Endometrial Serous Carcinoma Arising from Adenomyosis: A Clinico-Pathological Insight
Abstract
Objective: Endometrial cancer (EC) is the most commonly diagnosed malignancy and has the second-highest mortality rate among gynecological cancers. Adenomyosis is well-known for abnormal uterine bleeding and is a widely reported entity; however, an EC arising from the adenomyosis is a rare event; even rarer is the occurrence of serous endometrial carcinoma.
Case report: A 60-year post-menopausal female presented with post-menopausal bleeding. Subsequently, she underwent a hysterectomy, which showed atrophic and cystic endometrium with extensive adenomyosis and atypical endometrial glands, which are diffusely P53 positive with intervening negative benign and focally positive dysplastic endometrial glands. A final diagnosis of serous endometrial carcinoma arising from adenomyosis was rendered. In a table format, previously reported serous endometrial carcinoma Arising cases from adenomyosis using PubMed search had been described.
Conclusion: Serous endometrial carcinoma arising from adenomyosis (<20 cases reported) and has a slightly more dismal prognosis than those deriving from the endometrial cavity. Hence, this case report highlights the occurrence, rarity, and importance of such an entity.
2. Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983; 15: 10–17.
3. Ferenczy A Pathophysiology of adenomyosis. Hum Reprod Update 1998; 4: 312–22.
4. Vercellini P, Vigano P, Somigliana E et al. Adenomyosis: epidemiological factors. Best Pract Res Clin Obstet Gynaecol 2006; 20: 465–77.
5. Colman HI, Rosenthal AH. Carcinoma is developing in areas of adenomyosis. Obstet Gynecol 1959; 14: 342–8.
6. Couto D, Mota F, Silva T, et al. adenocarcinoma arising in adenomyosis: report of an unusual case. Acta Obstet Gynecol Scand 2004; 83: 406–8.
7. Izadi-Mood N, Samadi N, Sarmadi S, et al. papillary serous carcinoma arising from adenomyosis presenting as intramural leiomyoma. Arch Iran Med 2007; 10: 258–60.
8. Kucera E, Hejda V, Dankovcik R, et al. Malignant changes in adenomyosis in patients with endometrioid adenocarcinoma. Eur J Gynaecol Oncol 2011; 32: 182–4.
9. Griffin M, Parai S, Ghatage P, et al. Papillary serous carcinoma of the uterus arising in an adenomyoma.
Acta Cytol 1996; 40: 849–50.
10. Koshiyama M, Suzuki A, Ozawa M, et al. Adenocarcinomas arising from uterine adenomyosis: a report of four cases. Int J Gynecol Pathol 2002; 21: 239–45.
11. Abushahin N, Zhang T, Chiang S, Zhang X, Hatch K, Zheng W. Serous endometrial intraepithelial carcinoma arising in adenomyosis: a report of 5 cases. Int
J Gynecol Pathol. 2011; 30: 271–81.
12. Lu B, Chen Q, Zhang X, Cheng L. Serous carcinoma arising from uterine adenomyosis/ adenomyotic cyst of the cervical stump: a report of 3 cases. Diagn Pathol 2016; 11: 46.
13. Machida H, Maeda M, Cahoon SS, Scannell CA, Garcia-Sayre J, Roman LD, et al. Endometrial cancer arising in adenomyosis versus endometrial cancer coexisting with adenomyosis: are these two different entities? Arch Gynecol Obstet 2017; 295: 1459-68.
14. Liu C, Chang W, Liu W, Wang P. Serous carcinoma arising from adenomyosis. Taiwanese Journal of Obstetrics and Gynecology. 2017; 56: 706-7.
| Files | ||
| Issue | Vol 15, No 2 (June 2021) | |
| Section | Case Reports | |
| DOI | https://doi.org/10.18502/jfrh.v15i2.6454 | |
| Keywords | ||
| Endometrial Neoplasms Adenomyosis Menopause Carcinoma in Situ Endometrium Carcinoma | ||
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