The The Effects of Carum Carvi (Bunium Persicum Boiss) on Early Return of Bowel Motility After Caesarean Section: Double-Blind, Randomized, Placebo-Controlled Trial

  • Seyde Sedighe Yousefi Asistant Professor, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran AND Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  • Omid Sadeghpour The Research Institute for Islamic & Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Zeinab Hamzehgardeshi Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran AND Sexual and Reproductive Research Centre, Mazandaran University of Medical Sciences, Sari, Iran
  • Farnaz Sohrabvand Department of Obstetrics, Gynecology & Infertility, School of Medicine, Tehran University of Medicine Sciences, Tehran, Iran
Keywords: Ileus, Caesarean Section, Bunium Persicum Boiss, Traditional Persian Medicine


Objective: To investigate the effect of the Carumcarvi (BuniumpersicumBoiss) plant, a gas solvent, on resumption of bowel motility after caesarean section.Materials and methods: A randomized controlled trial was done on a group of 98 women undergoing elective caesarean section under general anesthesia in a university hospital. Patients in the intervention group (Group A) drank 10 ml of a syrup containing 8 g of BuniumpersicumBoiss in 20 ml of syrup 6 to 7 hours after surgery. The control group (Group B) comprised 10 patients who drank 10 ml of placebo syrup 6 to 7 hours after surgery. Demographic characteristics, time to first hearing of normal intestinal sounds, time to first flatus, time to first bowel movement, and length of hospital stay were compared between the two groups.Results: Compared with the control group, the intervention group had a significantly shorter mean time to hearing the first intestinal sounds (10.66 ± 2.38 vs. 19.54 ± 3.85 h), mean time to first flatus (13.91 ± 3.73 vs. 24.82 ± 5.83 h), mean time to first bowel movement (19.31 ± 4.63 vs. 30.70 ± 10.21 h), and mean length of hospitalization (31.70 ± 7.70 vs. 49.20 ± 10.16 h) (p < 0.05). No patients developed serious side effects associated with consumption of the syrup. Conclusion: The use of a gas solvent such as BuniumpersicumBoiss after caesarean section can speed the resumption of postoperative bowel motility.


