Effect of Flushing the Endometrial Cavity With Follicular Fluid on Implantation Rates in Sub-Fertile Women Undergoing Invitro Fertilization: A Randomized Clinical trial

  • Kobra Hamdi Department of Gynecology and Obstetrics, Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammad Nouri Department of Gynecology and Obstetrics, Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • sara Farzaneh Department of Gynecology and Obstetrics, Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammad Mirza-Aghazadeh-Attari Department of Community and Family Medicine, Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran http://orcid.org/0000-0001-7927-6912
  • Mohammad Naghavi-Behzad 1 Department of Community and Family Medicine, Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. 2 Department of Nuclear Medicine, University of Southern Denmark, Odense, Denmark
  • Sahar Mohammadi Department of Emergency Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Keywords: Endometrial Cavity, Follicular Fluid, Invitro Fertilization, Implantation

Abstract

Objective: To examine the effectiveness of intrauterine injection of follicular fluid in in vitro fertilization (IVF).Materials and methods: A parallel randomized control clinical study was conducted on 110 patients attending Al–Zahra Educational-Medical Center of Tabriz University of Medical Sciences. Female candidates for IVF were categorized into intervention (n = 55) and control (n = 55) groups using Randlast software (version 1.2). Following an identical protocol of gonadotropin-releasing hormone (Gnrh) antagonist stimulating ovulation, in the intervention group a total of 2mL of follicular fluid was injected as intrauterine after the accomplishment of follicular puncture. Embryo transfer was carried out after 2-3 days. The rates of implantation, as well as chemical and clinical pregnancy were compared between the two groups.Results: There were no significant differences in chemically proven pregnancy (19 in intervention group (34.5%) vs. 23 (41.8%) in control group p = 0.43), or in clinical pregnancy (30.9% vs. 38.2%, respectively p = 0.42), and in implantation rates (11.52 ± 2.57 % (range, 0-66.7) vs 18.79 ± 3.72 % (range, 0-100), respectively).Conclusion: Injection of follicular fluid into the uterine cavity in candidates for IVF neither improves nor adversely affects the outcome of the therapy.

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Published
2019-02-05
How to Cite
1.
Hamdi K, Nouri M, Farzaneh sara, Mirza-Aghazadeh-Attari M, Naghavi-Behzad M, Mohammadi S. Effect of Flushing the Endometrial Cavity With Follicular Fluid on Implantation Rates in Sub-Fertile Women Undergoing Invitro Fertilization: A Randomized Clinical trial. J Fam Reprod Health. 12(4):184-190.
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Original Articles