Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 17 2 2023 06 11 65 72 Shayesteh Behnam Anatomy Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Saeed Zavareh School of Biology, Damghan University, Damghan, Iran Mojdeh Salehnia Anatomy Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran 2022 09 14 2023 04 08 Objective: Oxidative stress affects the development of ovarian follicles during in vitro culture thus applying an antioxidant is necessary. The aim of this study was to investigate the effect of coenzyme Q10 (CoQ10) on the expression of apoptosis-related genes of mouse ovaries during in vitro culture. Materials and methods: The immature mouse ovaries were cultured in the presence of 50 μM CoQ10 for 7 days. Histological examinations were performed and the 17 beta-estradiol concentration was measured on the seventh day of culture. The relative expression of Caspase 3, Bax, Bad, and Bcl 2 genes were investigated by real-time RT-PCR. Results: The rates of normal follicles in the presence of CoQ10 was significantly increased compared to the control group. Also, in CoQ10-trated group a significant increase in the level of 17 beta-estradiol was seen compared to the control group. The mRNA expression of anti-apoptotic gene Bcl2 was significantly increased while the expression of pro-apoptotic genes (Caspase3, Bax and Bad) significantly declined in CoQ10 treated group compared to those of control group. Conclusion: The supplementation of the ovarian culture media with CoQ10 improved the follicular development through alteration in expression of apoptosis-related genes and stimulated the production of estradiol. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2175 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2175/637

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 17 2 2023 06 11 105 108 Ruchita Sinha Department of Obs & Gynae, Tata Manipal Medical College, Jharkhand, India Mamta Datta Department of Obs & Gynae, Tata Main Hospital, Jharkhand, India Vinita Singh Department of Obs & Gynae, Tata Main Hospital, Jharkhand, India 2022 11 21 2023 05 27 Objective: Dengue cases in pregnancy have high morbidity and mortality. More so if it leads to immune thrombocytopenic purpura which causes a drastic decrease in platelet, increasing chances of bleeding and mortality and pregnancy itself being a state of hemodynamic instability. Case report: Here, we present a case of dengue causing secondary immune thrombocytopenia. Managing these cases is challenging and need a multidisciplinary approach and should be done at a higher center. In previous reports, thrombocytopenia in such cases responded to steroids or IVIG. But in our case patient did not respond to either of them but to Romiplostim. There are only a few studies on the use of Romiplostim in dengue and dengue induced ITP and more study is required. Conclusion: Dengue induced persistent thrombocytopenia is rare but should always be kept in mind in managing these cases. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2218 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2218/643

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 17 2 2023 06 11 116 117 Deenadayalan Boopalan Department of Naturopathy, Government Yoga & Naturopathy Medical College & Hospital, The Tamilnadu Dr. MGR Medical University, Chennai, India Vijayakumar Venugopal; Department of Yoga, Government Yoga & Naturopathy Medical College & Hospital, The Tamilnadu Dr. MGR Medical University, Chennai, India Poornima Ravi Government Yoga & Naturopathy Medical College & Hospital, The Tamilnadu Dr. MGR Medical University, Chennai, India Maheshkumar Kuppusamy Department of Physiology, Government Yoga & Naturopathy Medical College & Hospital, The Tamilnadu Dr. MGR Medical University, Chennai, India 2022 10 16 2023 04 09 No Abstract No Abstract No Abstract https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2206 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2206/646

