The Role of Serum Uric Acid in Preeclampsia
Objective: The goal of this study was to assess the utility of serum uric acid in preeclampsia diagnosis and its correlation with some maternal and fetal outcomes.
Materials and methods: A case-control study was performed on 26 term pregnant women with preeclampsia and 52 normal pregnant women. Serum uric acid, platelet count, hematocrit, gestational age, and birth weight of all patients were measured. Data distribution was assessed with the one sample Kolmogorov-Smirnov test. Mann-Whitney U test was used to assess differences between groups. Correlations between plasma uric acid and other parameters were evaluated with the Spearman’s Rho or Pearson correlation test, where appropriated. Receiver-operating characteristics (ROC) curves were used to assess the ability of plasma uric acid to distinguish the preeclampsia from normal subjects. Significance was set at P< 0.05.
Results: The mean level of plasma uric acid was 5.8 (+2) mg/dl in cases and 4.9 mg/dl in controls (P=0.04). ROC curve analysis demonstrates the absence of obvious cut off point for plasma uric acid to distinguish preeclampsia. Sensitivity and specificity for uric acid level of 5.5 mg/dl were 61.5% and 78.8%, respectively. There was no significant linear correlation between the plasma uric acid level and other measured parameters in each group.
Conclusion: On the basis of our data, the clinical utility of measuring serum uric acid levels in diagnosing preeclampsia is limited.
Kaypour F, Masomi Rad H, Ranjbar Novin N. The predictive value of serum uric acid, roll-over test, and body mass index in preeclampsia. Int J Gynecol Obstet 2006; 92: 133-4.
Thangaratinam S, Ismail KM, Sharp S, Coomarasamy A, Khan KS. Tests in prediction of pre-eclampsia severity review group. Accuracy of serum uric acid in predicting complications of pre-eclampsia: a systematic review. BJOG 2006; 113: 369-78.
Cnossen JS, Ruyter-Hanhijarvi HD, Van Der Post JA, Mol BW, Khan KS, Ter Riet G. Accuracy of serum uric acid determination in predicting pre-eclampsia. Acta Obstetricia et Gynecologica 2006; 85; 519-25.
Weerasekera DS, Peiris H. The significance of serum uric acid, creatinine and urinary microprotein levels in predicting pre-eclampsia. J Obstet Gynecol 2003; 23: 17-9.
Slemmons J, Bogert L. The uric acid content of maternal and fetal blood. J Biol Chem 1917; 32 : 63-9.
Bainbridge SA, Roberts JM. Uric acid as a pathogenic factor in preeclampsia. Placenta 2008; 29: S67-72.
Lim KH, Friedman SA, Ecker JL, Kao L, Kilpatrick SJ. The clinical utility of serum uric acid measurements in hypertensive diseases of pregnancy. Am J Obstet Gynecol 1998; 178: 1067- 71 .
Roberts JM, Bodnar LM, Lain KY, Hubel CA, Markovic N, Ness RB,et al. Uric acid is as important as proteinuria in identifying fetal risk in women with gestational hypertention. Hypertension 2005; 46: 1250-1.
Salako BL, Odukogbe AT, Olayemi O, Adedapo KS, Aimakhu CO, Alu FE, et al. Serum albumin, creatinine, uric acid and hypertensive disorders of pregnancy. East African Me J 2003; 80: 424-8.
National high blood pressure education program working group. Report on high blood pressure in pregnancy. Am J Obstet Gynecol 1990; 163: 1689-712.
Acien P, Lloret G, Lloret M. Perinatal morbidity and mortality in pregnancy hypertensive disorders: prognostic value of the clinical and laboratory findings. Int J Gynecol Obstet 1990; 32 : 229-35.
Paternoster DM, Stella A, Mussap M, Plebani M, Gambaro G, Grella PV. Predictive markers of pre-eclampsia in hypertensive disorders of pregnancy. Int J Gynaecol Obstet 1999; 66: 237-43.
|Issue||Vol 2, No 3 (September 2008)|
|Uric acid Preeclampsia Pregnancy Diagnostic test|
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