Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 12 4 2018 12 27 184 190 EN Kobra Hamdi Department of Gynecology and Obstetrics, Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Mohammad Nouri Department of Gynecology and Obstetrics, Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Sara Farzaneh Department of Gynecology and Obstetrics, Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Mohammad Mirza-Aghazadeh-Attari Department of Community and Family Medicine, Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Mohammad Naghavi-Behzad Department of Community and Family Medicine, Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. AND Department of Nuclear Medicine, University of Southern Denmark, Odense, Denmark Sahar Mohammadi Department of Emergency Medicine, Zanjan University of Medical Sciences, Zanjan, Iran 2018 03 09 2019 01 29 Objective: To examine the effectiveness of intrauterine injection of follicular fluid in in vitro fertilization (IVF). Materials and methods: A parallel randomized control clinical study was conducted on 110 patients attending Al–Zahra Educational-Medical Center of Tabriz University of Medical Sciences. Female candidates for IVF were categorized into intervention (n = 55) and control (n = 55) groups using Randlast software (version 1.2). Following an identical protocol of gonadotropin-releasing hormone (Gnrh) antagonist stimulating ovulation, in the intervention group a total of 2mL of follicular fluid was injected as intrauterine after the accomplishment of follicular puncture. Embryo transfer was carried out after 2-3 days. The rates of implantation, as well as chemical and clinical pregnancy were compared between the two groups. Results: There were no significant differences in chemically proven pregnancy (19 in intervention group (34.5%) vs. 23 (41.8%) in control group p = 0.43), or in clinical pregnancy (30.9% vs. 38.2%, respectively p = 0.42), and in implantation rates (11.52 ± 2.57 % (range, 0-66.7) vs 18.79 ± 3.72 % (range, 0-100), respectively). Conclusion: Injection of follicular fluid into the uterine cavity in candidates for IVF neither improves nor adversely affects the outcome of the therapy. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/833 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/833/467