A Survey of Venous Thromboembolism (VTE) Prophylaxis in Obstetrics Patients in Iran

  • Majid Mokhtari Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Imam Hosein Hospital, Tehran, Iran
  • Khadijeh Nasri Department of Obstetrics and Gynecology, Arak University of Medical Sciences, Arak, Iran
  • Fatemeh Tara Department of Obstetrics and Gynecology, Mashhad University of Medical Sciences, Ommol Banin Teaching Hospital, Mashhad, Iran
  • Elahe Zarean Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Alzahra Teaching Hospital, Isfahan, Iran
  • Sedigheh Hantoushzadeh Maternal-Fetal Medicine Research Center, Tehran University of Medical Sciences, Imam Khomeini Teaching Hospital, Tehran, Iran
  • Mehrnaz Radmehr Department of Obstetrics and Gynecology, Milad Hospital, Tehran, Iran
  • Maryam Kashanian Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Akbarabadi Teaching Hospital, Tehran, Iran
Venous Thrombo-embolism, Obstetric Population, Deep Venous Thrombosis, VTE Prophylaxis, Pulmonary Embolism


Objective: The purpose of the present study was a survey of venous thromboembolism (VTE) prophylaxis in obstetrics patients in Iran.Materials and methods: A national, multicenter, non-interventional, prospective study was performed on 1000 women at 11 different parts of Iran. Primary outcome was to assess the situation of VTE prophylaxis in pregnant and postpartum women and the secondary outcome was risk stratification in obstetrics patients and to evaluate the guideline adherence in physician’s practice of VTE prophylaxis.Results: 1,036 women entered the final analysis. The three main VTE risk factors before hospitalization were BMI > 30 kg/m2, history of oral contraceptive (OCP) use, and the age over 35.VTE risk factors upon enrollment were detected in 780 (75.28%) patients. 219 women (28.07%) were deemed eligible for drug prophylaxis, however, only 37 women (17%) received it. A total of 113 (10.9%) patients received VTE prophylaxis, of which 76 (67.25%) women had no clear indications. Concordance between theory and practice was detected with a Cohen’s Kappa coefficient to be 0.74 (p < 0.001), which fell within “good agreement”. Multivariate analysis for association between VTE prophylaxis and VTE risk factors showed that history of VTE [OR = 9.06 (CI 95% 1.16 – 70.8) p = 0.036] was the most frequent risk factor for receiving VTE prophylaxis followed by obesity (BMI > 30 Kg/m2); [OR = 3.74 (CI 95% 1.79 – 5.69), p = <0.001], multiple pregnancy [OR= 2.81 (CI 95% 1.70 – 4.64), p = < 0.001] and age > 35 years; [OR =1.09 (CI 95% 0.82 – 1.21), p = 0.026]. Varicose Veins [OR= 0.22 (CI 95% 0.56 – 0.87), p = 0.031], PROM / PPROM [OR= 0.33 (CI 95% 0.12 – 0.91), p = 0.032] and history of using OCP [OR= 0.36 (CI 95% 0.24 – 0.53), p = < 0.001] were the most missed risk factors for receiving VTE prophylaxis respectively. Conclusion: History of VTE, obesity, multiple pregnancy and age > 35 years were the most frequent risk factors for receiving VTE prophylaxis and varicose veins, PROM / PPROM and history of using OCP were the most missed risk factors for receiving VTE prophylaxis.


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How to Cite
Mokhtari M, Nasri K, Tara F, Zarean E, Hantoushzadeh S, Radmehr M, Kashanian M. A Survey of Venous Thromboembolism (VTE) Prophylaxis in Obstetrics Patients in Iran. J Fam Reprod Health. 13(1):21-25.
Original Articles