Evaluation of Ovarian Reserve in Women With Rheumatoid Arthritis
-
Sara Patricia Peña-Lizola
,
Luis Humberto Sordia-Hernandez
,
Selene Marysol Garcia-Luna
,
Otto Valdes-Martinez
,
Cassandra Michele Skinner-Taylor
,
Mario Alberto Garza-Elizondo
,
OScar Vidal-Gutierrez
,
Jesus Zacarias Villarreal-Perez
,
Miryam Eguia-Bernal
,
Felipe Arturo Morales-Martinez
Abstract
Objective: Subfertility is commonly observed in patients with rheumatoid arthritis (RA). Although the causes are not well established, the alteration of the ovarian reserve is thought to contribute to the lower chances of pregnancy. This cross-sectional study aimed to evaluate the ovarian reserve in patients with RA.
Materials and methods: Two parameters associated with ovarian reserves such as the antral follicle count (AFC) and the anti-müllerian hormone (AMH) were assessed in 38 patients with RA. We also analyzed the correlation of these parameters with the medication used to treat this pathology and with the illness severity.
Results: The AMH levels in women with RA were comparable to those found on healthy individuals although the RA patients were more likely to have a low AFC. Ovarian reserve and RA were neither influenced by parameters of disease activity nor by the use of medication.
Conclusion: The ovarian reserve in women with RA was similar to that found in healthy individuals.
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2. Grynnerup AG, Lindhard A, Sørensen S. The role of anti-Müllerian hormone in female fertility and infertility - An overview. Acta Obstet Gynecol Scand 2012; 91: 1252–60.
3. Pankhurst MW, Chong YH, McLennan IS. Enzyme-linked immunosorbent assay measurements of antimüllerian hormone (AMH) in human blood are a composite of the uncleaved and bioactive cleaved forms of AMH. Fertil Steril 2014; 101: 846-50.
4. Kruszynska A, Slowinska-Srzednicka J. Anti-Müllerian hormone (AMH) as a good predictor of time of menopause. Prz Menopauzalny 2017; 16: 47-50.
5. van Riel PL, Renskers L. The Disease Activity Score (DAS) and the Disease Activity Score using 28 joint counts (DAS28) in the management of rheumatoid arthritis. Clin Exp Rheumatol 2016; 34: S40-S44.
6. Bullock J, Rizvi SAA, Saleh AM, Ahmed SS, Do DP, Ansari RA, et al. Rheumatoid arthritis: A brief overview of the treatment. Med Princ Pract 2018; 27: 501-7.
7. Otón T, Carmona L. The epidemiology of established rheumatoid arthritis. Best Pract Res Clin Rheumatol 2019; 33: 101477.
8. Lucas CJ, Dimmitt SB, Martin JH. Optimising low‐dose methotrexate for rheumatoid arthritis-A review. Br J Clin Pharmacol 2019; 85: 2228–34.
9. Jawaheer D, Zhu JL, Nohr EA, Olsen J. Time to pregnancy among women with rheumatoid arthritis. Arthritis Rheum 2011; 63: 1517-21.
10. Clowse ME, Chakravarty E, Costenbader KH, Chambers C, Michaud K. Effects of infertility, pregnancy loss, and patient concerns on family size of women with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Care Res (Hoboken) 2012; 64: 668-74.
11. Del Junco DJ, Annegers JF, Coulam CB, Luthra HS. The Relationship between Rheumatoid Arthritis and Reproductive Function. Br J Rheumatolo 1989; 28 Suppl 1: 33.
12. Brouwer J, Laven JS, Hazes JM, Schipper I, Dolhain RJ. Levels of Serum Anti-Müllerian Hormone, a Marker for Ovarian Reserve, in Women With Rheumatoid Arthritis. Arthritis Care Res (Hoboken) 2013; 65: 1534–8.
13. Henes M, Froeschlin J, Taran FA, Brucker S, Rall KK, Xenitidis T, et al. Ovarian reserve alterations in premenopausal women with chronic inflammatory rheumatic diseases: impact of rheumatoid arthritis, Behçet’s disease and spondyloarthritis on anti-Müllerian hormone levels. Rheumatology (Oxford) 2015; 54: 1709–12.
14. Brouwer J, Dolhain RJEM, Hazes JMW, Visser JA, Laven JSE. Reduced Ovarian Function in Female Rheumatoid Arthritis Patients Trying to Conceive. ACR Open Rheumatol 2019; 1: 327–35.
15. Jirge PR. Poor ovarian reserve. J Hum Reprod Sci 2016; 9: 63-9.
16. Verma AK, Rajbhar S, Mishra J, Gupta M, Sharma M, Deshmukh G, et al. Anti-mullerian hormone: A marker of ovarian reserve and its association with polycystic ovarian syndrome. J Clin Diagn Res 2016; 10: QC10–QC12.
