Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 18 3 2024 10 05 160 163 Samira Abodollahi Department of Obstetrics and Gynaecology, Alborz University of Medical Sciences, Alborz, Iran Shamimeh Poorbahri Ghesmat Cardiovascular Research Center, Alborz University of Medical Sciences, Alborz, Iran Mahsa Khoshnam Rad Midwifery and Reproductive Health Department, Alborz University of Medical Sciences, Alborz, Iran Kamran Behrouzi Department of Neonatology, Alborz University of medical Sciences, Alborz, Iran 2024 04 24 2024 09 01 Objective: Oxytocin is commonly used during labor and delivery for induction of labor and prevention of postpartum hemorrhage. While previous studies have explored the effects of labor oxytocin use on maternal and neonatal outcomes, there is a paucity of research on its impact on newborn liver enzyme function. This study aimed to assess the effects of labor oxytocin use on liver enzyme function in newborns. Materials and methods: A case-control study was conducted. The case group consisted of 70 newborns whose mothers received oxytocin during labor, while the control group consisted of 70 newborns whose mothers did not receive oxytocin. Complete blood count (CBC), lactate dehydrogenase (LDH), creatine phosphokinase (CPK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total and indirect bilirubin levels were measured in all newborns on the second day of life. Results: The levels of AST and total and indirect bilirubin were found to be higher in the case group than in the control group (51 vs. 42, 7.8 vs. 4.6, and 7.4 vs. 4, respectively; p < 0.005). The levels of CPK and LDH were also higher in the case group (p < 0.005). However, the difference in ALT levels was not significant between the study groups. Conclusion: The observed increase in liver enzymes in this study can indicate the effect of maternal oxytocin on the newborn's liver function. While the changes in liver enzyme levels due to oxytocin use were not found to be high enough to cause liver damage, the increase in CPK and LDH levels could potentially elevate bilirubin levels due to hemolysis. Further research is needed to confirm these findings and explore the underlying mechanisms. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2712 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2712/690