Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 4 3 2010 09 15 95 104 Afsaneh Bakhtiary Institute of Gerontology, University Putra Malaysia, Serdang, Selangor, Malaysia AND Department of Midwifery, Faculty of Medicine, Babol University of Medical Sciences, Iran Zaitun Yassin 1.Institute of Gerontology, University Putra Malaysia, Serdang, Selangor, Malaysia. AND Department of Nutrition & Dietetics, Faculty of Medicine & Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia Parichehr Hanachi Faculty of Basic Science, Department of Biology, Biochemistry unite, Alzahra University Tehran, Iran Asmah Rahmat Department of Nutrition & Dietetics, Faculty of Medicine & Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia Zaiton Ahmad Department of Family Medicine, Faculty of Medicine & Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia Farzad Jalali Department of Cardiology, Faculty of Medicine, Babol University of Medical Sciences, Iran 2015 10 04 Objective: To ascertain the effects of soy [in the forms of Textured Soy Protein (TSP) and soy-nut] on lipid profiles, apolipoproteins, inflammatory and prothrombotic markers and blood pressure in elderly women with the metabolic syndrome. Materials and methods: The study is a 12-week parallel randomized controlled trial that was conducted in rural health centres of Babol, Iran. The participants were 75 women 60-70 years old with the metabolic syndrome who were randomized to one of the three groups of soy-nut (35g/d), TSP (35g/d) and control. Blood pressure and blood biochemical markers were measured at baseline and at the end of the study including, triglyceride, cholesterol, HDL-C, LDL-C, VLDL-C, ApoB100, ApoAI, CRP and fibrinogen. Results: The soy-nut improved significantly LDL-C, VLDL-C and Apo B100 (P<0.05) while fewer improvements but significant were observed in these variables in the TSP group only when compared with the mean changes from the baseline (P<0.001). Similar result was found for Apo AI in the treatment groups (P<0.01). Serum total cholesterol decreased significantly in the  treatment groups compared with control group (P<0.005). The differences from control for triglyceride, HDL-C, fibrinogen, CRP and blood pressure were not significant. Conclusion: Both forms of soy while improved lipids profiles the soy-nut contribution was more to this improvement than the TSP. Therefore, moderate daily intake of soy may be a safe, cheap and practical method to improve cardiovascular disease risk and also reduce the need for medical treatment. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/98 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/98/98