1. Rashidian A, Karimi-Shahanjarini A, Khosravi A, Elahi E, Beheshtian M, Shakibazadeh E, et al. Iran's Multiple Indicator Demographic and Health Survey - 2010: Study Protocol. Int J Prev Med 2014; 5:632-42.
2. Williams obstetrics.Cunningham, F Gary; Williams, J Whitridge (John Whitridge), 1866-1931. 23rd ed. /[edited by] F. Gary Cunningham ... [et al.]. New York : McGraw-Hill, Medical,c2010.
3. Yaghmaei M, Kalati FA, Mokhtari M, Behzadian A. Comparison of oral intake profiles at 2 and 8 hours following cesarean section under spinal anesthesia. Zahedan Journal of Research Medical Sciences 2010; 11:43-51.
4. Hirayama I, Suzuki M, Asao T, Kuwano H. Gum-chewing stimulates bowel motility after surgery for colorectal cancer. Hepatogastroenterology 2006; 53:206-8.
5. Johnson MD, Walsh RM. Current therapies to shorten postoperative ileus. Cleve Clin J Med 2009; 76:641-8.
6. Nimarta N, Vir S, Gupta SR. Effectivness of chewing gum on bowel motility among the patients who have undergone Abdominal Surgery. NMRJ. 2013; 9:108-17.
7. Delaney CP. Clinical perspective on postoperative ileus and the effect ofopiates. Neurogastroenterol Motil 2004;16:61-6.
8. Rychter J, Clavé P. Intestinal inflammation in postoperative ileus:pathogenesis and therapeutic targets. Gut 2013; 62:1534-5.
9. Lubbers T, Buurman W, Luyer M. Controlling postoperative ileus by vagal activation. World Journal of Gastrology 2010;16: 1683-7.
10. Holte K, Kehlet H. Postoperative ileus: a preventable event. Br J Surg 2000; 87:1480-93.
11. Lewis SJ, Andersen HK, Thomas S. Early enteral nutrition within 24 h ofintestinal surgery versus later commencement of feeding: a systematic review and meta-analysis. J Gastrointest Surg 2009; 13:569-75.
12. Hausel J, Nygren J, Thorell A, Lagerkranser M, Ljungqvist O. Randomized clinical trial of the effects of oral preoperative carbohydrates on postoperative nausea and vomiting after laparoscopic cholecystectomy. Br J Surg 2005; 92:415-21.
13. Purkayastha S, Tilney HS, Darzi AW, Tekkis PP. Meta-analysis of randomized studies evaluating chewing gum to enhance postoperative recovery following colectomy. Arch Surg 2008; 143:788-93.
14. Abd-El-Maeboud KH, Ibrahim MI, Shalaby DA, Fikry MF. Gum chewing stimulates early return of bowel motility after caesarean section. BJOG 2009; 116:1334-9.
15. Pereira Gomes Morais E, Riera R, Porfírio GJ, Macedo CR, Sarmento Vasconcelos V, de Souza Pedrosa A, Torloni MR. Chewing gum for enhancing early recovery ofbowel function after caesarean section. Cochrane Database Syst Rev 2016; 10: CD011562.
16. Short V, Herbert G, Perry R, Atkinson C, Ness AR, Penfold C, et al. Chewing gum for postoperative recovery of gastrointestinal function. Cochrane Database Syst Rev 2015; 2:CD006506.
17. Lepore M, Fitzgerald JE. Gum chewing is associated with early recovery of bowel motility and shorter length of hospital stay for women after caesarean section. Evid Based Med 2015; 20:22.
18. Su'a BU, Pollock TT, Lemanu DP, MacCormick AD, Connolly AB, Hill AG. Chewing gum and postoperative ileus in adults: a systematic literature review and meta-analysis. Int J Surg 2015;14:49-55.
19. Zhu YP, Wang WJ, Zhang SL, Dai B, Ye DW. Effects of gum chewing onpostoperative bowel motility after caesarean section: a meta-analysis of randomised controlled trials. BJOG 2014; 121: 787-92.
20. Craciunas L, Sajid MS, Ahmed AS. Chewing gum in preventing postoperative ileusin women undergoing caesarean section: a systematic review and meta-analysis of randomised controlled trials. BJOG 2014; 121:793-9.
21. Hongkai Sh, Yang Y, Xiaowen T, Lijun Zh, Aiming F, Ling H. Gum Chewing Slightly Enhances Early Recovery from Postoperative Ileus after Cesarean Section: Results of a Prospective, Randomized, Controlled Trial. Amer J Perinatol 2010; 27(5): 387-391.
22. Naseri M. Traditional Iranian Medicine (Tim) and it's promotion with guidelines of world health organization. Daneshvar Medicine 2004;11:53-66.
23. Kermani NEE. Sharhe Asbaab-o- Alaamaat of. Qom:
Jalal al- Din, 2008.
24. IbnSina H. AI-Qanon fi al-Tibb[ The canon of medicine](Arabic). IS a-D, editor. Lebanon: Alamy Le- Al- Matbooat institute, 2005.
25. Nagafabadi MS, Yousefi SS, Jokar A, Askarfarashah M. Avicenna (Ibn Sina) aspect of Ileus. International journal of life sciences. 2015;9(5):1-2.
26. AghiliKhorasani SMH. Moalejate Aghili. Iran: Institute for Islamic and Complementary Medicine,Iran university of Medical Science, 2008.
27. KhosraviHamedani AA. Rahnamaye Daruhaie Tandorosti. Research Institute for Islamic & Complementary Medicine; Iran University of Medical Sciences, 2007‬.
28. Yousefi SS, Sadeghpour O, Sohrabvand F. Effectiveness of carum carvi on early return of bowel motility after caesarean section. European Journal of Experimental Biology 2014;4:258-62
29. Weinstein L, Dyne PL, Duerbeck NB. The PROEF diet--a new postoperative regimenfor oral early feeding. Am J Obstet Gynecol 1993; 168:128-31.
30. Adupa D, Wandabwa J, Kiondo P. A randomised controlled trial of earlyinitiation of oral feeding after caesarean delivery in Mulago Hospital. East Afr Med J 2003; 80:345-50.
31. Kovavisarach E, Atthakorn M. Early versus delayed oral feeding after cesarean delivery. Int J Gynaecol Obstet 2005; 90:31-4.
32. Satij B, Cohen SA. Evaluation of gum chewing on the return of bowel function in cesarean delivery patients. Obstetric & Gynecology 2006; 107:10s.
33. Teoh WH, Shah MK, Mah CL. A randomised controlled trial on beneficial effects of early feeding post-Caesarean delivery under regional anaesthesia. Singapore Med J. 2007; 48:152-7.
34. The promotion and development of traditional medicine: report of a WHO meeting. World Health Organ Tech Rep Ser 1978; 622:1-41.
35. WHO Traditional Medicine Strategy 2014-2023.
How to Cite
Yousefi SS, Sadeghpour O, Hamzehgardeshi Z, Sohrabvand F. The The Effects of Carum Carvi (Bunium Persicum Boiss) on Early Return of Bowel Motility After Caesarean Section: Double-Blind, Randomized, Placebo-Controlled Trial. J Fam Reprod Health. 13(1):35-41.
Original Articles