The Value of Chlamydia Trachomatis Antibody Testing in Prediction of Tubal Factor Infertility
,
Abstract
Objective: This study aimed to assess the value of Chlamydia trachomatis (C.trachomatis) antibodytiter test in prediction of tubal damage.
Materials and Methods: In this case-control study we enrolled50 women with tubal factor infertility (proven by laparoscopy after hysterosalpingography) and 110 women without infertility history. ELISA was performed for all participants, seeking C.trachomatis IgG antibodies. ELISA for IgM was then performed for women with positive test. Statistical package for social science version 11 was used for data entry. Statistical evaluation was performed using student t test, Fisher exact and chi-square tests. Statistical significance was defi ned as P<0.05.
Results: In 8(5%) of all women the C.trachomatis IgG antibodywas positive .Five (10%) of the infertilepatients and 3 (2.7%) of pregnant women had positive tests (P < 0.03). All of them had negative results for IgM antibodies. Twenty five percent of women with normal hysterosalpingography and 5.3% of women with abnormal hysterosalpingography had positive antibody test. There was not any correlation between antibody titer and abnormal HSG. Endometriosis was diagnosed in seven women with negative antibody results.
Conclusion: The result of C.trachomatis antibody titer was significantly different in women with and without infertility Laparoscopic. Tubalassessment is recommended in infertile women with a positive result of theC. trachomatis antibody titer.
Dabekausen YA, Evers JL, Land JA, Stals FS. Chlamydia trachomatis antibody testing is more accurate than hysterosalpingography in predicting tubal factor infertility. Fertil Steril 1994;61:833–7.
Gray-Swain MR, Peipert JF. Pelvic inflammatory disease in adolescents. Curr Opin Obstet Gynecol 2006;18:503-10.
Vegheş S, Lupaşcu I, Solomiţchi V, Duca E, Fochi M. Chlamydia infections and tubal infertility. Rev Med Chir Soc Med Nat Iasi 2004; 108: 617-23.
Spiliopoulou A, Lakiotis V, Vittoraki A, Zavou D, Mauri D. Chlamydia trachomatis : time for screening? Clin Microbiol Infect 2005;11:687-9.
Swart P, Mol BW, van der Veen F, van Beurden M, Redekop WK, Bossuyt PM.The accuracy of hystero-salpingography in the diagnosis of tubal pathology: a meta-analysis. Fertil Steril 1995; 64: 486-91.
Corson SL. The role of laparoscopy in the infertility work-up. J Reprod Med 1977; 18: 127–31.
Moore DE, Spadoni LR, Foy HM, Wang SP, Daling JR, Kuo CC, et al . Increased frequency of serum antibodies to Chlamydia trachomatis in infertility due to distal tubal disease. Lancet 1982; 2: 574-7.
den Hartog JE, Morre SA, Land JA. Chlamydia trachomatis-associated tubal factor subfertility: Immunogenetic aspects and serological screening. Hum Reprod Update 2006;12:719-30.
den Hartog JE, Land JA, Stassen FR, Kessels AG, Bruggeman CA. Serological markers of persistent C.trachomatis infections in women with tubal factor subfertility. Hum Reprod 2005;20:986-90.
Veenemans LM, van der Linden PJ. The value of Chlamydia trachomatis antibody testing in predicting tubal factor infertility. Hum Reprod 2002;17:695-8.
Meikle SF, Zhang X, Marine WM, Calonge BN, Hamman RF, Betz G. Chlamydia trachomatis antibody titers and hysterosalpingography in predicting tubal disease in infertility patients. Fertil Steril 1994; 62: 305-12.
Tanikawa M, Harada T, Katagiri C, Onohara Y, Yoshida S, Terakawa N. Chlamydia trachomatis antibody titres by enzyme-linked immunosorbent assay are useful in predicting severity of adnexal adhesion. Hum Reprod 1996;11:2418-21.
Sheffield PA, Moore DE, Voigt LF, Scholes D, Wang SP, Grayston JT, et al. The association between Chlamydia trachomatis serology and pelvic damage in women with tubal ectopic gestations. Fertil Steril 1993; 60:970-5. Erratum in: Fertil Steril 1994; 61(5): 995.
Land JA, Evers JL, Goossens VJ. How to use Chlamydia antibody testing in subfertility patients. Hum Reprod 1998;13:1094-8.
Thomas K, Coughlin L, Mannion PT, Haddad NG. The value of Chlamydia trachomatis antibody testing as part of routine infertility investigations. Hum Reprod 2000;15:1079-82.
Puolakkainen M, Vesterinen E, Purola E, Saikku P, Paavonen J. Persistence of chlamydial antibodies after pelvic inflammatory disease. J Clin Microbiol 1986;23:924-8.
Gijsen AP, Land JA, Goossens VJ, Slobbe ME, Bruggeman CA. Chlamydia antibody testing in screening for tubal factor subfertility: the significance of IgG antibody decline over time. Hum Reprod 2002; 17: 699-703.
| Files | ||
| Issue | Vol 2, No 1 (March 2008) | |
| Section | Original Articles | |
| Keywords | ||
| Chlamydia trachomatis antibody Hysterosalpingography Laparoscopy Tubal damage | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
