Effect of Falcaria Vulgaris on Milk Production Parameters in Female Rats’ Mammary Glands
Abstract
Objective: Falcaria Vulgaris (F.Vulgaris) is a multipurpose herb in traditional medicine, containing essential amino acids, vitamins and numerous nutrients. The aim of this study was to determine the effects of F.Vulgaris on the on the milk production parameters in rats.
Materials and methods: In this experimental study, 32 wistar female rats were equally divided into 4 groups; group1, control group and group2-4, experimental groups by various doses of F.Vulgaris (20, 50, 100 mg/kg) injected interaperitoneally once a day for 21 consecutive days. The milk production parameters including, diameter and number of alveoli, prolactin hormone level and receptor prolactin (PRLR) gene expression in mammillary gland tissue were measured and compared.
Results: The results indicated that F.Vulgaris significantly increased diameter and number of alveoli, prolactin hormone level and PRLR gene expression compared to control group (p < 0.05).
Conclusion: F.Vulgaris extract has positive effects on the milk production parameters in mammary glands.
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2. Tombs E, Sridaromont K, Moore A. Continuum of care for mother and child during breastfeeding. Nursing made Incredibly Easy 2018; 16:16-20.
3. Jalili C, Salahshoor MR, Yousefi D, Khazaei M, Shabanizadeh Darehdori A, Mokhtari T. Morphometric and Hormonal Study of the Effect of Utrica diocia Extract on Mammary Glands in Rats. Int. J. Morphol 2015; 33:983-7.
4. Rosenbaum ME, Lenoch S, Ferguson KJ. Outcomes of a teaching scholars program to promote leadership in faculty development. Teach Learn Med 2005; 17:247-52.
5. Walker AR, Adam FI. Breast-feeding in sub-Saharan Africa: outlook for 2000. Public Health Nutr 2000;3:285-92.
6. Velle-Forbord V, Underdal MO, Vanky E. Breastfeeding and Future Maternal Health—No Causal Evidence. JAMA Intern Med 2018; 178:870-1.
7. Akinloye AK, Oke BO. Sex Hormonal Pattern of the Female African Giant Rat (Cricetomys gambianus, Waterhouse) at Different Stages of the Oestrous Cycle. Nigerian Veterinary Journal 2012; 33:586-91.
8. Knoppert DC, Page A, Warren J, Seabrook JA, Carr M, Angelini M, et al. The Effect of Two Different domperidone Doses on Maternal Milk Production. J Hum Lact 2013; 29:38-44.
9. Rafiey Z, Jalili F, Sohrabi M, Salahshoor MR, Jalili C. Effects of hydro-alcoholic extract of falcaria vulgaris on pancreas tissue in streptozotocin-induced diabetic rats. Iranian J Endocrin Metab 2017; 19:91-8.
10. Salahshoor MR, Jalili P, Roshankhah Sh, Makalani F, Jalili C. The effect of F. vulgaris extract on Streptozotocin induced diabetic rats. Pharmacophore 2017; 8(6s): e-1173298
11. Khazaei M, Salehi H. Protective effect of Falcaria vulgaris extract on ethanol induced gastric ulcer in rat. Iranian Journal of pharmacology and Therapeutics 2006;5:43-6.
12. Hamideh J, Khosro P, Javad ND. Callus induction and plant regeneration from leaf explants of Falcaria vulgaris an important medicinal plant. Journal of Medicinal Plants Research 2012; 6:3407-14.
13. Shafaghat A. Free radical scavenging and antibacterial activities, and GC/MS analysis of essential oils from different parts of Falcaria vulgaris from two regions. Nat Prod Commun 2010; 5:981-4.
14. Choobkar N, Kakoolaki S, Mohammadi F. The biological effects of herbal medicine, Falcaria vulgaris: An article review. Iranian Journal of Aquatic Animal Health 2017; 3:74-83.
15. Salahshoor MR, Roshankhah S, Hosseni P, Jalili C. Genistein Improves Liver Damage in Male Mice Exposed to MorphineGenistein Improves Liver Damage in Male Mice Exposed to Morphine. Chin Med J (Engl) 2018; 131:1598-604.
16. Nikbakht M, Salahshoor MR, Mardani M, Rabbani M, Hashemibeni B, Gharagozloo M, et al. The apoptotic effects of sirtuin1 inhibitor on MCF-7 and MRC-5 cell lines. Res Pharm Sci 2013; 8:79-89.
17. Nagano M, Kelly PA. Tissue distribution and regulation of rat prolactin receptor gene expression. Quantitative analysis by polymerase chain reaction. J Biol Chem 1994; 269:13337-45.
