Evaluation of Maternal Urinary Tract Infection as a Potential Risk Factor for Neonatal Urinary Tract Infection
Objective: To assess the relationship between maternal UTI during pregnancy and neonatal UTI.
Materials and methods:This cross-sectional study included eighty neonates referred to Ali-e-Asghar Hospital, Tehran, Iran, in 2011. The participants were divided into the study (with diagnosis of UTI; n = 40) and the control (without this type of infection; n = 40) groups. The mothers were asked about the history of UTI during pregnancy, and if the response was positive, the trimester in which UTI had occurred. Urinalysis and urine culture were carried out for all neonates.Overall, 14.9% of neonates had mothers with a positive history of UTI during their pregnancy (4.4%, 6.1%, and 4.4% during the 1(st), 2(nd), and 3(rd) trimesters, respectively). A significant relationship was detected between the occurrence of UTI in neonates and maternal UTI, so that the overall prevalence of UTI among neonates of affected mothers was significantly higher than that observed among non-infected mothers (30.0% versus 6.8%; p = 0.001). Maternal UTI resulted in 5.9-fold increased risk of neonatal UTI. In UTI group, the most common bacterial etiologies of UTI were Escherichia coli (65.9%), followed by Klebsiella (14.6%) and Staphylococci (9.8%).
Conclusion: Our findings confirmed the association between the history of UTI in mother and occurrence of UTI in neonate, emphasizing to pay more attention for assessing and managing UTI in neonates in order to reduce the related complications.
Delzell JE Jr, Lefevre ML. Urinary tract infections during pregnancy. Am Fam Physician 2000; 61:713-21.
Brumfitt W. The effects of bacteriuria in pregnancy on maternal and fetal health. Kidney Int Suppl 1975; 4: S113-9.
McGrady GA, Daling JR, Peterson DR. Maternalurinary tract infection and adverse fetal outcomes. Am J Epidemiol 1985; 121:377-81.
Sastre JB, Aparicio AR, Cotallo GD, Colomer BF, Hernández MC; Grupo de Hospitales Castrillo. Urinary tract infection in the newborn: clinical and radio imaging studies. Pediatr Nephrol 2007; 22:1735-41.
Eliakim A, Dolfin T, Korzets Z, Wolach B, Pomeranz A. Urinary tract infection in premature infants: the role of imaging studies and prophylactic therapy. J Perinatol 1997; 17:305-8.
Garcia FJ, Nager AL. Jaundice as an early diagnostic sign of urinary tract infection in infancy. Pediatrics 2002; 109:846-51.
Khalesi N, Shahraki T, Haghighi M. Prevalence of urinary tract infection in neonates with prolonged jaundice referred to Aliasghar Hospital in Zahedan (2005). J Qazvin Univ Med Sci 2007; 11:14-8.
Emamghorashi F, Mahmoodi N, Tagarod Z, HeydariST. Maternal urinary tract infection as a risk factor for neonatal urinary tract infection. Iran J Kidney Dis 2012; 6:178-80.
Mazor-Dray E, Levy A, Schlaeffer F, Sheiner E.Maternal urinary tract infection: is it independently associated with adverse pregnancy outcome? J Matern Fetal Neonatal Med 2009; 22:124-8.
Falcão MC, Leone CR, D'Andrea RA, Berardi R, Ono NA, Vaz FA. Urinary tract infection in full-term newborn infants: risk factor analysis. Rev Hosp Clin Fac Med Sao Paulo 2000; 55:9-16.
Saffar MJ, Enayti AA, Abdolla IA, Razai MS, Saffar H. Antibacterial susceptibility of uropathogens in 3 hospitals, Sari, Islamic Republic of Iran, 2002-2003. East Mediterr Health J 2008; 14:556-63.
Zorc JJ, Levine DA, Platt SL, Dayan PS, Macias CG, Krief W, Et al. Clinical and demographic factors associated with urinary tract infection in young febrile infants. Pediatrics 2005; 116:644-8.
Shaw KN, McGowan KL, Gorelick MH, Schwartz JS.Screening for urinary tract infection in infants in the emergency department: which test is best? Pediatrics 1998; 101:1-5.
Feld LG, Greenfield SP, Ogra PL. Urinary tract infections in infants and children. Pediatr Rev 1989;11:71-7.
Friedman S, Shah V, Ohlsson A, Matlow AG.Neonatal escherichia coli infections: concerns regarding resistance to current therapy. Acta Paediatr 2000; 89:686-9.
Joseph TA, Pyati SP, Jacobs N. Neonatal early-onset Escherichia coli disease. The effect of intrapartum ampicillin. Arch Pediatr Adolesc Med 1998; 152:35-40.
Towers CV, Carr MH, Padilla G, Asrat T. Potential consequences of widespread antepartal use of ampicillin. Am J Obstet Gynecol 1998; 179:879-83.
|Issue||Vol 8, No 2 (June 2014)|
|Mother Neonate Pregnancy Risk Urinary Tract Infection|
|Rights and permissions|
|This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.|