Original Articles

Neurodevelopmental Status of Infants Conceived Assisted Reproductive Techniques in Royan Institute

Abstract

Objective: There is a large amount of information published about ART infants worldwide but apparently the similar data did not published by Iranian ART centers till now. This study is a comparative study for developmental assessment of these infants.
Materials and methods: In one case- control study 400 ART ' infants have been compared with 420 NC ' infants. Their developments have been assessed two times with test of Denver II until 9 months old.
All of them were citizen of Tehran and assessed in one center. They have been adjusted for duration of pregnancy and delivery result. Chi- Square test and Wilcoxon Singned Ranks test were used for analysis of data.
Results: From 400 infants of ART, 31/3% was preterm and 42/8% were multi fetal pregnancy, which were higher than NC. There was not significant difference in development of infants of ART and NC in different methods of ART in two times assessment (without concerning premature and multi fetal pregnancy) (P>0/05). There was not significant difference between development of term and single fetal pregnancy of ART and NC in first and second time of assessment of development (p values were 0/7 and 0/4 respectively).
Conclusion: We concluded that there is not any difference in development of term and single fetal pregnancy in infants of ART and NC until 9 months old.

Adamson GD, de Mouzon J, Lancaster P, Nygren KG, Sullivan E, et al. World collaborative report on in vitro fertilization, 2000. Fertil Steril 2006; 85:1586-622.

Steptoe PC, Edwards RG. Birth after the reimplantation of a human embryo. Lancet 1978; 2: 366.

Basatemur E, Sutcliffe A. Follow-up of children born after ART. Placenta 2008; 29:S135-40.

Fauser Bc , Devroey P , Macklon NS . Multiple birth resulting from ovarian stimulation for subfertility treatment. Lancet 2005; 365: 1807-16.

Bergh T, Ericson A, Hillensjö T, Nygren KG, Wennerholm UB. Deliveries and children born after invitro fertilisation in Sweden 1982-95: a etrospective cohort study. Lancet 1999 ;354:1579-85.

Koivurova S, Hartikainen AL, Gissler M, Hemminki E, Sovio U, Järvelin MR. Neonatal outcome and congenital malformations in children born after in-vitro fertilization. Hum Reprod 2002 ;17:1391-8.

Katalinic A, Rösch C, Ludwig M; German ICSI Follow- Up Study Group. Pregnancy course and outcome after intracytoplasmic sperm injection: a controlled, prospective cohort study. Fertil Steril 2004 ;81:1604-16.

Gray RH, Wu LY. Sub fertility and risk of spontaneous abortion. American Journal of Public Health 2000; 90:1452-4.

Joffe M, Li Z. Association of time to pregnancy and the outcome of pregnancy. Fertil Steril 1994 ;62:71-5.

Lambert RD. Safety issues in assisted reproductive technology: etiology of health problems in singleton ART babies. Human Reproduction Journal 2003; 18:1987-91.

Alastair G Sutcliffe. Health and welfare of ART children. 1 st ed. UK: Information health care; 2006; 87-105.

Koivurova S, Hartikainen AL, Sovio U, Gissler M, Hemminki E, Järvelin MR. Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF. Hum Reprod 2003 ;18:2328-36.

Lidegaard O, Pinborg A, Andersen AN. Imprinting disease and IVF Danish National IVF cohort study. Human Reproduction Journal 2005; 20:950-4

Wennerholm UB, Albertsson-Wikland K, Bergh C, Hamberger L, Niklasson A, Nilsson L, et al. Postnatal growth and health in children born after cryopreservation as embryos. Lancet 1998;351:1085-90.

Sutcliffe AG, D souza SW, Cadman J, Richards B, McKinlay IA, Lieberman B. Outcome in children from cryopreserved embryos. Archives of Disease in Children 1995; 72:290-3

Sutcliffe AG, Taylor B, Li J, Thornton S, Grudzinskas JG, Lieberman BA. Children born after intracytoplasmic sperm injection: population control study. BMJ 1999; 318: 704-5.