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 17 2 2023 06 11 73 79 EN Anjali Gupta Department of Obstetrics and Gynaecology, Pt B D Sharma PGIMS, Rohtak, Haryana, India Sarika Gautam Department of Obstetrics and Gynaecology, Pt B D Sharma PGIMS, Rohtak, Haryana, India Shelly Chanana Department of Obstetrics and Gynaecology, Pt B D Sharma PGIMS, Rohtak, Haryana, India Neetu Sangwan Department of Obstetrics and Gynaecology, Pt B D Sharma PGIMS, Rohtak, Haryana, India Savita Singhal Department of Obstetrics and Gynaecology, Pt B D Sharma PGIMS, Rohtak, Haryana, India Smriti Anand Department of Obstetrics and Gynaecology, Pt B D Sharma PGIMS, Rohtak, Haryana, India Sonia Dahiya Department of Obstetrics and Gynaecology, Pt B D Sharma PGIMS, Rohtak, Haryana, India 2022 09 07 2023 04 04 Objective: Comparison of two different intervals of misoprostol administration after mifepristone in second trimester abortions. Materials and methods: This 12-month prospective study was conducted at a tertiary care facility. Only pregnancies with congenital deformity or sterilisation failure were included in the study's recruitment of 100 women who visited the hospital for a second trimester abortion between 12 and 20 weeks; cases with scarred uteri were omitted. In a systematic random selection of 50 women in each group, the administration of 200 mg of mifepristone orally was followed by two distinct intervals of intravaginal misoprostol administration at 24- and 48-hour intervals. After 24 hours, group A women received intravaginal 400 mcg misoprostol three hourly, up to a maximum of five doses, while group B received the same doses after 48 hours. Induction abortion interval noted on various parameters and paired t test and chi square test applied. Results: The mean IAI following misoprostol administration was 8.14 2±.03 hours in group A and 7.71 ±2.56 hours in group B. This difference was statistically insignificant. Average misoprostol doses for group A were 1.68±0.71 and for the group, B were 1.68±0.84; both doses were found to be statistically insignificant when used to induce abortion. All women aborted successfully in each group. There was no significant difference in side effects in both groups. Conclusion: Based on the results it was observed that shorter interval between mifepristone and misoprostol i.e., 24 hours can be chosen to decrease the hospital stay as there was no significant difference was seen after intravaginal misoprostol in terms of  induction abortion interval, number of doses and side effects. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2170 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2170/638

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 17 2 2023 06 11 109 112 Elias Mansour Department of Urology, University of Balamand, El-Koura‎, ‎Lebanon Samer Danaf Department of Urology, University of Balamand, El-Koura‎, ‎Lebanon Daniel Ghoussainy Department of Urology, University of Balamand, El-Koura‎, ‎Lebanon Georges Assaf Department of urology, Saint George hospital university medical center, Achrafieh, Lebanon Imad Ghantous Department of urology, Saint George hospital university medical center, Achrafieh, Lebanon Fouad El-Khoury Department of urology, Saint George hospital university medical center, Achrafieh, Lebanon 2022 11 27 2023 05 28 Objective: Present a case of zuclopenthixol associated priapism, literature review and focus on the stuttering priapism entity as a potential serious complication as well as providing information about possible preventive treatments. Case report: A 44 year-old male patient with history of cocaine abuse with associated priapism presents with acute painful erection after starting zuclopenthixol for treatment of a psychotic episode. This episode was later followed by many other similar episodes defined as stuttering priapism. Conclusion: Acute ischemic priapism is a potential serious side effect of antipsychotics that physicians especially psychiatrists needs to be aware of especially if the patient has previous episodes in order to prevent reoccurrence. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2227 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2227/644