17. Practice Committee of the American Society for Reproductive Medicine. Testing and interpreting measures of ovarian reserve: a committee opinion. Fertil Steril 2015; 103: e9-e17.
18. Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril 2014; 102: 460-8.e3.
19. Anagnostis P, Karras S, Goulis DG. Vitamin D in human reproduction: A narrative review. Int J Clin Pract 2013; 67: 225-35.
20. Kebapcilar AG, Kulaksizoglu M, Kebapcilar L, Gonen MS, Ünlü A, Topcu A, et al. Is there a link between premature ovarian failure and serum concentrations of vitamin D, zinc, and copper? Menopause 2013; 20: 94-9.
21. Pearce K, Gleeson K, Tremellen K. Serum anti-Mullerian hormone production is not correlated with seasonal fluctuations of Vitamin D status in ovulatory or PCOS women. Hum Reprod 2015; 30: 2171-7.
22. Cutolo M, Otsa K, Uprus M, Paolino S, Seriolo B. Vitamin D in rheumatoid arthritis. Autoimmun Rev 2007; 7: 59-64.
23. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010; 62: 2569-81.
24. Wielders Wielders JP, Carter GF, Eberl H, Morris G, Roth HJ, Vogl C. Automated Competitive Protein-Binding Assay for Total 25-OH Vitamin D, Multicenter Evaluation and Practical Performance. J Clin Lab Anal 2015; 29: 451-61.
25. Jayaprakasan K, Narkwichean A, Maalouf WE, Campbell BK. Efficacy of dehydroepiandrosterone to overcome the effect of ovarian ageing (DITTO): a proof of principle randomised controlled trial protocol. BMJ Open 2014; 4: e005767.
26. Conway GS, Kaltsas G, Patel A, Davies MC, Jacobs HS. Characterization of idiopathic premature ovarian failure. Fertil Steril 1996; 65: 337–41.
27. Eudy AM, McDaniel G, Hurd WW, Clowse MEB. Fertility and Ovarian Reserve among Women with Rheumatoid Arthritis. J Rheumatol 2019; 46: 455–9.
28. Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 2004; 50: 380–6.
29. Sekhon L, Rodriguez-Purata J, Lee JA, Whitehouse MC, Copperman AB. Methotrexate treatment of ectopic pregnancy does not impact ovarian reserve or clinical outcome, regardless of the duration of time since exposure. Fertil Steril 2016; 106: supplement e88.
30. Connell AB, Jenkins N, Black M, Pasco JA, Kotowicz MA, Schneider HG. Overreporting of vitamin D deficiency with the Roche Elecsys Vitamin D3
(25-OH) method. Pathology 2011; 43: 368-71.
2. Grynnerup AG, Lindhard A, Sørensen S. The role of anti-Müllerian hormone in female fertility and infertility - An overview. Acta Obstet Gynecol Scand 2012; 91: 1252–60.
3. Pankhurst MW, Chong YH, McLennan IS. Enzyme-linked immunosorbent assay measurements of antimüllerian hormone (AMH) in human blood are a composite of the uncleaved and bioactive cleaved forms of AMH. Fertil Steril 2014; 101: 846-50.
4. Kruszynska A, Slowinska-Srzednicka J. Anti-Müllerian hormone (AMH) as a good predictor of time of menopause. Prz Menopauzalny 2017; 16: 47-50.
5. van Riel PL, Renskers L. The Disease Activity Score (DAS) and the Disease Activity Score using 28 joint counts (DAS28) in the management of rheumatoid arthritis. Clin Exp Rheumatol 2016; 34: S40-S44.
6. Bullock J, Rizvi SAA, Saleh AM, Ahmed SS, Do DP, Ansari RA, et al. Rheumatoid arthritis: A brief overview of the treatment. Med Princ Pract 2018; 27: 501-7.
7. Otón T, Carmona L. The epidemiology of established rheumatoid arthritis. Best Pract Res Clin Rheumatol 2019; 33: 101477.
8. Lucas CJ, Dimmitt SB, Martin JH. Optimising low‐dose methotrexate for rheumatoid arthritis-A review. Br J Clin Pharmacol 2019; 85: 2228–34.
9. Jawaheer D, Zhu JL, Nohr EA, Olsen J. Time to pregnancy among women with rheumatoid arthritis. Arthritis Rheum 2011; 63: 1517-21.
10. Clowse ME, Chakravarty E, Costenbader KH, Chambers C, Michaud K. Effects of infertility, pregnancy loss, and patient concerns on family size of women with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Care Res (Hoboken) 2012; 64: 668-74.
11. Del Junco DJ, Annegers JF, Coulam CB, Luthra HS. The Relationship between Rheumatoid Arthritis and Reproductive Function. Br J Rheumatolo 1989; 28 Suppl 1: 33.
