Level of Bisphenol A in Follicular Fluid and Serum and Oocyte Morphology in Patients Undergoing IVF Treatment

  • Seyedeh Mahsa Poormoosavi Research and Clinical Center for Infertility, Department of Histology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran
  • Mohammad Amin Behmanesh Department of Histology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran
  • Sima Janati Department of Obstetrics and Gynecology, School of Medicine, Research and Clinical Center for Infertility, Dezful University of Medical Sciences, Dezful, Iran
  • Hosein Najafzadehvarzi Department of pharmacology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Bisphenol A, Follicular Fluid, IVF, Oocyte Morphology


Objective: To assess the correlation between the levels of BPA in the serum and follicular fluid (FF) using oocyte morphology.Materials and methods: In this cross-sectional research, oocyte, FF, and serum samples were obtained from a sample population consisting of 90 women undergone in vitro fertilization in Ganjavian Hospital in Dezful, Iran during October 2017-March 2018. The ELISA kit was utilized for the measurement of the BPA levels. In addition, oocyte morphology simultaneous with inverted optical microscopy.Results: Follicular fluid BPA levels had no significant effect on MII oocytes (p ≥ 0.05). However, the mean levels of degenerated oocytes and germinal vesicle (GV) were significantly higher in the women with high BPA levels in the FF (p ≤ 0.05). Moreover, the mean counts of MII oocytes and oocytes were significantly higher in the women with serum BPA levels of ≤ 50 ng/ml (p ≤ 0.05), while the mean count of GV oocytes was significantly higher in the women with serum BPA levels of ≥ 150 ng/ml (p ≤ 0.05).Conclusion: According to the results, higher FF BPA levels were associated with the higher counts of GVs and oocytes, while oocytes with higher maturity can be achieved in lower levels of BPA in the serum of patients.


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How to Cite
Poormoosavi SM, Behmanesh M, Janati S, Najafzadehvarzi H. Level of Bisphenol A in Follicular Fluid and Serum and Oocyte Morphology in Patients Undergoing IVF Treatment. J Fam Reprod Health. 13(3):154-159.
Original Articles