Journal of Family and Reproductive Health 2015. 9(3):113-117.

The Relationship between Maternal Vitamin D Deficiency and Low Birth Weight Neonates
Nasrin Khalessi, Majid Kalani, Mehdi Araghi, Zahra Farahani

Abstract


Objective:Maternal hypovitaminosis D may impair fetal growth and cause adverse pregnancy outcomes including intrauterine growth restriction and neonatal low birth weight. The aim of this study is to evaluate the relationship between maternal vitamin D status and neonate’s birth weight.
Materials and methods:A cross-sectional, descriptive analytical study was carried out in the nursery ward of 2 hospitals (Tehran-Iran) during one year (January 2011- January 2012). One hundred and two neonates were categorized into two groups, neonates with birth weight< 2500 gr (n=52) and neonates with birth weight>2500 gr (n=50). Data regarding medical history, physical examination and anthropometric measurements of neonates were noted in a questionnaire. Birth time blood samples of their mothers were analyzed for serum 25-(OH)-vitamin D by ELISA method. Maternal vitamin D status was compared in two groups.
Results:Mean maternal vitamin D (vit D) level was 31.46 nmol/L. Forty eight percent of mothers had vitamin D deficiency, 27.5% had vit D insufficiency and 24.5% were normal. Mean maternal vitamin D level of LBW neonates was lower than other group; 25.05 vs. 38.13 (p= 0.001). All mothers of neonates with head circumference ≤ 33 cm also had vitamin D deficiency (p= 0.007).
Conclusion:Maternal Vitamin Ddeficiency may increase the risk of low birth weight neonate and modifying maternal nutrition behavior and their vit D level could be beneficial on pregnancy outcome.


Keywords


Infant; Low birth weight; vitamin D Deficiency

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References


Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant. 8th ed: Mosby, 2005.

Thorne-Lyman A, Fawzi W. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes:A systematic review and meta-analysis.Pediatric and Perinatal Epidemiology 2012; 26:75-90.

Karim S, Nusrat U, Aziz S. Vitamin D deficiency in pregnant women and their newborns as seen at a tertiary – care center in Karachi, Pakistan. Int J Gynaecol Obstet 2011; 112:59-62.

Ford J. preconception factors and SGA babies;papilloma virus, omega 3 and fat soluble vitamin deficiencies. Early Human Development 2011; 87: 785-9.

Sioen I, Mouratidou T, Kaufman JM, Bammann K, Michels N, Pigeot I, et al. Determinants of vitamin D status in young children: results from the Belgianarm of the IDEFICS (Identification and Prevention of Dietary- and Lifestyle-induced Health Effects in Children and Infants) Study. Public Health Nutr 2012;15:1093-9.

Kazemi A, Sharifi F, Jafari N, Mousavinasab N. High prevalence of vitamin D deficiency among pregnant women and their newborns in an Iranian population. J Womens Health (Larchmt) 2009;18: 835-9.

Hossain N, Paidas MJ. High prevalence of vitamin D deficiency in Pakistani mothers and their newborns. International Journal of Gynecology and Obstetrics 2011; 112: 229–33.

Patel M , Beg m, Akhtar N, Ahmad J, Farooqui Kh.Serum calcium, vitamin D and parathyroid hormone relationship among diabetic And nondiabetic pregnant women and their neonates. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2010; 4: 204–9.

Bodnar L M, Catov J M, Zmuda J M, Cooper M E.,Parrott MS, Roberts J M. et al. Maternal serum 25- hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women. J Nutr 2010; 140 : 999-1006.

Lee JM, Smith JR, Philipp BL, Chen TC, Mathieu J, Holick MF. Vitamin D deficiency in a healthy group of mothers and newborn infants. Clin Pediatr (Phila) 2007; 46: 42-4.

Fernández-Alonso AM, Dionis-Sánchez EC, Chedraui P, González-Salmerón MD, Pérez-López FR; Spanish Vitamin D and Women's Health Research Group. Firsttrimester maternal serum 25-hydroxyvitamin D₃ status and pregnancy outcome.Int J Gynaecol Obstet 2012;116: 6-9.

Leffelaar ER, Vrijkotte TG, van Eijsden M. Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: results of the multi-ethnic Amsterdam Born Children and their Development cohort. Br J Nutr 2010; 104: 108-17.

Shin JS, Choi MY, Longtine MS, Nelson DM. Vitamin D effects on pregnancy and the placenta. Placenta 2010;31:1027-34.

Burris HH, Rifas-Shiman SL, Camargo CA Jr, Litonjua AA, Huh SY, Rich-Edwards JW, et al. Plasma 25- hydroxyvitamin D during pregnancy and small-forgestational age in black and white infants. Ann Epidemiol 2012;22:581-6.

Aghajafari F, Nagulesapillai T, Ronksley PE, Tough SC, O'Beirne M, Rabi DM. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. BMJ 2013; 346:f1169.

Hashemipour S, Ziaee A, Javadi A, Movahed F, Elmizadeh K, Javadi EH, et al. Effect of treatment of vitamin D deficiency and insufficiency during pregnancy on fetal growth indices and maternal weight gain: a randomized clinical trial. Eur J Obstet Gynecol Reprod Biol 2014;172:15-9.

Dror D, King J, Durand D, Allen L. Association of Modifiable and Nonmodifiable Factors with Vitamin D Status in Pregnant Women and Neonates in Oakland, CA. J Am Diet Assoc 2011; 111: 111-6.

Scholl TO, Chen X. Vitamin D intake during pregnancy: association with maternal characteristics and infant birth weight. Early Hum Dev 2009;85:231-4.

Bodnar LM, Simhan HN, Powers RW, Frank MP, Cooperstein E, Roberts JM. High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates.J Nutr 2007;137: 447-52.


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