Comparison of Maternal and Umbilical Cord Blood Selenium Levels in Low and Normal Birth Weight Neonates
Abstract
Objective:To compare the maternal and umbilical cord serum selenium concentrations in Low and normal birth weight neonates.
Materials and methods:A case-control study was carried out in Vali-Asr and Akbarabadi Hospitals (Jan. to Dec. 2013). Two groups; case group; 91 mothers who delivered a low birth weight (LBW) neonate and control group; 86 subjects who delivered a normal birth weight neonate were selected. Immediately after birth, 5 ml of maternal blood and umbilical cord blood were collected, and sent to laboratory to assay Se concentrations. To compare both groups' blood Se concentration, data were analyzed in SPSS 16.0.
Results:Eighty six (48.6%) mothers with normal birth weight neonates and 91 (51.4%) mothers with low birth weight infants entered the study. Mean maternal mothers' age and mean maternal blood Se were 28.55+5.90 years and 79.3756+26.46915. A significant association was seen between maternal blood and cord blood Se level in control and case group (P value<0.0001, r = 0.69) and
(P value<0.001, r = 0.79). On the other hand no differences were seen between 2 groups' maternal blood Se level (P Value = 0.65). Umbilical Cord blood Se concentration was not also different between case and control group (P value = 0.46).
Conclusion:We found that maternal and umbilical cord blood Se concentrations were not different in low and adequate birth weight infants, however; umbilical cord Se concentrations were positively correlated with maternal blood Se concentrations.
Al-Saleh I, Al-Rouqi R, Obsum CA, Shinwari N, Mashhour A, Billedo G, et al. Interaction between cadmium (Cd), selenium (Se) and oxidative stress biomarkers in healthy mothers and its impact on birth anthropometric measures.Int J Hyg Environ Health 2015; 218:66-90.
Makhoul IR, Sammour RN, Diamond E, Shohat I, Tamir A, Shamir R. Selenium concentrations in maternal and umbilical cord blood at 24-42 weeks of gestation: basis for optimization of selenium supplementation to premature infants. Clin Nutr 2004;23:373-81.
Lorenzo Alonso MJ, Bermejo Barrera A, Cocho de Juan JA, Fraga Bermudez JM, Bermejo Barrera P. Selenium levels in related biological samples: human placenta, maternal and umbilical cord blood, hair and nails. J Trace Elem Med Biol 2005;19:49-54.
Tsuzuki S, Morimoto N, Hosokawa S, Matsushita T. Associations of maternal and neonatal serum trace element concentrations with neonatal birth weight. PloS one. 2013;8.
DPhil MP, Wijnen H, Vader H, Kooistra L, Pop V. Maternal selenium status during early gestation and risk for preterm birth. CMAJ 2011; 183:549-55.
Peirovifar A, Gharehbaghi MM, Abdulmohammad- Zadeh H, Sadegi GH, Jouyban A. Serum selenium levels of the very low birth weight premature newborn infants with bronchopulmonary dysplasia. J Trace Elem Med Biol 2013;27:317-21.
Bogden JD, Kemp FW, Chen X, Stagnaro-Green A, Stein TP, Scholl TO. Low-normal serum selenium early in human pregnancy predicts lower birth weight. Nutrition Research 2006;26:497-502.
Iranpour R, Zandian A, Mohammadizadeh M, Mohammadzadeh A, Balali-Mood M, Hajiheydari M. Comparison of maternal and umbilical cord blood selenium levels in term and preterm infants. Zhongguo Dang Dai Er Ke Za Zhi 2009;11:513-6.
Mohammadzadeh A, Farhat AS, Valaee L, Khadem N, Khajedaluee M, Parizadeh S.M.R. Maternal serum selenium and low birth weight neonates. Journal of Neonatal – Perinatal Medicine 2009; 2: 103-7.
Safaralizadeh R, Sirjani M, Pourpak Z, Kardar G, Teimourian S, Shams SH, et al. Serum selenium concentration in healthy children living in Tehran. Biofactors 2007; 31: 127-231.
Dobrzynski W, Trafikowska U, Trafikowska A, Pilecki A, Szymanski W, Zachara BA. Decreased selenium concentration in maternal and cord blood in preterm compared with term delivery. Analyst 1998 ;123:93-7.
Sun H, Chen W, Wang D, Jin Y, Chen X, Xu Y. The effects of prenatal exposure to low-level cadmium, lead and selenium on birth outcomes. Chemosphere 2014;108:33-9.
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Issue | Vol 9, No 3 (September 2015) | |
Section | Original Articles | |
Keywords | ||
Selenium level maternal blood umbilical cord blood LBW neonates Normal birth weight neonates |
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