Journal of Family and Reproductive Health 2011. 5(3):73-78.

A Randomized Controlled Clinical Trial of Olive Oil Added to Human Breast Milk for Weight Gaining in Very Low Birth Weight Infants
Elaheh Amini, Mamak Shariat, Fatemeh Nayeri, Firoozeh Nili, Bita Ebrahim, Hosein Dalili


Objective: Evaluating the effect of vegetable oil, as a supplement to breast milk in increase the weight gaining of VLBW neonates.
Materials and methods: In this single blind; Randomized clinical trials , in NICU of Vali-asr Hospital, Tehran University of Medical Sciences, 2005-2006;A total of 48 VLBW neonates referred & admitted to NICU, who did not have any major GI (especially NEC), respiratory or cardiac diseases; participated randomly in two groups: intervention & control.Vegetable oil was added to the milk of 25 neonates (0.5 cc per 30cc of milk) and the other 25neonates with similar conditions that were selected as a control group, did not get any type of supplementary nutrition. Daily feeding volume in both groups was 150-200 cc for each kilogram of body weight.
Results: Weight gaining in interventional groups was considerably more than control group. (p<0.04).There were also significant statistical differences in hospitalization period between the two groups, 28.9 days in interventional and 20.33 days in control group, (p<0.03).However, no significant side effects were observed.
Conclusions: There is no report regarding contraindication linking the use of vegetable oil intended for appropriate weight gaining or reducing hospitalization period to neonatal chronic diseases.


Vegetable Oil; VLBW infant; Neonatal weight gain

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B.J.Stoll. Overview of mortality & Morbidity. R. M. Kliegman, R. E. Behrman, H.l B. Jenson, B.F. Stanton. Nelson Textbook of Pediatrics, 18th. Edition,2007,Saunders-Elsevier Co.,pp:671-675

Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant, 2-Volume Set (Hardcover)-MOSBY-2036: 2005

Fanaroff, R. J. Martin, R. J. Rodriguez. Identification & management of problems in the high –risk neonate .In: R.K. Creasy, R.Resink, J.D.Iams. Maternal Fetal Medicine, Principles & Practice. Fifth Edition, SAUNDERS Co., 2004; pp: 1263-1302.

Kery, S. Murray, R. In: "Clinical nutrition, Enteral and tube feeding”. (Rombea. Culdwell). 2th ed .w. b saunders company. P 131 – 132

Vaidya UV, Hegde VM, Bhave SA, Pandit AN. "Vegetable oil fortified feeds in the nutrition of very low birth weight babies” Indian Pediatr 1992; 29:1519-27.

Makrides M, Gibson RA, McPhee AJ, Collins CT,Davis PG, Doyle LW, et al. Neurodevelopment outcomes of preterm infants fed high – dose docosahexaenoic acid: a RCT. JAMA 2009, 301 : 175 -82.

Innis SM. Dietary omega 3 fatty acids and the developing brain. Brain Res 2008: 1237: 35-43.

Nova K EM, Dyer RA, Innis SM. High dietary omega -6 fatty acids contribute to reduced docosahexaenoic acid inhibits secondary neuritis growth. Brain Res 2008; 1237: 136-4.


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