18. Dill R, Walker AM. Role of prolactin in promotion of immune cell migration into the mammary gland. J Mammary Gland Biol Neoplasia 2017; 22:13-26.
19. Wirawati CU, Sudarwanto MB, Lukman DW, Wientarsih I. Local Plants as Feed Supplementation to Improve Ruminant Milk Production and Quality. WARTAZOA 2018; 27:145-57.
20. AL-Shemary NN, Mousa SA, Muslim ZZ. Histological and Hormonal Study about the Effect of Aqueous Extract of Ocimum gratissmum on Female Reproductive System in Albino Mice. Journal of Pharmaceutical Sciences and Research 2018;10:765-7.
21. Daniel EE, Hamman WO, Olorunshola KV, Malgwi IS. The study of effect of aqueous Cucurbita pepo linn seed extract on serum prolactin level of lactating female albinorats. Scientific Journal of Medical Science 2013; 2:6-11.
22. BolzÁn AD, Bianchi MS, Cónsole GM, Goya RG. Relationship between pituitary hormones, antioxidant enzymes, and histopathological changes in the mammary gland of senescent rats. Exp Gerontol 1997; 32:297-304.
23. Oakes SR, Rogers RL, Naylor MJ, Ormandy CJ. Prolactin regulation of mammary gland development.J Mammary Gland Biol Neoplasia 2008;13:13-28.
24. Papiez MA. Influence of naringenin on the activity of enzymes participating in steroidogenesis in male rats. Rocz Akad Med Bialymst 2004; 49 Suppl 1:120-2.
25. Panjeshahin MR, Dehghani F, Talaei-Khozani T, Panahi Z. The effects of hydroalcholic extract of Actinidia chinesis sperm count and motility and on the blood levels of estradiol and testosterone in male rats. Arch Iran Med 2005;8:211-16.
26. Adler S, Waterman ML, He X, Rosenfeld MG. Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain. Cell 1988; 52:685-95.
27. Lan H, Hong P, Li R, Suo L, Anshan S, Li S, Zheng X. Internal image anti-idiotypic antibody: a new strategy for the development a new category of prolactin receptor (PRLR) antagonist. Mol Immunol 2017; 87:86-93.
28. Gass S, Harris J, Ormandy C, Brisken C. Using gene expression arrays to elucidate transcriptional profiles underlying prolactin function. J Mammary Gland Biol Neoplasia 2003; 8:269-85.
29. Zhou G, Tang L, Wang T, Zhou X, Kou Z, Wu J, et al. Phytochemistry and pharmacological activities of Vaccaria hispanica (Miller) Rauschert: a review. Phytochem Rev 2016; 15:813-27.
2. Tombs E, Sridaromont K, Moore A. Continuum of care for mother and child during breastfeeding. Nursing made Incredibly Easy 2018; 16:16-20.
3. Jalili C, Salahshoor MR, Yousefi D, Khazaei M, Shabanizadeh Darehdori A, Mokhtari T. Morphometric and Hormonal Study of the Effect of Utrica diocia Extract on Mammary Glands in Rats. Int. J. Morphol 2015; 33:983-7.
4. Rosenbaum ME, Lenoch S, Ferguson KJ. Outcomes of a teaching scholars program to promote leadership in faculty development. Teach Learn Med 2005; 17:247-52.
5. Walker AR, Adam FI. Breast-feeding in sub-Saharan Africa: outlook for 2000. Public Health Nutr 2000;3:285-92.
6. Velle-Forbord V, Underdal MO, Vanky E. Breastfeeding and Future Maternal Health—No Causal Evidence. JAMA Intern Med 2018; 178:870-1.
7. Akinloye AK, Oke BO. Sex Hormonal Pattern of the Female African Giant Rat (Cricetomys gambianus, Waterhouse) at Different Stages of the Oestrous Cycle. Nigerian Veterinary Journal 2012; 33:586-91.
8. Knoppert DC, Page A, Warren J, Seabrook JA, Carr M, Angelini M, et al. The Effect of Two Different domperidone Doses on Maternal Milk Production. J Hum Lact 2013; 29:38-44.
9. Rafiey Z, Jalili F, Sohrabi M, Salahshoor MR, Jalili C. Effects of hydro-alcoholic extract of falcaria vulgaris on pancreas tissue in streptozotocin-induced diabetic rats. Iranian J Endocrin Metab 2017; 19:91-8.
10. Salahshoor MR, Jalili P, Roshankhah Sh, Makalani F, Jalili C. The effect of F. vulgaris extract on Streptozotocin induced diabetic rats. Pharmacophore 2017; 8(6s): e-1173298
11. Khazaei M, Salehi H. Protective effect of Falcaria vulgaris extract on ethanol induced gastric ulcer in rat. Iranian Journal of pharmacology and Therapeutics 2006;5:43-6.
