Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 4 3 2010 09 15 105 107 Zohreh Mazaheri Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Samad Muhammadnejad Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran Ahad Muhammadnejad Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran Moein Zargarzadeh Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran Maryam Haghighi Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran Mohammad Ali Oghabian Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran Farrokh Tirgari Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran Saeid Amanpour Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran 2015 10 04 Objective: To evaluate the potentiality of OVCAR–3 cell line of ovarian adenocarcinoma as a xenograft model for ovarian adenocarcinoma in nude mice. Materials and methods: The cell line isolated from advanced human ovarian adenocarcinoma, were inoculated to eight nude mice and two months later. Established tumors were transferred to pathology laboratory to be prepared by H&E staining and immunohistochemical staining with CA125 antibody. Results: Study of H&E slides showed advanced adenocarcinoma. The CA125 Tumor marker was also positive in tumoral tissue. Conclusion: Established tumors showed excellently the characteristics of ovarian adenocarcinoma. This model can be used to evaluate new treatment strategies. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/99 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/99/99