G-CSF Intrauterine for Thin Endometrium, and Pregnancy Outcome

  • Ensieh Tehraninejad Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Fateme Davari Tanha Department of Reproductive Endocrinology, Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Ebrahim Asadi Department of Reproductive Biology, Women’s Hospital, Tehran University of MedicalSciences, Tehran, Iran
  • Koorosh Kamali Department of Public Health, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran
  • Elham Aziminikoo Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Elahe Rezayof Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran
Keywords: ART cycle, Thin endometrium, G-CSF

Abstract

Objective:To evaluate effects ofG-CSF on a cancelled ART cycle due to thin endometrium.Materials and methods:In a nonrandomized clinical trial from January 2011 to January 2013 in two tertiary university based hospitals fifteen patients undergoing embryo transfer and with the history of cycle cancellation due to thin endometrium were studied. Intrauterine infusion of G-CSF was done on the day of oocyte pick-up or 5 days before embryo transfer. The primary outcome to be measured was an endometrium thickened to at least 6 mm and the secondary outcome was clinical pregnancy rate and consequently take-home baby. All previous cycles were considered as control for each patient.Results:The G-CSF was infused at the day of oocyte retrieval or 5 days before embryo transfer. The endometrial thickness reached from3.593±0.251 mm to 7.120±0.84 mm. The mean age, gravidity, parity, and FSH were 35.13± 9.531 years,3, 1 and32.78± 31.10 mIU/ml, respectively. The clinical pregnancy rate was 20%, and there was one missed abortion, a mother death at 34 weeks, and a preterm labor at 30 weeks due to PROM.Conclusion:G-CSF may increase endometrial thickness in the small group of patients who had no choice except cycle cancellation or surrogacy.

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Published
2015-10-06
How to Cite
1.
Tehraninejad E, Davari Tanha F, Asadi E, Kamali K, Aziminikoo E, Rezayof E. G-CSF Intrauterine for Thin Endometrium, and Pregnancy Outcome. J Fam Reprod Health. 9(3):107-112.
Section
Original Articles