Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 6 4 2012 11 08 145 151 EN Farideh Zafari-Zangeneh Tehran University of Medical Sciences, Vali-e-Asr, Reproductive Health Research Center, Imam Khomeini Hospital Complex, Tehran, Iran. Mohammad Mehdi Naghizadeh Department of Community Medicine, Medical faculty, Fasa University of Medical Sciences, Fasa, Iran. Nasrin Abedinia Tehran University of Medical Sciences, Vali-e-Asr, Reproductive Health Research Center, Imam Khomeini Hospital Complex, Tehran, Iran. Fedyeh Haghollahi Tehran University of Medical Sciences, Vali-e-Asr, Reproductive Health Research Center, Imam Khomeini Hospital Complex, Tehran, Iran. Davoud Hezarehei Department of clinical psychology, Tarbiatmodarres University, Tehran, Iran. 2015 11 02 2015 11 02 Objective: PCOS is a multifaceted disorder with multiple potential risk factors (e.g. infertility, diabetes,cardiovascular disease and metabolic syndrome). PCOS affects quality of life and can worsen anxiety and depression either due to the features of PCOS or due to the diagnosis of a chronic disease. This study aimed to determine the risk factors of PCOS in a group of patients. Materials and methods: In this descriptive-analytic study, 81 patients with PCOS were studied in Vali-e-Asr Reproductive Health Research Center, Tehran, Iran. A questionnaire with items related to stress information was used for data collection. Stress  symptoms were assessed using the Understanding Yourself standard questionnaire. Statistical analyses were performed using SPSS 13.0 (SPSS Inc., Chicago, ILL, USA). Data are presented as mean ± SD or as frequency with percentages. P-value less than 0.05 were considered as statistically significant. Results: The evaluation of psychological signs in 81 PCO patients and descriptive results showed that 8 (9.9%) had not any stress problem, 32 (39.5%) had neurotic stress, 29 (35.8%) had high level and 12 (14.8%) had extremely high level of stress. The age range of 26 years and more (P=0.023), touchy personality (P = 0.028) and acne (P = 0.015) related with high stress level. The odds of high level of anxiety in women with hirsutism was 3.1 (95%CI 1.00 to 9.59). The odds of high level of obsession in overweight patients was 3.2 (95%CI 1.12 to 9.234). The odds of high level of worrisome in patients with touchy personality was 3.4 (95%CI 1.10 to 11.19). Obsession score had a correlation with illness duration (r = -0.268, P = 0.038). Conclusion: These data showed that clinical signs of PCOS are the most closely associated with psychological distress and this  has important implications for the diagnosis and treatment of  disorders. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/334 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/334/325