Original Articles

The Correlation of Prenatal Zinc Concentration and Deficiency with Anthropometric Factors

Abstract

Objective: To determine the status of serum zinc in pregnant women in different gestational ages and correlation with socio-demographic and anthropometric factors in Iranian women referring to prenatal care public health clinics
.Materials and methods: We analyzed the zinc concentrations in plasma samples obtained at different gestational ages from 961 women and recorded BMI at the first trimester in pregnant women who were screened for a trial designed to evaluate the zinc concentration. Subjects were from different socio economical backgrounds and attended public health clinics for their prenatal care. All analyses were performed by SPSS (version 16). P values < 0.05 were considered significant.
Results:
The results showed that after plasma zinc concentrations were adjusted with Parity, weight (early pregnancy), BMI (at early pregnancy), age and educational statues. Plasma zinc deficiency declined as gestational age progressed, however it was not significant. There was no significant correlation between zinc concentration, anthropometric, method of contraception and socio factors. However, there were significant relation between parity (p = 0.007) and weight at early pregnancy (p= 0.039) with serum zinc levels.
Conclusion:
We conclude that plasma zinc concentrations decreased during the late first trimester to the early third trimester and with parity. These findings may indicate that the deficient levels of zinc in the latter third of pregnancy suggest a tendency for insufficient maternal nutrition. However larger studies are required to support this finding.

Shah D, Sachdev HP. Effect of gestational zinc deficiency on pregnancy outcomes: Summary of observation studies and zinc supplementation trials. Br J Nutr 2001; 85(Suppl 2):101–8.

World Health Organization. Trace elements in human nutrition and health [internet] . Geneva; Available from:http://whqlibdoc.who.int/publications/1996/92415 61734_eng_fulltext.pdf

Shah D, Sachdev HP Cetin I, Berti C, Calabrese S. Role of micronutrients in the periconceptional period; Human Reproduction Update 2010; 16: 80–95.

Swanson CA, King JC. Zinc and pregnancy outcome. Am J Clin Nutr 1987;46:763–71.

Apgar J . Zinc and reproduction: an update. J Nutr Biochem 1992; 3: 266–78.

Tamura T, Goldenberg RL. Zinc nutriture and pregnancy outcome. Nutr Res1996;16: 139–81.

Meadows NJ, Ruse W, Smith MF, et al. Zinc and small babies. Lancet 1981; 2: 1135–37.

Simmer K, Punchard NA, Murphy G, Thompson RPH. Prostaglandin production and zinc depletion in human pregnancy. Pediatr Res 1985;19: 697–700.

Tamura T, Weekes EW, Birch R, Franklin JC, Cosper P, Davis RO, et al. Relationship between amniotic fluid and maternal blood nutrient levels. J Perinat Med 1994; 22: 227–34.

Scholl TO, Hediger ML, Schall JI, Fisher RL, Khoo CS. Low zinc intake during pregnancy: its association with preterm and verypreterm delivery. Am J Epidemiol. 1993 137: 1115–24.

Shah D, Sachdev HP . Effect of gestational zinc deficiency on pregnancy outcomes: summary of observation studies and zinc supplementation trials. Br J Nutr 2001; 85 Suppl 2:S101-8.

Burits CA, Ashwood ED . Tietz text book of clinical chemistry.2nd ed, 1994.

Prasad AS. Zinc in human health. J Trace Elem 1998; 11: 63-87.

Jameson S. Zinc status and pregnancy outcome in humans. First Edition, Alan R.Liss, 1982. 39-52.

Sanders WB, Sandstead HH . Zinc deficiency, A public health problem? Am J Dischild, 1991; 145: 853-59.

Prasad AS. Syndrome of iron deficiency, anemia, hepatic, hypogonadism, dwarfism and geophagia. Am J Med 1961; 31: 532-46.

Osendarp SJ, Van Raaij JM, Darmstadt GL, Baqui AH, Hautvast JG, Fuchs GJ. Zinc supplementation during pregnancy and effects on growth and morbidity in low birth weight infants a randomized placebo controlled trial. Lancet 2001; 357: 1080-85.

Norrozi M, Borna S, Hanachi P, Faghyhzadeh S, Haghollahi F, Golkho Sh. Evaluation of Zinc Supplementation Effect on Fetal Outcomes in Pregnant Women with Lower‐than‐Median Serum Zinc Concentration. Journal of Family and Reproductive Health 2012; 6: 85-9.

Hanachi P, Golkho S, Norrozi M. The association of serum Zinc levels with socio demographic factors, red and white blood cells count in pregnant women. Journal Applied Science 2008; 8: 4679-83.

Abebe Y, Bogale A, Hambidge KM, Stoecker BJ, Arbide I, Teshome A, Krebs NF, Westcott JE, Bailey KB, Gibson RS. Inadequate intakes of dietary zinc among pregnant women from subsistence households in Sidama, Southern Ethiopia. Public Health Nutr2008; 11:379–86.

Pezzullo JC. Proportion Difference Power/Sample Size Calculation. http://statpages.org/proppowr.html

Hunt IF, Murphy NJ, Cleaver AE, Faraji B, Swendseid ME, Coulson AH, et al. Zinc supplementation during pregnancy: zinc concentration of serum and hair from low-income women of Mexican descent. Am J Clin Nutr 1985; 37: 572–82.

Tuttle S, Aggett PJ, Campbell D, MacGillivray I. Zinc and copper nutrition in human pregnancy: a longitudinal study in normal primigravidae and in primigravidae at risk of delivering a growth retarded baby. Am J Clin Nutr 1985; 41: 1032–41.

Andersen AMN, Mortensen LH. Socioeconomic inequality in birth outcomes: what do the indicators tell us, and where do we find the data. CMAJ 2006; 174: 1429–30

Ugwuja EI, Ugwu NC. Helicobacter pylori in uninvestigated dyspepsia in primary health cares in Abakaliki, Nigeria. Online J Health Allied Sci 2007; 1: 4-10.

Salimi S, M Yaghmaei M, HR Joshaghani HR, AR Mansourian AR. Study of Zinc Deficiency in Pregnant Women. Iranian J Publ Health 2004;33: 15-18.

King JC. Determinants of maternal zinc status during pregnancy, Am J Clin Nutr 2000; 71(suppl), 1334S.

Gebremedhin S, Enquselassie F, and Umeta M. Prevalence of prenatal zinc deficiency and its association with socio-demographic, dietary and health care related factors in Rural Sidama, Southern Ethiopia: A crosssectional study. BMC Public Health 2011; 11, 898.

Goldenberg RL, Tamura T, Neggers Y, Copper RL, Johnston KE, Dubard MB and et al. The effect of zinc supplementation on pregnancy outcome. JAMA 1995; 9: 463-68.

Files
IssueVol 8, No 1 (March 2014) QRcode
SectionOriginal Articles
Keywords
Anthropometry Parity Socio-Demographic Factors Zinc

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Hanachi P, Norrozi M, Moosavi RM. The Correlation of Prenatal Zinc Concentration and Deficiency with Anthropometric Factors. J Family Reprod Health. 2014;8(1):21-26.