Lifetime Attributable Risk for Breast Cancer Induced by High-Resolution Computed Tomography During COVID-19 Pandemic
Abstract
Objective: The widespread utilization of high-resolution computed tomography (HRCT) for diagnosing and management of COVID-19 during the pandemic has prompted worries regarding a potential rise in future breast cancer cases. We aimed to estimate the Life Attributable Risk (LAR) of breast cancer in Shiraz, Iran, linked to HRCT use during the COVID-19 pandemic.
Materials and methods: A cross-sectional study was conducted at Namazi Hospital in Shiraz from February 2, 2020, to December 31, 2022.The Imaging Performance Assessment of CT Scanners (ImPACT) patient dosimetry calculator was used to determine organ doses. LAR was computed utilizing the Biological Effects of Ionizing Radiation (BEIR) Committee models.
Results: The sample size was 666, with ages spanning from 15 to 95 years. 25% (168) had HRCT more than once (2 to 8 times). The mean and 95% uncertainty limits (UL) for Total LAR of breast cancer, considering both single and multiple doses of radiation exposure, was 217 (95% UL, 194-244) per 100,000 persons.
Conclusion: According to our research, the risk of potential breast cancer should not be overlooked. It is advised to use the ultra-low-dose protocol over the low-dose in HRCT. Physicians, pulmonologists, and infectious disease specialists are advised to avoid unnecessary and repeated requests for chest HRCT in a short period.
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13. Grant EJ, Brenner A, Sugiyama H, Sakata R, Sadakane A, Utada M, et al. Solid cancer incidence among the life span study of atomic bomb survivors: 1958–2009. Radiation research. 2017;187(5):513-37.
14. De Gonzalez AB, Salotti JA, McHugh K, Little MP, Harbron RW, Lee C, et al. Relationship between paediatric CT scans and subsequent risk of leukaemia and brain tumours: assessment of the impact of underlying conditions. British journal of cancer. 2016;114(4):388-94.
15. de Gonzalez AB, Darby S. Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries. The lancet. 2004;363(9406):345-51.
16. Breast cancer facts. Available: https://www.who.int/news-room/fact-sheets/detail/breast-cancer.
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25. Jamshidi MH, Karami A, Salimi Y, Keshavarz A. Patient effective dose and radiation biological risk in the chest and abdominopelvic computed tomography. Applied Radiation and Isotopes. 2023;193:110628.
26. Lahham A, ALMasri H, Kameel S. Estimation of female radiation doses and breast cancer risk from chest CT examinations. Radiation Protection Dosimetry. 2018;179(4):303-9.
27. Zondervan RL, Hahn PF, Sadow CA, Liu B, Lee SI. Frequent body CT scanning of young adults: indications, outcomes, and risk for radiation-induced cancer. Journal of the American College of Radiology. 2011;8(7):501-7.
2. McFee R. Middle East respiratory syndrome (MERS) coronavirus. Disease-a-Month. 2020;66(9):101053.
3. Bala PC, Eisenreich BR, Yoo SBM, Hayden BY, Park HS, Zimmermann J. Openmonkeystudio: Automated markerless pose estimation in freely moving macaques. BioRxiv. 2020.
4. Wen Z, Chi Y, Zhang L, Liu H, Du K, Li Z, et al. Coronavirus disease 2019: initial detection on chest CT in a retrospective multicenter study of 103 Chinese patients. Radiology: Cardiothoracic Imaging.
2020;2(2):e200092.
5. Albert JM. Radiation risk from CT: implications for cancer screening. American Journal of Roentgenology. 2013;201(1):W81-W7.
6. Brenner DJ, Hall EJ. Computed tomography—an increasing source of radiation exposure. New England journal of medicine. 2007;357(22):2277-84.
7. Guleria R, Bhushan B, Guleria A, Bhushan A, Dulari P. Harmful effects of ionizing radiation. International Journal for Research in Applied Science & Engineering Technology (IJRASET). 2019;7(12):887-9.
8. Yurdaisik I, Nurili F, Aksoy SH, Agirman AG, Aktan A. Ionizing radiation exposure in patients with COVID-19: More than needed. Radiation Protection Dosimetry. 2021;194(2-3):135-43.
