Malignancy Arising in Dermoid Cysts: A Case Report and Literature Review
-
Maliheh Arab
,
Azadeh Jafari Ashtiani
,
Nafiseh Faghih
,
Behnaz Ghavami
,
Behnaz Nouri
,
Shahla Noori Ardabili
Abstract
Objective: Malignant transformation in dermoid cysts is rare, and Squamous Cell Carcinoma (SCC) is the most common form. This event often occurs in large tumors and middle-aged women.
Case report: In this study, two cases are presented. They were menopause, and abdominal pain and adnexal mass was a common manifestation in both. Case 1 with adenocarcinoma arising in mature cystic teratoma had abnormal tumor markers and was diagnosed with a frozen section during surgery, but case 2 with SCC transformation had normal tumor markers, and the frozen section was not helpful in the first surgery. Both underwent complete staging surgery, and due to stage IC1 in case 1, she received chemotherapy, and in case 2, no adjuvant treatment was needed because of stage IA.
Conclusion: Considering the rarity of malignant transformation in the dermoid cyst, the best surgical approach and adjuvant therapy indications need further research
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3. Bonahy AA, Sabbah H, Vadell AH, Baba NE. Malignant teratoma: about a case and a review of the literature. The Pan African Medical Journal. 2017;27:61.
4. Akazawa M, Onjo S. Malignant transformation of mature cystic teratoma: is squamous cell carcinoma different from the other types of Neoplasm?. Int J Gynecol Cancer. 2018 ;28(9):1650-1656.
5. Esterson YB, Gaballah M, Grimaldi GM, Raj MH, Pellerito JS. Ovarian dermoid cyst complicated by small bowel obstruction, entero-ovarian fistula formation, and malignant degeneration. Clin Imaging. 2019;56:47-51.
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7. Tehranian A, Ghahghaei-Nezamabadi A, Seifollahi A, Kasraei S, Dehghani-Nejad H, Maleki-Hajiagha A. Ovarian mature cystic teratoma with malignant transformation: two case reports. J Med Case Rep. 2021;15(1):23.
8. Tazo Y, Yoshimura Y, Shoda T, Kyushima N, Okada T, Yamazaki H. Relevance of frozen sections and serum markers in invasive squamous cell carcinoma arising from ovarian mature cystic teratoma: two case reports. J Med Case Rep. 2016; 10: 20.
9. Hurwitz JL, Fenton A, McCluggage WG, McKenna S. Squamous cell carcinoma arising in a dermoid cyst of the ovary: a case series. BJOG. 2007;114(10):1283-7.
10. Al-Rayyan ES, Duqoum WJ, Sawalha MS, Nascimento
MC, Pather S, Dalrymple CJ, et al. Secondary malignancies in ovarian dermoid cyst. Saudi Med J. 2009;30(4):524-8.
11. Li C, Zhang Q, Zhang S, Dong R, Sun C, Qiu C, et al. Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review. BMC Cancer. 2019;19(1):217.
12. Li X, Tang X, Zhuo W. Malignant transformation of ovarian teratoma responded well to immunotherapy after failed chemotherapy: a case report. Annals of Palliative Medicine. 2021;10(7):8499-505.
13. Qin L, Zhao T, Liu X, Wang H, Gu X, Chen D, et al. Malignant transformation arising from mature ovarian cystic teratoma: A case series. Medicine (Baltimore). 2021;100(13):e24726.
14. Mahtate M, Talib S, Slaoui A, Zeraidi N, Lakhdar A, Rhrab B, et al. Malignant Degeneration of a Mature Ovarian Teratoma. Case Rep Obstet Gynecol. 2021; 2021:5527467.
15. Rathore R, Sharma S, Agarwal S. Malignant transformation in mature cystic teratoma of the ovary: a retrospective study of eight cases and review of
literature. Prz Menopauzalny. 2018;17(2):63-8.
16. Shimada T, Higashijima A, Fukushima A, Komatsu N, Noguchi M, Ohashi K, et al. Malignant transformation from mature cystic teratoma of the ovary. J Obstet Gynaecol Res. 2019;45(9):1957-1960.
17. Jitsumori M, Munakata S, Yamamoto T. Malignant Transformation of Mature Cystic Teratoma Diagnosed after a 10-Year Interval. Case Rep Obstet Gynecol. 2017;2017:2947927.
18. Shafizadeh F, Babazadeh S, Nasiri Amiri F, Shafizadeh A. Squamous Cell Carcinoma in the Shadow of the Mature Cystic Teratoma of the Ovary: A Case Report. Journal of Obstetrics, Gynecology and Cancer Research. 2021;6(4):233-8.
