Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 15 2 2021 06 20 74 81 Nasibeh Roozbeh Mother and Child Welfare Research Center, Hormozgan Universiy of Medical Sciences, Bandar Abbas, Iran Azam Amirian Department of Midwifery, School of Nursing and Midwifery, Jiroft University of Medical Sciences, Jiroft, Iran Fatemeh Abdi School of Nursing and Midwifery, Alborz University of Medical Sciences, Karaj, Iran Simin Haghdoost Department of Midwifery, Urmia Branch, Islamic Azad University, Urmia, Iran 2020 12 29 2021 04 20 Objective: Male infertility is involved in about half of the casess of infertility and the only sole reason for infertility in 20%-30% of the cases. Following the recent interest in the use of medicinal plants, scientists have sought to clarify their effects on male fertility. This review aimed to summarize the results of studies available to determine the effectiveness, safety and mechanism of herbal treatments in the improvement of male fertility. Materials and methods: Medline/PubMed, Scopus, Science Direct, and the Cochrane Central Register of Controlled Trials (Central) databases were searched for randomized controlled trials (RCTs) published during 2000-2020. Studies were only included if they adhered to the CONSORT checklist. The methodological quality of the selected studies was assessed using the Cochrane risk of bias tool. Results: Finally, 20 studies recruiting a total of 1519 individuals were reviewed. These studies compared the effects of eleven different medicinal plants, i.e. ginseng, saffron, Nigella sativa, palm pollen, ADOFON, TOPALAF, sesame, and Mucuna pruriens, on male fertility with those of placebo. All studies (except one) confirmed the beneficial effects of medicinal plants on the improvement of sperm and reproductive parameters and thus male infertility. Conclusion: The existing RCTs indicated the positive effects of medicinal plants on male fertility. Therefore, in order to develop a novel approach to the treatment of male infertility, further clinical trials are warranted to determine the maximum dosage and duration of treatment with herbal medicines and evaluate any potential side effects of such interventions. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1656 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/1656/556

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 15 2 2021 06 20 82 90 EN Ernest Kirui Institute of Tropical and Infectious Diseases, College of Health Sciences, University of Nairobi, Nairobi, Kenya Joseph Mung'atu Department of Statistics and Actuarial Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya Peter Gichangi Department of Human Anatomy, College of Health Sciences University of Nairobi, Kenya Nicholas Onguto Department of Community Health, Kenyatta University, Nairobi, Kenya Davis Kamondo Institute of Tropical and Infectious Diseases, College of Health Sciences, University of Nairobi, Nairobi, Kenya 2020 12 26 2021 04 20 Objective: The recent increase in the uptake of injectable contraceptives has occurred at the expense of the other modern contraceptive methods but the knowledge gap still exists on modeling dynamics and determinants associated with the use of the injectable. This study sought to model for injectable contraceptive usage to bridge the knowledge gap on the use of injectable contraceptives among women of childbearing age in Kenya. Materials and methods: Analytical cross-sectional study design was adopted. Secondary data for women collected during the (Performance Monitoring for Action) PMA2020 survey was used. PMA2020 survey used multistage stratified sampling with urban-rural representation. To establish the factors associated with the uptake of injectable contraceptives, a multiple logistic regression model was fitted using Stata version 13 and R version 3.5.3 statistical software. Hosmer-Lemeshow Test statistic was used to evaluate the goodness of model fit in predicting injectable contraceptive usage. Results: Multivariable analysis showed that women with post-primary/vocational levels of education were 54% less likely to use an injectable contraceptive compared to those who had no education at all. Hosmer-Lemeshow (HL) goodness of fit test statistic indicated that the model was a good fit for prediction. Education, marital status, wealth quintile, place of residence and number of births were significant predictors of the injectable contraceptive uptake among women of reproductive age in Kenya. Conclusion: The findings of this study will inform the design of targeted interventions aimed at addressing the increasing demand for injectable devices among women of reproductive age in Kenya. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1644 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/1644/557

