A Study of 13315 Papanicolau Smear Diagnoses in Shohada Hospital
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Abstract
Objective: This study aimed to review Papanicolaou (Pap) smears in patients of Shohada hospital in Tehran.
Materials and methods: A cross-sectional descriptive study was carried out and a database search of all Pap smear reports from 1995 to 2005 at cytopathology department was reviewed. The abnormal Pap smear reports based on the Bethesda System were assessed.
Results: A total of 13315 Pap smear reports were reviewed from patients aging 20 to 79 years old. Totally 6065 (45.55%) cases had diagnosis of ‘negative', 293(2.21%) smears were labeled as ‘inadequate', and 6799 (51.06%) reports had ‘Benign cellular changes'. There were 158(1.18%) abnormal Pap smears consisting of 84 (53.18%) SIL with undetermined grade (ASC-US), 28(17.73%) low grade SIL (LSIL), 17(10.75%) high grade SIL (HSIL), 27(17.08%) carcinoma and 2(1.26%) atypical glandular cells of undetermined significance (AGUS). Overall incidence of the cervical cancer among these samples was 0.2%. Benign cellular changes numbered 6799(51.06%), of which 5365 (78.9%) smears demonstrated infectious processes.
Conclusion: The number of abnormal pap smears in this study is less than western countries, but is comparable with Middle East and Islamic regions. More prospective studies are recommended.
Ferlay J, Bray F, Pisani P, Parkin DM, Globocan . Cancer incidence, mortality and prevalence worldwide, database on CD-ROM, IARC Cancer Base Press 2004 ; 5: 2.
Stewart BW, Kleihues P, eds. World cancer report. IARC Press. Lyon 2003.
Lawson HW, Henson R, Bobo JK, Kaeser MK. Implementing recommendations for the early detection of breast and cervical cancer among low-income women. MMWR Recomm Rep 2000; 49(RR-2): 37–55.
Anderson GH, Boyes DA, Benedet JL, Le-Riche JC, Matisic JP, Suen KC, et al. Organisation and results of the cervical cytology screening programme in British Columbia, 1955-85. BM J 1988; 296(6627):975-978.
McCrory DC. Evaluation of cervical cytology. Evidence report/technology assessment no.5. Rockville, Maryland, Agency for Health Care Policy and Research, AHCPR publication 1999;99:10.
Mosavi-Jarrahi A, Mohagheghi MA, Zeraatti H, Mortazavi H. Cancer registration in Iran. Asian Pac J Cancer Prev 2001; 2:25–9.
Rojsangruang S. Prevalence of Abnormal Cervical Cytology based on the Bethesda System at Phetchabun Hospital. Journal of Health Science 2006; 15(1):67-74.
Williams ML, Rimm DL, Pedigo MA, Frable WJ. Atypical squamous cells of undetermined significance: correlative histologic and follow-up studies from an academic medical center. Diagn Cytopathol 1997; 16(1):1–7.
Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer statistics, 2000. CA: a cancer journal for clinicians 2000; 50(1):7–33.
Johannesson G, Giersson G, Day N. The effect of mass screening in Iceland, 1965–74, on the incidence and mortality of cervical carcinoma. International journal of cancer 1978, 21(4):418–25.
Hakama M. Effect of organized screening on the risk of cervical cancer in the Nordic countries. In: Miller AB, eds. Cancer screening: UICC project on evaluation of screening for cancer. Cambridge, United Kingdom: International Union Against Cancer, 1999:153–62.
Mount SL, Papillo JL. A study of 10,296 pediatric and adolescent Papanicolau smear diagnosis in northern New England. Pediatrics 1999 103(3):539–45.
Abdullah LS. Pattern of abnormal Pap smears in developing countries: a report from a large referral hospital in Saudi Arabia using the revised 2001 Bethesda System. Ann Saudi Med 2007;27(4):268-72.
Wright TC, Cox JT, Massad LS, Twiggs LB, Wilkinson EJ. 2001 consensus guidelines for the management of women with cervical cytopathological abnormalities. J Low Genit Tract Dis 2002; 6:127–43.
Soutter WP, Fletcher A. Invasive cancer of the cervix in women with mild dyskaryosis followed up cytologically. BMJ 1994; 308(6941):1421–1423.
Gustafsson L, Sparén P, Gustafsson M, Pettersson B, Wilander E, Bergström R, et al. Low efficiency of cytologic screening for cancer in situ of the cervix in older women. Int J Cancer 1995; 63(9):804–9.
Sadeghi SB, Hsieh EW, Gunn SW. Prevalence of cervical intraepithelial neoplasia in sexually active teenagers and young adults. Am J Obstet Gynecol 1984; 148(6):726–729
National Cancer Institute Bethesda System 2001. Web site available at: http://www.bethesda , 2001. cancer.gov, last modification in July 2002.
Altaf F. Pattern of cervical smear cytology in the western region of Saudi Arabia. Annals of Saudi Medicine 2001; 21: 94-96.
Mood NI, Eftekhar Z, Haratian A, Saeedi L, Rahimi-Moghaddam P, Yarandi F. A cytohistologic study of atypical glandular cells detected in cervical smears during cervical screening tests in Iran. Int J Gynecol Cancer 2006 ;16(1):257-61.
Sadjadi A, Malekzadeh R, Derakhshan MH, Sepehr A, Nourae M, Sotudeh M,et al. Cancer occurrence inArdabil: results of a population based cancer registry from Iran. Int J Cancer 2003; 107: 113–118 .
Sankaranarayanana R, Gaffikin L, Jacob M, Sellors J, Robles S . A critical assessment of screening methods for cervical neoplasia. International Journal of Gynecology and Obstetrics 2005; 89(2), S4-S12.
Kuhn L, Denny L, Pollack A, Richart RM, Wright TC. Human papilloma virus DNA testing for cervical cancer in low resources settings. J Natl Cancer Inst 2000; 17( 92): 818-825.
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| Issue | Vol 1, No 2 (December 2007) | |
| Section | Original Articles | |
| Keywords | ||
| Abnormal cervical cytology Bethesda System | ||
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