9. National Research Council. Health risks from exposure to low levels of ionizing radiation: 2006, BEIR VII phase 2.
10. Revel M-P, Parkar AP, Prosch H, Silva M, Sverzellati N, Gleeson F, et al. COVID-19 patients and the Radiology department–advice from the European Society of Radiology (ESR) and the European Society of Thoracic Imaging (ESTI). European radiology. 2020;30(9):4903-9.
11. Bahrami-Motlagh H, Abbasi S, Haghighimorad M, Salevatipour B, Darazam IA, Taheri MS, et al. Performance of low-dose chest CT scan for initial triage of COVID-19. Iranian Journal of Radiology. 2020;17(4).
12. Kang Z, Li X, Zhou S. Recommendation of low-dose CT in the detection and management of COVID-2019. European Radiology. 2020;30(8):4356-7.
13. Grant EJ, Brenner A, Sugiyama H, Sakata R, Sadakane A, Utada M, et al. Solid cancer incidence among the life span study of atomic bomb survivors: 1958–2009. Radiation research. 2017;187(5):513-37.
14. De Gonzalez AB, Salotti JA, McHugh K, Little MP, Harbron RW, Lee C, et al. Relationship between paediatric CT scans and subsequent risk of leukaemia and brain tumours: assessment of the impact of underlying conditions. British journal of cancer. 2016;114(4):388-94.
15. de Gonzalez AB, Darby S. Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries. The lancet. 2004;363(9406):345-51.
16. Breast cancer facts. Available: https://www.who.int/news-room/fact-sheets/detail/breast-cancer.
17. Dolatkhah R, Somi MH, Jafarabadi MA, Hosseinalifam M, Sepahi S, Belalzadeh M, et al. Breast cancer survival and incidence: 10 years cancer registry data in
the Northwest, Iran. International journal of breast cancer. 2020;2020.
18. IHME.GBD compare. Available: https://vizhub.healthdata.org/gbd-compare.
19. Preston D, Kitahara C, Freedman D, Sigurdson A, Simon S, Little M, et al. Breast cancer risk and protracted low-to-moderate dose occupational radiation exposure in the US Radiologic Technologists Cohort, 1983–2008. British journal of cancer. 2016;115(9):1105-12.
20. Land CE, Boice Jr JD, Shore RE, Norman JE, Tokunaga M. Breast cancer risk from low-dose exposures to ionizing radiation: results of parallel analysis of three exposed populations of women. Journal of the National Cancer Institute. 1980;65(2):353-76.
21. Boice Jr JD, Land CE, Shore RE, Norman JE, Tokunaga M. Risk of breast cancer following low-dose radiation exposure. Radiology. 1979;131(3):589-97.
22. Pernicka F, McLean I. Dosimetry in diagnostic radiology: an international code of practice: International Atomic Energy Agency; 2007.
23. LARisk Package. Available: https://cran.r-project.org/web/packages/LARisk/vignettes/LARisk-vignette.html.
24. De González AB, Mahesh M, Kim K-P, Bhargavan M, Lewis R, Mettler F, et al. Projected cancer risks from computed tomographic scans performed in the United States in 2007. Archives of internal medicine. 2009;169(22):2071-7.
25. Jamshidi MH, Karami A, Salimi Y, Keshavarz A. Patient effective dose and radiation biological risk in the chest and abdominopelvic computed tomography. Applied Radiation and Isotopes. 2023;193:110628.
26. Lahham A, ALMasri H, Kameel S. Estimation of female radiation doses and breast cancer risk from chest CT examinations. Radiation Protection Dosimetry. 2018;179(4):303-9.
27. Zondervan RL, Hahn PF, Sadow CA, Liu B, Lee SI. Frequent body CT scanning of young adults: indications, outcomes, and risk for radiation-induced cancer. Journal of the American College of Radiology. 2011;8(7):501-7.
| Files | ||
| Issue | Vol 18, No 4 (December 2024) | |
| Section | Original Articles | |
| DOI | https://doi.org/10.18502/jfrh.v18i4.17429 | |
| Keywords | ||
| Breast Cancer High-Resolution Computed Tomography (HRCT) CT Scan Lifetime Attributable Risk COVID-19 | ||
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How to Cite
1.
Sahebi R, Hassanzadeh J, Haghighi R, Lotfi M, Mirahmadizadeh A. Lifetime Attributable Risk for Breast Cancer Induced by High-Resolution Computed Tomography During COVID-19 Pandemic. J Family Reprod Health. 2024;18(4):274-280.