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 15 2 2021 06 20 125 129 Amrita Talwar Department of Pathology, Postgraduate Institute of Medical Sciences, Ram Manohar Lohia Hospital, New Delhi, India Pushpanjali Behera Department of Pathology, Postgraduate Institute of Medical Sciences, Ram Manohar Lohia Hospital, New Delhi, India Arvind Ahuja Department of Pathology, Postgraduate Institute of Medical Sciences, Ram Manohar Lohia Hospital, New Delhi, India Bani Sarkar Department of Obstetrics & Gynecology, Postgraduate Institute of Medical Sciences, Ram Manohar Lohia Hospital, New Delhi, India Ravi Phulware Department of Pathology, All India Institute of Medical Sciences, Rishikesh, India 2020 12 01 2021 03 13 Objective: Endometrial cancer (EC) is the most commonly diagnosed malignancy and has the second-highest mortality rate among gynecological cancers. Adenomyosis is well-known for abnormal uterine bleeding and is a widely reported entity; however, an EC arising from the adenomyosis is a rare event; even rarer is the occurrence of serous endometrial carcinoma. Case report: A 60-year post-menopausal female presented with post-menopausal bleeding. Subsequently, she underwent a hysterectomy, which showed atrophic and cystic endometrium with extensive adenomyosis and atypical endometrial glands, which are diffusely P53 positive with intervening negative benign and focally positive dysplastic endometrial glands. A final diagnosis of serous endometrial carcinoma arising from adenomyosis was rendered. In a table format, previously reported serous endometrial carcinoma Arising cases from adenomyosis using PubMed search had been described. Conclusion: Serous endometrial carcinoma arising from adenomyosis (<20 cases reported) and has a slightly more dismal prognosis than those deriving from the endometrial cavity. Hence, this case report highlights the occurrence, rarity, and importance of such an entity. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1622 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/1622/563

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 15 2 2021 06 20 91 98 EN Maryam Dehghan Anatomy Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Shirin Shahbazi Medical Genetic Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Mojdeh Salehnia Anatomy Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran 2020 12 31 2021 04 20 Objective: The aim of this study was to evaluate the effect of lysophosphatidic acid (LPA) supplementation during in vitro culture and transplantation of mouse ovaries on the follicular development and expression of vascular endothelial growth factor (VEGF) as an angiogenesis factor at the mRNA and protein levels. Materials and methods: Three weeks old mice ovaries were cultured in the presence and absence of LPA for 24 hours, then they were capsulated in sodium alginate in the presence and absence of LPA as four experimental groups. After transplantation the vaginal smears were performed daily to evaluate the initiation of the estrous cycle. The morphology and follicular distribution were analyzed at the first and fourth estrous cycles using hematoxylin and eosin staining. Then in the groups that showed higher and lower follicular development the immunohistochemistry assay was conducted to identify VEGF protein expression, and the real time RT-PCR was done to analyze the expression of Vegf gene at the first estrus cycle. Results: The large size follicles and also the corpus luteum were prominent in all transplanted groups at fourth estrus cycle in comparison with intact control groups. The statistically lowest percentage of small size follicles and the highest percentages of large size follicles were seen in LPA+/LPA- group (p<0.05). The expression ratio of Vegf to β-actin was significantly higher in this group in comparison with non-LPA treated and intact control groups (p <0.05). Conclusion: LPA as an angiogenesis factor increases the follicular development in transplanted ovaries but it causes early discharge of ovarian reserve. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1657 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/1657/558

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 15 2 2021 06 20 130 135 Laura González- Teshima School of Medicine, Valle University, Cali, Colombia César Payán-Gómez Department of Biology, Faculty of Natural Sciences, Rosario University, Bogotá, Colombia Wilmar Saldarriaga School of Basic Sciences, Valle University, Cali, Colombia AND School of Medicine, Valle Hospital, Valle University, Cali, Colombia 2020 11 05 2021 03 13 Objective: To evidence the need for screening fragile X syndrome (FXS) in egg donors in assisted reproduction protocols. Case report: This is the report of a boy with FXS who inherited the mutated allele from an ovule donated by the mother´s sister through an assisted reproduction protocol. Identifying premutation (PM) carriers of FXS amongst gamete donors isn’t part of the obligatory genetic analysis for donors and is only considered by most of the in vitro fertility societies and guidelines as part of the extension screening tests. Conclusion: It is cost-effective to do pre-conceptional screening for the PM or full mutation (FM) of the FMR1 gene affected in FXS in every woman undergoing assisted reproductive methods, including gamete donors even without a positive family history of intellectual disabilities. This case supports the need of rethinking the guidelines on the necessary gamete donor screening tests in assisted reproduction protocols. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1598 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/1598/564