12. Brouwer J, Laven JS, Hazes JM, Schipper I, Dolhain RJ. Levels of Serum Anti-Müllerian Hormone, a Marker for Ovarian Reserve, in Women With Rheumatoid Arthritis. Arthritis Care Res (Hoboken) 2013; 65: 1534–8.
13. Henes M, Froeschlin J, Taran FA, Brucker S, Rall KK, Xenitidis T, et al. Ovarian reserve alterations in premenopausal women with chronic inflammatory rheumatic diseases: impact of rheumatoid arthritis, Behçet’s disease and spondyloarthritis on anti-Müllerian hormone levels. Rheumatology (Oxford) 2015; 54: 1709–12.
14. Brouwer J, Dolhain RJEM, Hazes JMW, Visser JA, Laven JSE. Reduced Ovarian Function in Female Rheumatoid Arthritis Patients Trying to Conceive. ACR Open Rheumatol 2019; 1: 327–35.
15. Jirge PR. Poor ovarian reserve. J Hum Reprod Sci 2016; 9: 63-9.
16. Verma AK, Rajbhar S, Mishra J, Gupta M, Sharma M, Deshmukh G, et al. Anti-mullerian hormone: A marker of ovarian reserve and its association with polycystic ovarian syndrome. J Clin Diagn Res 2016; 10: QC10–QC12.
17. Practice Committee of the American Society for Reproductive Medicine. Testing and interpreting measures of ovarian reserve: a committee opinion. Fertil Steril 2015; 103: e9-e17.
18. Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril 2014; 102: 460-8.e3.
19. Anagnostis P, Karras S, Goulis DG. Vitamin D in human reproduction: A narrative review. Int J Clin Pract 2013; 67: 225-35.
20. Kebapcilar AG, Kulaksizoglu M, Kebapcilar L, Gonen MS, Ünlü A, Topcu A, et al. Is there a link between premature ovarian failure and serum concentrations of vitamin D, zinc, and copper? Menopause 2013; 20: 94-9.
21. Pearce K, Gleeson K, Tremellen K. Serum anti-Mullerian hormone production is not correlated with seasonal fluctuations of Vitamin D status in ovulatory or PCOS women. Hum Reprod 2015; 30: 2171-7.
22. Cutolo M, Otsa K, Uprus M, Paolino S, Seriolo B. Vitamin D in rheumatoid arthritis. Autoimmun Rev 2007; 7: 59-64.
23. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010; 62: 2569-81.
24. Wielders Wielders JP, Carter GF, Eberl H, Morris G, Roth HJ, Vogl C. Automated Competitive Protein-Binding Assay for Total 25-OH Vitamin D, Multicenter Evaluation and Practical Performance. J Clin Lab Anal 2015; 29: 451-61.
25. Jayaprakasan K, Narkwichean A, Maalouf WE, Campbell BK. Efficacy of dehydroepiandrosterone to overcome the effect of ovarian ageing (DITTO): a proof of principle randomised controlled trial protocol. BMJ Open 2014; 4: e005767.
26. Conway GS, Kaltsas G, Patel A, Davies MC, Jacobs HS. Characterization of idiopathic premature ovarian failure. Fertil Steril 1996; 65: 337–41.
27. Eudy AM, McDaniel G, Hurd WW, Clowse MEB. Fertility and Ovarian Reserve among Women with Rheumatoid Arthritis. J Rheumatol 2019; 46: 455–9.
28. Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 2004; 50: 380–6.
29. Sekhon L, Rodriguez-Purata J, Lee JA, Whitehouse MC, Copperman AB. Methotrexate treatment of ectopic pregnancy does not impact ovarian reserve or clinical outcome, regardless of the duration of time since exposure. Fertil Steril 2016; 106: supplement e88.
30. Connell AB, Jenkins N, Black M, Pasco JA, Kotowicz MA, Schneider HG. Overreporting of vitamin D deficiency with the Roche Elecsys Vitamin D3
(25-OH) method. Pathology 2011; 43: 368-71.
| Files | ||
| Issue | Vol 15, No 4 (December 2021) | |
| Section | Original Articles | |
| DOI | https://doi.org/10.18502/jfrh.v15i4.7889 | |
| Keywords | ||
| Ovarian Reserve Anti-Mullerian Hormone Rheumatoid Arthritis | ||
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How to Cite
1.
Peña-Lizola S, Sordia-Hernandez L, Garcia-Luna S, Valdes-Martinez O, Skinner-Taylor C, Garza-Elizondo M, Vidal-Gutierrez O, Villarreal-Perez J, Eguia-Bernal M, Morales-Martinez F. Evaluation of Ovarian Reserve in Women With Rheumatoid Arthritis. J Family Reprod Health. 2021;15(4):236-241.
