Original Articles

Risk Factors Associated With Pediatric Asthma Hospitalization: A Retrospective Case-Control Study

Abstract

Objective: To evaluate the risk factors associated with asthma in children hospitalized at Hospital Belen de Trujillo.
Materials and methods: An analytical study of retrospective cases and controls was carried out in which 258 clinical histories of children between 5 to 14 years of age who were hospitalized in the Hospital Belen de Trujillo (HBT) during the period 2015-2019 were included, which were grouped into 129 histories of children who had been hospitalized for asthma (cases) and 129 histories of children hospitalized for a different cause (controls). The frequency distribution will be calculated, the Chi-square statistical test will be used, the odds ratio will be obtained and the 95% confidence interval will be calculated; finally, a multivariate analysis will be performed by means of logistic regression to determine whether the influence of other variables generates a greater risk of developing asthma in children.
Results: The multivariate analysis showed that the factors: cesarean delivery, non-exclusive breastfeeding, history of bronchiolitis, obesity and maternal age together predict 92. 0% of the cases of asthma; however, taking the influence of all the factors at the same time, it was found that the cesarean delivery route, non-exclusive breastfeeding, obesity and maternal age are significant for the regression (p<0.05), while the factor history of bronchiolitis is not significant (p>0.05). Likewise, when the bivariate analysis of the five variables studied was performed and the Chi-square test was applied, it was found that all five factors were significant (p<0.05) for asthma in children at Hospital Belen de Trujillo.
Conclusion: The factors cesarean delivery route, non-exclusive breastfeeding, history of bronchiolitis, obesity and maternal age are associated with asthma in children hospitalized at HBT.

1. Mushtaq A. Asthma in the USA: the good, the bad, and the disparity. Lancet Respir Med. 2018;6(5):335-336.
2. Cotrina K. Control de asma bronquial en niños y adolescentes atendidos en establecimientos de salud de Chiclayo. Revista Cubana de Pediatría. 2020;92(2).
3. Gao H, Miao C, Li H, Bai M, Zhang H, Wu Z, et al. The effects of different parity and delivery mode on wheezing disorders in the children-a retrospective cohort study in Fujian, China. J Asthma. 2022;59(10):1989-1996.
4. Caixia L, Yang X, Yurong T, Xiaoqun Q. Involvement of epigenetic modification in epithelial immune responses during respiratory syncytial virus infection. Microb Pathog. 2019;130:186-189.
5. Brandão HV, Vieira GO, Vieira TO, Cruz ÁA, Guimarães AC, Teles C, et al. Acute viral bronchiolitis and risk of asthma in schoolchildren: analysis of a Brazilian newborn cohort. J Pediatr (Rio J). 2017;93(3):223-229.
6. Rusconi F, Zugna D, Annesi-Maesano I, Baïz N, Barros H, Correia S, et al. Mode of Delivery and Asthma at School Age in 9 European Birth Cohorts. Am J Epidemiol. 2017;185(6):465-473.
7. Tsai HJ, Wang G, Hong X, Yao TC, Ji Y, Radovick S,
et al. Early Life Weight Gain and Development of Childhood Asthma in a Prospective Birth Cohort. Ann Am Thorac Soc. 2018;15(10):1197-1204.
8. Nasiri Kalmarzi R, Ataee P, Mansori M, Moradi G, Ahmadi S, Kaviani Z, et al. Serum levels of adiponectin and leptin in asthmatic patients and its relation with asthma severity, lung function and BMI. Allergol Immunopathol (Madr). 2017;45(3):258-264.
9. Miliku K, Azad MB. Breastfeeding and the Developmental Origins of Asthma: Current Evidence, Possible Mechanisms, and Future Research Priorities. Nutrients. 2018;10(8):995.
10. Wang G, Han D, Jiang Z, Li M, Yang S, Liu L. Association between early bronchiolitis and the development of childhood asthma: a meta-analysis. BMJ Open. 2021;11(5):e043956.
11. Gómez Real F, Burgess JA, Villani S, Dratva J, Heinrich J, Janson C, et al. Maternal age at delivery, lung function and asthma in offspring: a population-based survey. Eur Respir J. 2018;51(6):1601611.
12. Darabi B, Rahmati S, HafeziAhmadi MR, Badfar G, Azami M. The association between caesarean section and childhood asthma: an updated systematic review and meta-analysis. Allergy Asthma Clin Immunol. 2019;15:62.
13. Deng X, Ma J, Yuan Y, Zhang Z, Niu W. Association between overweight or obesity and the risk for childhood asthma and wheeze: An updated meta-analysis on 18 articles and 73 252 children. Pediatr Obes. 2019;14(9):e12532.
14. Clark AJ, Dong N, Roth T, Douglas LC. Factors Associated With Asthma Diagnosis Within Five Years of a Bronchiolitis Hospitalization: A Retrospective Cohort Study in a High Asthma Prevalence Population. Hosp Pediatr. 2019;9(10):794-800.
15. Makrinioti H, Hasegawa K, Lakoumentas J, Xepapadaki P, Tsolia M, Castro-Rodriguez JA, et al. The role of respiratory syncytial virus- and rhinovirus-induced bronchiolitis in recurrent wheeze and asthma-A systematic review and meta-analysis. Pediatr Allergy Immunol. 2022;33(3):e13741.
16. Liang Y, Zhang J, Bai S, Du S, Yang X, Wang Z. Short-term and long-term effects of cesarean section on asthma and wheezing: A cohort study and meta-analysis. Respir Med. 2023;215:107300.
17. Hou W, Guan F, Xia L, Xu Y, Huang S, Zeng P. Investigating the influence of breastfeeding on asthma in children under 12 years old in the UK Biobank. Front Immunol. 2022;13:967101.
18. Aziz DA, Bajwa RA, Viquar W, Siddiqui F, Abbas A. Asthma exacerbations and body mass index in children and adolescents: experience from a tertiary care center. Monaldi Arch Chest Dis. 2023;94(2).
19. Laerum BN, Svanes C, Wentzel-Larsen T, Gulsvik A, Torén K, Norrman E, et al. Young maternal age at delivery is associated with asthma in adult offspring. Respir Med. 2007;101(7):1431-8.
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IssueVol 18, No 4 (December 2024) QRcode
SectionOriginal Articles
DOI https://doi.org/10.18502/jfrh.v18i4.17423
Keywords
Asthma Risk Factors Child

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1.
Luna Muñoz LG, Revoredo Llanos S, Ordaya-Gonzales K, Arriola-Montenegro L, Chaponan-Lavalle A, Arriola-Montenegro J. Risk Factors Associated With Pediatric Asthma Hospitalization: A Retrospective Case-Control Study. J Family Reprod Health. 2024;18(4):235-239.