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 15 2 2021 06 20 99 105 Ziba Mosayebi Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran Setareh Sagheb Department of Neonatology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Mahsa Mirzendedel Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran Amir Hossein Movahedian Bahrami Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran 2020 11 07 2021 04 04 Objective: Vitamin D deficiency is a major health problem in all age groups. In the present study, we aimed to determine the prevalence of vitamin D deficiency in neonates hospitalized in an intensive care unit (NICU) and its association with clinical neonatal outcomes. Materials and methods: A prospective cross-sectional study was carried out on all neonates hospitalized in the NICU of Children's Medical Center over a period of one year (January–December 2018). Immediately on admission, a serum sample for vitamin D measurement was obtained with another routine blood sampling. Demographic and clinical data including sex, gestational age, the season of birth, serum levels of vitamin D and calcium, the causes of hospitalization, age at admission and neonatal outcomes including length of hospital stay and mortality during hospitalization were assessed. Results: One hundred neonates entered the study. Vitamin D deficiency and insufficiency were present in 95% of neonates. There was a significant association between vitamin D status and birth during winter (p=0.014); hypocalcemia (p=0.025) and older age at NICU admission (p<0.001). The mean value of vitamin D in term neonates was significantly lower than in preterm neonates (p=0.031). There were no correlations between length of hospital stay and neonatal mortality rate with vitamin D status (p=0.876). Conclusion: Vitamin D deficiency and insufficiency were highly prevalent among NICU patients. Maternal vitamin D supplementation during pregnancy may prevent or reduce the risk of low levels of vitamin D in neonates. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1600 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/1600/559

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 15 2 2021 06 20 136 140 Lajya Goyal Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Bathinda, India Priyanka Garg Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Bathinda, India Manmeet Kaur Department of Pathology, All India Institute of Medical Sciences, Bathinda, India Diksha Sharma Guru Gobind Singh Medical College, Faridkot, Punjab, India 2021 01 13 2021 05 01 Objective: Dermatofibrosarcoma protuberans (DFSP) of the vulva is an uncommon soft tissue tumor with fewer than 60 cases reported previously. Distant metastasis is rare with a high propensity for local invasion. Surgical management is the gold standard with adequate margin excision to prevent future recurrences. We report a case of vulvar DFSP requiring three resections to achieve primary clearance. To the best of our knowledge, this is the first case report from India. Case report: A 35-years-old female, presented with nodular vulvar mass for the third time arising from the upper part of right labia majora for the last year. She had a history of two similar episodes in the pauthor> Azadeh Tarafdari Menshadi Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran Mamak Shariat Maternal, Fetal & Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran Saiedeh Shahsavari Department of Obstetrics and Gynecology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Fedyeh Haghollahi Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran Elham Azimi Nekoo Jacobi Medical Center / Albert Einstein University, New York, United States 2023 06 13 2023 08 15 Objective: Platelet Rich Plasma (PRP) is proposed to have important role in cell division and proliferation, angiogenesis and health. This study evaluates the effect of a single injection of autologous PRP on ovarian response markers in women with poor ovarian response (POR). Materials and methods: This non-randomized clinical trial was conducted between August 2020 and September 2021. Fifty six women with Bologna criteria for POR willingly chose to participate in one of the following groups: PRP for one cycle in the time of oocyte pickup (OPU) (intervention group, n= 34) or control group (n=22).The primary outcomes were: number and quality of oocytes in coming 2 cycles of ICSI, and Anti Mullerian Hormone (AMH) level two months after PRP injection. The secondary outcomes were the number and quality of embryos and chemical pregnancy rate after embryo transfer. Results: A total of 45 participants continued the study, of which 23 were in the intervention group and 22 in control group. There were no demographic differences between two groups. At a two cycle follow up, PRP group experienced a significant improvement in AMH level and there was no respective change in control group. In one year follow up the overall pregnancy rates were same in both groups (3% Vs. 0, p=.60), while there was no difference in cumulative number and quality of embryos. Conclusion: PRP injection can improve ovarian reserve marker without adverse effects. Further evidence is required to evaluate the impact of PRP on assisted reproduction outcomes. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2400 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2400/652