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 17 2 2023 06 11 80 85 Maryam Kianpour Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Mina Fazlollahi Mohammadi Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Ashraf Kazami Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Fatemeh Mokhtari Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Sara Arti Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Seyed Mehdi Ahmadi Isfahan Fertility and Infertility Center, Isfahan, Iran 2022 12 17 2023 05 28 Objective: Metabolic syndrome is a risk factor affecting reproductive health and pregnant outcomes. So far, the effect of this syndrome on the success rate of assisted reproduction techniques (ART) has not been investigated. The aim of this study was to investigate the relationship between metabolic syndrome and the success rate of ART in infertile women in Isfahan. Materials and methods: A prospective cohort study performed on 147 women candidates using in-vitro fertilization/ intra cytoplasmic sperm injection (IVF/ICSI) and/or ICSI methods referred to Isfahan Infertility Center in two groups with metabolic syndrome(n=49) without metabolic syndrome(n=98), by convenience sampling methods in Isfahan, Iran in 2018. Body mass index (BMI) and waist, abdominal circumference, Serum triglyceride (TG), cholesterol and FBS were measured. If βHCG test was positive (day 15-16 after ART), transvaginal sonography (TVS) was done 15 days later. Pregnant women were followed up to the 20th week of pregnancy. To analyze, t-test, chi-square and logistic regression tests were used. Results: The frequency of metabolic syndrome was 33.4% (n=49).The frequency of ART was not significantly different between women with and without metabolic syndrome (p=0.321). The relative frequency of pregnancy (p=0.907) and abortion (p=0.896) did not show a significant difference between the two groups. Independent t-test showed that the mean FBS, HDL, TG, systolic and diastolic BP, abdominal circumference and BMI in the studied units did not differ significantly based on the occurrence of pregnancy and abortion. Conclusion: According to the results of this study, there was no significant difference between the indicators of metabolic syndrome and the success rate of ART in achieving, pregnancy and pregnant outcomes in the first twenty weeks of pregnancy. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2244 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2244/639

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 17 2 2023 06 11 113 115 Carolina Quental USF Prelada Daniel Brito Family Health Unit, Espaço Saúde, Porto, Portugal João Sobral Family Health Unit, Baltar, Paredes, Portugal Ana Mafalda Macedo Family Health Unit, Prelada, Porto, Portugal 2023 01 31 2023 05 28 Objective: In Raynaud's phenomenon of the nipple there is a change in color, accompanied by pain or discomfort during breastfeeding. Case report: A 29-years old female patient, breastfeeding, develops a severe bilateral nipple pain during and after breastfeeding and biphasic change in nipple color, with difficulties in the breastfeeding technique. She was medicated with nifedipine and recommended application of warm compresses to the nipples and use of electric breast pump, showing complete resolution after four weeks of treatment. Conclusion: Raynaud's phenomenon of the nipple should be considered in breastfeeding women who report nipple pain or discomfort. In clinical practice, nipple pain is a very frequent complaint, and responsible for many cases of early abandonment of breastfeeding. It is therefore essential to make an early diagnosis and implement a correct and immediate treatment. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2278 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2278/645

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 17 2 2023 06 11 86 92 Hadis Bahmaei Department of Midwifery, Faculty of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Parvaneh Mousavi ReproUS">Objective: Internalized transphobia (IT) is influenced by societal norms and expectations, and it can have significant negative effects on the well-being and mental health of transgender individuals. The aim of this study was to translate and evaluate the psychometric properties of the Persian 8-item IT scale among Iranian transgender individuals in order to enhance the quality and quantity of research in this field. Materials and methods: This cross-sectional and methodological study utilized convenience sampling to recruit 119 transgender individuals in Mashhad, the second most populous city in Iran, in 2021. The Persian translation of the IT scale was developed using the backward-forward translation method. Subsequently, various types of validity and reliability were assessed, including content validity using the content validity index (CVI) and content validity ratio (CVR), face validity based on the impact score, construct validity through confirmatory factor analysis (CFA), internal consistency measured by Cronbach's alpha, and test-retest stability analyzed using the intraclass correlation coefficient (ICC). Results: The CVR ranged from 0.600 to 1, the CVI ranged from 0.800 to 1, and the impact score exceeded 1.5, indicating the appropriate content and face validity of the 8-item IT scale. The construct validity analysis revealed that the questionnaire is one-dimensional. The internal consistency, as measured by Cronbach's alpha, was 0.917, and the ICC for test-retest stability was 0.871. Conclusion: The Persian version of the IT scale demonstrated high and acceptable psychometric properties. The brevity of this scale facilitates its dissemination and utilization in clinical settings. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2560 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2560/673