2. Moussaoui E, Closon F, Brichant G, Kotzampassakis N, Nisolle M. Chemical peritonitis complicating the spontaneous rupture of a dermoid cyst of the ovary. Rev Med Liege. 2018;73(7-8):413-8.
3. Bonahy AA, Sabbah H, Vadell AH, Baba NE. Malignant teratoma: about a case and a review of the literature. The Pan African Medical Journal. 2017;27:61.
4. Akazawa M, Onjo S. Malignant transformation of mature cystic teratoma: is squamous cell carcinoma different from the other types of Neoplasm?. Int J Gynecol Cancer. 2018 ;28(9):1650-1656.
5. Esterson YB, Gaballah M, Grimaldi GM, Raj MH, Pellerito JS. Ovarian dermoid cyst complicated by small bowel obstruction, entero-ovarian fistula formation, and malignant degeneration. Clin Imaging. 2019;56:47-51.
6. Black JD, Roque DM, Pasternak MC, Buza N, Rutherford TJ, Schwartz PE, et al. A series of malignant ovarian cancers arising from within a mature cystic teratoma: a single institution experience. Int J Gynecol Cancer. 2015 ;25(5):792-7.
7. Tehranian A, Ghahghaei-Nezamabadi A, Seifollahi A, Kasraei S, Dehghani-Nejad H, Maleki-Hajiagha A. Ovarian mature cystic teratoma with malignant transformation: two case reports. J Med Case Rep. 2021;15(1):23.
8. Tazo Y, Yoshimura Y, Shoda T, Kyushima N, Okada T, Yamazaki H. Relevance of frozen sections and serum markers in invasive squamous cell carcinoma arising from ovarian mature cystic teratoma: two case reports. J Med Case Rep. 2016; 10: 20.
9. Hurwitz JL, Fenton A, McCluggage WG, McKenna S. Squamous cell carcinoma arising in a dermoid cyst of the ovary: a case series. BJOG. 2007;114(10):1283-7.
10. Al-Rayyan ES, Duqoum WJ, Sawalha MS, Nascimento
MC, Pather S, Dalrymple CJ, et al. Secondary malignancies in ovarian dermoid cyst. Saudi Med J. 2009;30(4):524-8.
11. Li C, Zhang Q, Zhang S, Dong R, Sun C, Qiu C, et al. Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review. BMC Cancer. 2019;19(1):217.
12. Li X, Tang X, Zhuo W. Malignant transformation of ovarian teratoma responded well to immunotherapy after failed chemotherapy: a case report. Annals of Palliative Medicine. 2021;10(7):8499-505.
13. Qin L, Zhao T, Liu X, Wang H, Gu X, Chen D, et al. Malignant transformation arising from mature ovarian cystic teratoma: A case series. Medicine (Baltimore). 2021;100(13):e24726.
14. Mahtate M, Talib S, Slaoui A, Zeraidi N, Lakhdar A, Rhrab B, et al. Malignant Degeneration of a Mature Ovarian Teratoma. Case Rep Obstet Gynecol. 2021; 2021:5527467.
15. Rathore R, Sharma S, Agarwal S. Malignant transformation in mature cystic teratoma of the ovary: a retrospective study of eight cases and review of
literature. Prz Menopauzalny. 2018;17(2):63-8.
16. Shimada T, Higashijima A, Fukushima A, Komatsu N, Noguchi M, Ohashi K, et al. Malignant transformation from mature cystic teratoma of the ovary. J Obstet Gynaecol Res. 2019;45(9):1957-1960.
17. Jitsumori M, Munakata S, Yamamoto T. Malignant Transformation of Mature Cystic Teratoma Diagnosed after a 10-Year Interval. Case Rep Obstet Gynecol. 2017;2017:2947927.
18. Shafizadeh F, Babazadeh S, Nasiri Amiri F, Shafizadeh A. Squamous Cell Carcinoma in the Shadow of the Mature Cystic Teratoma of the Ovary: A Case Report. Journal of Obstetrics, Gynecology and Cancer Research. 2021;6(4):233-8.
| Files | ||
| Issue | Vol 17, No 4 (December 2023) | |
| Section | Case Reports | |
| DOI | https://doi.org/10.18502/jfrh.v17i4.14599 | |
| Keywords | ||
| Dermoid Cysts Ovarian Neoplasms Malignant Transformation | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Arab M, Jafari Ashtiani A, Faghih N, Ghavami B, Nouri B, Noori Ardabili S. Malignancy Arising in Dermoid Cysts: A Case Report and Literature Review. J Family Reprod Health. 2023;17(4):264-268.
