Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 18 1 2024 05 07 1 8 Nauryzbay Imanbayev Department of Oncology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan Yerbolat Iztleuov Department of Radiologists of the NJSC ZKMU named after Marat Ospanov, MC NCJSC Marat Ospanov Western-Kazakhstan Medical University, Aktobe, Kazakhstan Arip K. Koishybaev Department of Oncology of the NJSC ZKMU named after M. Ospanov MC NCJSC Marat Ospanov Western-Kazakhstan Medical University, Aktobe, Kazakhstan Nurgul Kereyeva Department of Oncology ZKMU named after Marat Ospanova, MC NCJSC Marat Ospanov Western-Kazakhstan Medical University, Aktobe, Kazakhstan Anar Tulyayeva Department of Oncology Medical Center of West Kazakhstan Medical University named after Marat Ospanov, Aktobe, Kazakhstan Dinara Zholmukhamedova Department Oncology MC NCJSC Marat Ospanov Western-Kazakhstan Medical University, Aktobe, Kazakhstan Azamat Zharylgapov Department Oncology MC NCJSC Marat Ospanov Western-Kazakhstan Medical University, Aktobe, Kazakhstan 2024 02 20 2024 03 09 Objective: To evaluate the implications and significant role of parenchymal and stromal ratio in colorectal cancer (CRC). Materials and methods: In our review, we involved English studies from common databases such as Web of Science, Scopus, Google Scholar, PubMed, and the Cochrane Library using the following keywords “colorectal cancer”, “tumor stromal ratio”, “tumor parenchymal ratio”, and “prognostic marker” till December 2023. Results: The majority of CRC patients are usually diagnosed at late stages, which may lead to missing out on the chance to get radical therapy. Patients with unfavorable prognosis have epithelial malignant tumors with a high amount of stroma, more than 50% stroma, while tumors with a low amount of stroma, less than 50%, and abundant carcinoma tissue have a better prognosis. Conclusion: Tumor-stromal ratio is a valuable, cheap, and fast modality that provides valuable prognostic data of colorectal carcinoma and other cancers.   https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2635 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2635/668