Transvaginal Sonographic Assessment of the Follicular Development and Endometrial Thickness in Spontaneous and Clomiphene Citrate-Induced Cycles
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Abstract
Objective: To assess follicular development and endometrial growth using transvaginal sonography in spontaneous and clomiphene citrate induced (CC) cycles.
Materials and methods: One hundred consecutive couples with unexplained infertility were recruited for this cross sectional study from 2003 to 2005. Patients were monitored for the first cycle with no medication while the laboratory routine test results were being prepared. Clomiphene citrate (150 mg) was administered on days 5 to 9 of cycle in 60 women. The pattern of the follicular development and endometrial growth was evaluated between clomiphene citrate-induced cycles and spontaneous cycles. SPSS software and student t test were used for analyzing the results. P value less than 0.05 was considered for statistical significance.
Results: The patterns of follicular development and endometrial growth were similar in both study cycles.
Conclusion: Clomiphene citrate-induced cycles did not show different follicular and endometrial growth patterns compared with spontaneous cycles, so this must be regarded in treatment decision making.
Dickey RP, Holtkamp DE. Development, pharmacology and clinical experience with clomiphene citrate. Hum Reprod Update 1996;2:483.
Hughes E, Collins J, Vandekerckhove P. Clomiphene citrate for unexplained subfertility in women. Cochrane Database Syst Rev 2000; CD000057.
Teramoto S, Kato O. Minimal ovarian stimulation with clomiphene citrate: a large-scale retrospective study. Reprod Biomed Online 2007;15:134-48.
Kafy S, Tulandi T. New advances in ovulation induction. Curr Opin Obstet Gynecol 2007;19:248-52.
Randall JM, Templeton A. Transvaginal sonographic assessment of follicular and endometrial growth in spontaneous and clomiphene citrate cycles. Fertil Steril 1991; 56:208–12.
Huneeus A, Hess R, Triantafilo Y, Parada M, Alam V. Follicular and endometrial growth profiles in stimulated cycles with clomiphene citrate. Rev Chil Obstet Ginecol 1994;59:463-8.
Cohen BM, Berry L, Roethemeyer V, Smith D. Sonographic assessment of late proliferative phase endometrium during ovulation induction. J Reprod Med 1992;37:685-90.
Nakamura Y, Ono M, Yoshida Y, Sugino N, Ueda K , Kato H. Effects of clomiphene citrate on the endometrial thickness and echogenic pattern of the endometrium. Fertil Steril 1997;67:256–60.
Haritha S, Rajagopalan G. Follicular growth, endometrial thickness, and serum estradiol levels in spontaneous and clomiphene citrate-induced cycles. Int J Gynaecol Obstet 2003;81:287-92.
Sereepapong W, Suwajanakorn S, Triratanachat S, Sampatanukul P, Pruksananonda K, Boonkasemsanti W, et al. Effects of clomiphene citrate on the endometrium of regularly cycling women. Fertil Steril 2000;73:287-91.
Wolman I, Sagi J, Pauzner D, Yovel I, Seidman DS, David MP. Transabdominal ultrasonographic evaluation of endometrial thickness in clomiphene citrate-stimulated cycles in relation to conception. J Clin Ultrasound 1994;22:109-12.
Dickey RP, Olar TT, Taylor SN, Curole DN, Matulich EM. Relationship of endometrial thickness and pattern to fecundity in ovulation induction cycles: effect of clomiphene citrate alone and with human menopausal gonadotropin. Fertil Steril 1993;59:756-60.
Isaacs JD Jr, Wells CS, Williams DB, Odem RR, Gast MJ, Strickler RC. Endometrial thickness is a valid monitoring parameter in cycles of ovulation induction with menotropins alone. Fertil Steril 1996; 65:262-6.
Karlström PO, Bakos O, Bergh T, Lundkvist O. Hormone and ultrasound parameters in ovarian stimulation cycles for direct intraperitoneal insemination. Hum Reprod 1992;7:813-20.
Randall JM, Templeton A. The effects of clomiphene citrate upon ovulation and endocrinology when administered to patients with unexplained infertility. Hum Reprod 1991;6:659-64.
| Files | ||
| Issue | Vol 2, No 1 (March 2008) | |
| Section | Original Articles | |
| Keywords | ||
| Infertility Clomiphene citrate Follicular development Endometrial thickness | ||
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