Case Reports

Occurrence of Budd-Chiari Syndrome as Adverse Effect of Long Term DMPA Injections: A Case Report and Review the Literatures

Abstract

Budd-Chiari syndrome (BCS) refers to thrombosis of hepatic veins as well as intrahepatic or suprahepatic inferior vena cava. We present for the first time a case of possible occurrence of Budd- Chiari syndrome with the history of depot medroxy progesterone acetate (DMPA) injections in a 33-yearold Iranian woman. An underlying disorder can be identified in most of patients with BCS. Many of these disorders are characterized by a hypercoagulable state, but it may occur due to other unknown pathophysiologic factors. Also, medical evaluation was performed for inflammatory, immunologic, and thrombotic disorders as well as hepatic imaging. Considering different case reports like this study may help to decrease the percentage of idiopathic cases.

Menon KV, Shah V, Kamath PS. The Budd-Chiari syndrome. N Engl J Med 2004 ; 350:578-85.

Darwish Murad S, Valla DC, de Groen PC, Zeitoun G, Hopmans JA, Haagsma EB, et al. Determinants of survival and the effect of portosystemic shunting in patients with Budd-Chiari syndrome. Hepatology 2004; 39:500-8.

Mahmoud AE, Mendoza A, Meshikhes AN, Olliff S, West R, Neuberger J, Et al. Clinical spectrum, investigations and treatment of Budd-Chiari syndrome. QJM 1996; 89:37- 43.

Darwish Murad S, Plessier A, Hernandez-Guerra M, Fabris F, Eapen CE, Bahr MJ, Et al. (European Network for Vascular Disorders of the Liver). Etiology, management, and outcome of the Budd-Chiari syndrome. Ann Intern Med 2009; 151:167- 75.

Lalonde G, Théoret G, Daloze P, Bettez P, Katz SS. Inferior vena cava stenosis and Budd--Chiari syndrome in a woman taking oral contraceptives. Gastroenterology 1982; 82:1452-6.

Perarnau JM, Bacq Y. Hepatic vascular involvement related to pregnancy, oral contraceptives, and estrogen replacement therapy. Semin Liver Dis 2008; 28:315-27.

Murphy FB, Steinberg HV, Shires GT 3rd, Martin LG, Bernardino ME. The Budd-Chiari syndrome: a review. AJR Am J Roentgenol 1986; 147:9-15.

Gupta S, Blumgart LH, Hodgson HJ. Budd-Chiari syndrome: long-term survival and factors affecting mortality. Q J Med 1986; 60:781-91.

Jayanthi V, Udayakumar N. Budd-Chiari Syndrome. Changing epidemiology and clinical presentation. Minerva Gastroenterol Dietol 2010; 56:71-80.

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IssueVol 6, No 4 (December 2012) QRcode
SectionCase Reports
Keywords
Budd-Chiari Syndrome Progestin Thrombosis of the Hepatic Veins

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How to Cite
1.
Mahdavi A, Hosseini-Jadda S. Occurrence of Budd-Chiari Syndrome as Adverse Effect of Long Term DMPA Injections: A Case Report and Review the Literatures. J Family Reprod Health. 2012;6(4):183-185.