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 18 1 2024 05 07 53 59 Osama Deif Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt Mohammed Messalami doctor of obstetrics and gynecology Yasser Diab Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt 2024 01 30 2024 03 18 Objective: Precise assessment of cervical conditions before labor induction is crucial for predicting the success of normal vaginal delivery. The cervix primary condition has a significant value in determining the succession of induction of labour. Traditionally, assessment of cervix before induction has been based on a cervix digital examination using Bishop's scoring method.This study compares transvaginal ultrasonographic (TVS) cervical assessment with the traditional Bishop score in nulliparous women undergoing labor induction, aiming to evaluate their predictive abilities for labor dystocia. Materials and methods: In a prospective observational study of 200 pregnant women at Al Hussein University Hospital between October 2022 and July 2023, cervical length, funneling, and posterior cervical angle were measured using transvaginal ultrasound. The Bishop score was recorded before induction. Statistical analyses, including Student's "t"-test and ROC curve, were conducted using SPSS. Results: 68% delivered via normal vaginal delivery (NVD) and 32% via cesarean section (CS). The NVD group exhibited significantly higher Bishop scores (6.82±1.36 vs 3.70±0.94), lower cervical length (25.46±3.99 vs 37.34±2.09),and higher cervical angle (121.39±5.70 vs 89.01±6.09), than the CS group. ROC curve analysis revealed that a Bishop score ≥4.5 had 89% sensitivity and 87.5% specificity, a cervical angle ≥ 92.5 had 98.5% sensitivity and 95.3% specificity, and a cervical length ≥31.5 had 96.9% sensitivity and 97.1% specificity for predicting NVD. Conclusion: The posterior cervical angle, alongside cervical length, proves to be a more sensitive indicator for predicting labor dystocia during induction compared to the traditional Bishop score.   https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2607 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2607/674

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 18 1 2024 05 07 60 66 Maryam Abasalizadeh Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran Farideh Kazemi Mother and Child Care Research Center, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran Soodabeh Aghababaei Mother and Child Care Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Behnaz Basiri Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran Farzaneh Soltani Mother and Child Care Research Center, Hamadan University of Medical Sciences, Hamadan, Iran 2024 02 01 2024 03 18 Objective: Having a preterm infant is a stressful experience for parents, especially for mothers. This study was conducted to identify the effect of kangaroo mother care on the resilience of mothers with preterm infant hospitalized in Neonatal Intensive Care Unit. Materials and methods: In this randomized controlled trial study, 60 mothers with preterm infant hospitalized in Neonatal Intensive Care Unit were randomly selected and allocated to intervention and control groups (30 per group) ,in Fatemiyeh Hospital, Hamadan, Iran. Data collection tool included demographic information and Conner & Davidson Resilience Questionnaire (CD-RISC), which were completed by mothers before and after the intervention. Kangaroo Mother Care (KMC) as an intervention was run in at least one hour daily for a week in the intervention group. The mother-infant pairs in the control group only received conventional method of care (CMC). Results: There was a significant increase in the total resilience score of the mothers in the KMC group (from 58.87±14.71 to 69.67±14.50) after intervention (P<0.001); however, resilience score decreased significantly in the mothers of CMC group (from 57.77±13.33 to 51.63±12.20). Conclusion: Kangaroo mother care could increase the resilience of mothers of preterm infants. Therefore using this approach as a complementary, effective, Low-cost, non-invasive care is recommended to maintain and promote the health of mothers with preterm infant. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2611 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2611/675

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 18 1 2024 05 07 67 74 Maryam Dehshiri Department of Midwifery, Islamic Azad University, Meybod, Iran Mehrdad Mansouri Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mohammad Hossein Jarahzadeh Department of Anesthesiology and Critical Care, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Nooshin Hatamizadeh Department of Obstetrics and Gynecology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 2024 02 26 2024 03 18 Objective: The rate of COVID-19 vaccination hesitation among Iranian pregnant wome