chen TC, Chen HS et al. Neuroendocrine carcinoma of the uterine cervix: a clinicopathologic retrospective study of 31 cases with prognostic implications. J Chemother 2006; 18: 209-16.
13. Kuji S, Hirashima Y, Nakayama H, Nishio S, Otsuki T, Nagamitsu Y. et al. Diagnosis, clinicopathologic features, treatment, and prognosis of small cell carcinoma of the uterine cervix: Gynecol Oncol 2013; 129: 522-7.
|Issue||Vol 14, No 4 (December 2020)|
|Small Cell Neuroendocrine Tumor Cervical Carcinoma Chemoradiotherapy Chemotherapy|
|Rights and permissions|
|This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.|