Comparison of Two Different Injectable Contraceptive Methods: Depo-medroxy Progesterone Acetate (DMPA) and Cyclofem

  • Firoozeh Veisi Mail Department of Obstetrics & Gynecology, High Risk Pregnancy Research Center, Kermanshah University of Medical Science, Kermanshah, Iran.
  • Maryam Zangeneh Department of Obstetrics & Gynecology, High Risk Pregnancy Research Center, Kermanshah University of Medical Science, Kermanshah, Iran.
Cyclofem, Depo-Provera, Injectable Contraceptives, Side Effects


Objective: To compare side effects between users of two kinds of injectable contraceptives (Depo-medroxy progesterone acetate and Cyclofem).
Materials and methods: This cross-sectional descriptive study included 250 women, aged 18-40 years, using Depo-medroxy progesterone acetate (DMPA) or Cyclofem. The volunteers were examined six months after using contraceptive, and they were asked about following symptoms: weight changes, irregular bleeding, dysparounia, vaginal dryness, headache, breast pain, bone pain, and discontinuation reason. The data were analyzed by statistical methods.
Results: The important side effects of DMPA were: irregular bleeding (93.60%), weight gain (48%), bone pain (24%) and vaginal dryness (10.40%), while the side effects in the Cyclofem group were: irregular bleeding (65.60%), headache (14.4%) and breast sensitivity (20%). Bleeding pattern changes were the most important problem leading to discontinuation of both contraceptive methods in our participants.
Conclusion: The results of the study showed that the most important problem in both groups was change in bleeding pattern. Proper consulting by a trained expert reduces the high amount of discontinuation and their failure rates.


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How to Cite
Veisi F, Zangeneh M. Comparison of Two Different Injectable Contraceptive Methods: Depo-medroxy Progesterone Acetate (DMPA) and Cyclofem. J Fam Reprod Health. 7(3):109-13.
Original Articles