12. Hamideh J, Khosro P, Javad ND. Callus induction and plant regeneration from leaf explants of Falcaria vulgaris an important medicinal plant. Journal of Medicinal Plants Research 2012; 6:3407-14.
13. Shafaghat A. Free radical scavenging and antibacterial activities, and GC/MS analysis of essential oils from different parts of Falcaria vulgaris from two regions. Nat Prod Commun 2010; 5:981-4.
14. Choobkar N, Kakoolaki S, Mohammadi F. The biological effects of herbal medicine, Falcaria vulgaris: An article review. Iranian Journal of Aquatic Animal Health 2017; 3:74-83.
15. Salahshoor MR, Roshankhah S, Hosseni P, Jalili C. Genistein Improves Liver Damage in Male Mice Exposed to MorphineGenistein Improves Liver Damage in Male Mice Exposed to Morphine. Chin Med J (Engl) 2018; 131:1598-604.
16. Nikbakht M, Salahshoor MR, Mardani M, Rabbani M, Hashemibeni B, Gharagozloo M, et al. The apoptotic effects of sirtuin1 inhibitor on MCF-7 and MRC-5 cell lines. Res Pharm Sci 2013; 8:79-89.
17. Nagano M, Kelly PA. Tissue distribution and regulation of rat prolactin receptor gene expression. Quantitative analysis by polymerase chain reaction. J Biol Chem 1994; 269:13337-45.
18. Dill R, Walker AM. Role of prolactin in promotion of immune cell migration into the mammary gland. J Mammary Gland Biol Neoplasia 2017; 22:13-26.
19. Wirawati CU, Sudarwanto MB, Lukman DW, Wientarsih I. Local Plants as Feed Supplementation to Improve Ruminant Milk Production and Quality. WARTAZOA 2018; 27:145-57.
20. AL-Shemary NN, Mousa SA, Muslim ZZ. Histological and Hormonal Study about the Effect of Aqueous Extract of Ocimum gratissmum on Female Reproductive System in Albino Mice. Journal of Pharmaceutical Sciences and Research 2018;10:765-7.
21. Daniel EE, Hamman WO, Olorunshola KV, Malgwi IS. The study of effect of aqueous Cucurbita pepo linn seed extract on serum prolactin level of lactating female albinorats. Scientific Journal of Medical Science 2013; 2:6-11.
22. BolzÁn AD, Bianchi MS, Cónsole GM, Goya RG. Relationship between pituitary hormones, antioxidant enzymes, and histopathological changes in the mammary gland of senescent rats. Exp Gerontol 1997; 32:297-304.
23. Oakes SR, Rogers RL, Naylor MJ, Ormandy CJ. Prolactin regulation of mammary gland development.J Mammary Gland Biol Neoplasia 2008;13:13-28.
24. Papiez MA. Influence of naringenin on the activity of enzymes participating in steroidogenesis in male rats. Rocz Akad Med Bialymst 2004; 49 Suppl 1:120-2.
25. Panjeshahin MR, Dehghani F, Talaei-Khozani T, Panahi Z. The effects of hydroalcholic extract of Actinidia chinesis sperm count and motility and on the blood levels of estradiol and testosterone in male rats. Arch Iran Med 2005;8:211-16.
26. Adler S, Waterman ML, He X, Rosenfeld MG. Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain. Cell 1988; 52:685-95.
27. Lan H, Hong P, Li R, Suo L, Anshan S, Li S, Zheng X. Internal image anti-idiotypic antibody: a new strategy for the development a new category of prolactin receptor (PRLR) antagonist. Mol Immunol 2017; 87:86-93.
28. Gass S, Harris J, Ormandy C, Brisken C. Using gene expression arrays to elucidate transcriptional profiles underlying prolactin function. J Mammary Gland Biol Neoplasia 2003; 8:269-85.
29. Zhou G, Tang L, Wang T, Zhou X, Kou Z, Wu J, et al. Phytochemistry and pharmacological activities of Vaccaria hispanica (Miller) Rauschert: a review. Phytochem Rev 2016; 15:813-27.
| Files | ||
| Issue | Vol 12, No 4 (December 2018) | |
| Section | Original Articles | |
| Keywords | ||
| Milk Mammary Glands Animal | ||
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How to Cite
1.
Salahshoor MR, Mohammadi MM, Roshankhah S, Jalili C. Effect of Falcaria Vulgaris on Milk Production Parameters in Female Rats’ Mammary Glands. J Family Reprod Health. 2018;12(4):177-183.
