Clomiphene Citrate Challenge Test and Prediction of Outcome in IVF
,
Abstract
Objective: The aim of this study was to assess the accuracy of ovarian reserve tests, mainly basal and clomiphene stimulated follicle stimulating hormone (FSH) concentrations.
Materials and methods: A prospective cohort study was conductedon 120 infertile patients referring to Mirza Koochak Khan Hospital for IVFfrom 2004 to 2006. All the patients underwent clomiphene citrate challenge test (CCCT) and then in vitro fertilization (IVF) was performed. We evaluated predictive power of CCCT to find IVF outcome in women with decreased ovarian reserve in comparison to those who have appropriate ovarian reserve. SPSS 12 was used to analyze the data of this study via student t test, Fisher exact, Chi -square tests and logistic regression analysis.
Results: IVF success rate was 11.7% and CCCT sensitivity and specificity were 30.2% and 92.9% while its positive and negative predictive values were 14.9% and 97% respectively.
Conclusion:CCCT is a good test in estimating ovarian reserve. Due to its high negative predictive value, lower chance of pregnancy is expected in the cases with abnormal results.
Speroff L. Textbook of Clinical Gynecologic, Endocrinology and Infertility. 7 th ed. Lippincott Williams and Wilkins, 2005; 1013-274.
Winslow KL, Toner JP, Brzyski RG, Oehninger SC, Acosta AA, Muasher SJ. The gonadotropin-releasing hormone agonist stimulation test--a sensitive predictor of performance in the flare-up in vitro fertilization cycle. Fertil Steril 1991;56:711-7.
Hendriks DJ, Broekmans FJ, Bancsi LF, de Jong FH, Looman CW, Te Velde ER. Repeated clomiphene citrate challenge testing in the prediction of outcome in IVF: a comparison with basal markers for ovarian reserve. Hum Reprod 2005;20:163-9.
Kwee J, Schats R, McDonnell J, Lambalk CB, Schoemaker J. Intercycle variability of ovarian reserve tests: results of a prospective randomized study. Hum Reprod 2004;19:590-5.
Ng EH, Chan CC, Tang OS, Ho PC. Antral follicle count and FSH concentration after clomiphene citrate challenge test in the prediction of ovarian response during IVF treatment. Hum Reprod 2005; 20:1647- 54.
Csemiczky G, Harlin J, Fried G. Predictive power of clomiphene citrate challenge test for failure of in vitro fertilization treatment. Acta Obstet Gynecol Scand 2002;81:954-61.
| Files | ||
| Issue | Vol 2, No 1 (March 2008) | |
| Section | Original Articles | |
| Keywords | ||
| Clomiphene Citrate Challenge test Pregnancy IVF Infertility | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