Sutcliffe AG, Taylor B, Saunders K, Thornton S, Lieberman BA, Grudzinskas JG. Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection: a UK case-control study. Lancet 2001; 357: 2080-4.

Sutcliffe AG, Saunders K, McLachlan R, Taylor B, Edwards P, Grudzinskas G, et al. A retrospective casecontrol study of developmental and other outcomes in a cohort of Australian children conceived by intracytoplasmic sperm injection compared with a similar group in the United Kingdom. Fertil Steril 2003; 79: 512-6.

Ludwig AK, Sutcliffe AG, Diedrich K, Ludwig M. Post-neonatal health and development of children born after assisted reproduction: a systematic review of controlled studies. Eur J Obstet Gynecol Reprod Biol 2006 ;127: 3-25.

Wagenaar K, Huisman J, Cohen-Kettenis PT, Delemarre-van de Waal HA. An overview of studies on early development, cognition, and psychosocial wellbeing in children born after in vitro fertilization. J Dev Behav Pediatr 2008; 29: 219-30.

Ludwig AK, Sutcliffe AG, Diedrich K, Ludwig M. Post-neonatal health and development of children born after assisted reproduction: a systematic review of controlled studies. Eur J Obstet Gynecol Reprod Biol 2006 ;127:3-25.

Izat Y, Goldbeck L. The development of children from assisted reproduction - a review of the literature. Prax Kinderpsychol Kinderpsychiatr 2008; 57:264-81.

Ito A, Honma Y, Inamori E, Yada Y, Momoi MY, Nakamura Y. Developmental outcome of very low birth weight twins conceived by assisted reproduction techniques. J Perinatol 2006 ;26:130-3.

Gibson FL, Ungerer JA, Leslie GI, Saunders DM, Tennant CC. Development, behaviour and temperament: a prospective study of infants conceived through in-vitro fertilization. Hum Reprod 1998 ;13:1727-32.

Ponjaert-Kristoffersen I, Tjus T, Nekkebroeck J, Squires J, Verté D, Heimann M, et al. Psychological follow-up study of 5-year-old ICSI children. Hum Reprod 2004;19: 2791-7.

Zhu JL, Basso O, Obel C, Hvidtjørn D, Olsen J. Infertility, infertility treatment and psychomotor development: the Danish National Birth Cohort. Paediatr Perinat Epidemiol 2009 ;23:98-106.

Bowen JR, Gibson FL, Leslie GI, Saunders DM. Medical and developmental outcome at 1 year forchildren conceived by intracytoplasmic sperm injection. Lancet.1998; 351: 1529-34.

Sutcliffe AG. Health and welfare of ART children. 1st ed.UK: In formation health care; 2006:1-4.

Human fertilization and embryology authority. Seventh annual human fertilization and embryology authority report. London: HFEA, 1998.

Cohen J. Mayaux MJ. Guihard Moscato ML. Pregnancy outcomes after invitro fertilization. A collaborative study on 2345 pregnancies. Ann NY Acad Science: 1988; 541:1-6.

Papaligoura Z, Panopoulou-Maratou O, Solman M, Arvaniti K, Sarafidou J.Cognitive development of 12 month old Greek infants conceived after ICSI and the effects of the method on their parents. Hum Reprod 2004 ;19: 1488-93.

Leslie GI, Gibson FL, McMahon C, Cohen J, Saunders DM, Tennant C. Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age. Hum Reprod 2003 ;18: 2067-72.

Pruksananonda C. Growth and development of children conceived by intracytoplasmic sperm injection at King Chulalongkorn Memorial Hospital. Journal Medical Association Thailand 2001; 84: S76-85.

Files
IssueVol 5, No 3 (September 2011) QRcode
SectionOriginal Articles
Keywords
Assisted Reproductive Techniques neurodevelopmental state Infants Denr II

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Kermani RMK, Nedaeifard L, Nateghi M, Fazeli A. Neurodevelopmental Status of Infants Conceived Assisted Reproductive Techniques in Royan Institute. J Family Reprod Health. 2011;5(3):79-83.