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 17 3 2023 09 03 174 178 Fateme Salehi Department of Obstetrics and Gynecology, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran Sara Saeedi Department of Obstetrics and Gynecology, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran Zeynab Amiriariya Department of Obstetrics and Gynecology, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran Elham Feizabad Department of Obstetrics and Gynecology, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran 2023 06 21 2023 08 15 Objective: Pelvic access is a challenging matter in abdominal hysterectomy especially in obese patients and presence of pelvic adhesions. Uterus manipulators (UM) have been used in a number of studies on laparoscopic approach to improve surgical performance. This study aimed to assess the impact of UM application on the operation time and blood loss in total abdominal hysterectomy (TAH) for benign diseases. Materials and methods: Forty-one patients aged 34 to 56 years were enrolled for abdominal hysterectomy – 20 as the case group (hysterectomy with UM application) and 21 as the control group (conventional hysterectomy). In the case group, UM was used after uterus artery ligation during TAH. The control group underwent traditional TAH. Results: The mean operation time was significantly less in TAH with UM compared to traditional TAH (90.23 ± 10.54 minutes vs. 140.5 ± 16.61 minutes; p-value<0.001). The mean decline between preoperative and 12-hour postoperative hemoglobin was 0.74 ± 0.23 mg/dL in the TAH with UM group and 1.65± 1.02 mg/dL in the traditional TAH group (p-value<0.001). Also, no difference was detected in intra- and post-operative complications. Conclusion: The current study showed that, using UM is beneficial in total abdominal hysterectomy by decreasing the operative time and blood loss. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2412 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2412/653

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 17 3 2023 09 03 179 184 Azadeh Shabani Preventative Gynecology Research Center (PGRC), Department of Obstetrics and gynecology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mahshid Farahbakhsh School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Azadeh Mazaheri Meybodi Hospital Research Development Committee and Department of Psychiatry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Nafiseh Faghih Gynecology Department, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Haddadi Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran 2023 07 26 2023 08 16 Objective: Postpartum depression (PPD) is a common mental disorder among women and it can cause negative consequences for them, children, and families; however, accurate statistics and underlying factors on PPD and its severity are not available in Iran. Materials and methods: In this cross-sectional study, 200 women referred to an academic hospital for normal vaginal delivery, which had a full-term and single pregnancy and had passed between 6 weeks and 6 months of delivery, were selected by convenience sampling methods. The Edinburgh Depression Inventory and the checklist for demographic information of mothers were completed. Results: The prevalence of postpartum depression was 11.0% and 68.2% of mothers had a mild type. 31.8% had a history of depression. There was a significant relationship between the severity of postpartum depression in women with a previous history of depression (P = 0.012). Between postpartum depression and maternal age (P = 0.115), body mass index at delivery (P = 0.571), number of pregnancies (P = 0.693), number of deliveries (P = 0.446), number of abortions (P = 0.424), willing or unwilling pregnancy (P = 0.451), neonatal sex (P = 0.533), history of neonatal hospitalization (P = 0.725), previous history disease (P = 0.725) was no statistical association. Conclusion: The prevalence of PPD was approximately 11%, and there was a significant association between postpartum depression severity and a history of depression Physicians and policymakers should consider early screening for PPD, especially among women with previous depression. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2438 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2438/654

Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 17 3 2023 09 03 185 190 Iraj Shahramian Department of Pediatrics, Zabol University of Medical Sciences, Zabol, Iran Leli Rezaie Kahkhaie Department of Internal Medicine, School of Medicine, Amiralmomenin Hospital, Zabol University of Medical Sciences, Zabol, Iran Khadije Rezaie Keikhaie Department of Obstetrics and Gynecology, School of Medicine, Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran Mahdi Shirdel Kahkha Zhaleh Student Research Committee, Zabol University of Medical Sciences, Zabol, Iran Mahdi Afshari Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran 2023 07 16 2023 08 16 Erratum. J Family Reprod Health. 2023;17(4):270.DOI: https://doi.org/10.18502/jfrh.v17i4.14667 Objective: Changes in endocrine, nervous, renal, cardiovascular, and respiratory systems during pregnancy have been studied, but changes in liver function have been poorly studied. Therefore, the purpose of this study was to investigate the trend of