Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 17 2 2023 06 11 93 99 Rayhan Islam School of Health & Life Sciences, North South University, Dhaka, Bangladesh Khandakar Shafiur Rahaman RANAS Ltd. – Spin-off of Eawag, Zurich, Switzerland AND London School of Hygiene and Tropical Medicine, London, UK Mohammad Hawlader Department of Public Health, North South University, Dhaka, Bangladesh 2023 01 03 2023 05 28 Objective: Erectile dysfunction (ED) is a common cause of sexual disorders in men with limited treatment options. This study aimed to determine the efficacy of low-intensity extra corporal shockwave therapy (LI-ESWT) in patients suffering from ED. Materials and methods: A single-group, pre-test, and post-test pre-experimental study were conducted. Thirty-one ED patients were prospectively selected according to the eligibility criteria. In each session, 3000 shocks were applied at 5 points over the penis. Eight sessions were delivered in total with a 2–3-day interval. The patient’s condition was assessed using the International Index of Electric Function (IIEF-5) questionnaire at baseline and one month after the last treatment session. Paired t-test was used to determine the difference between the pre-test and post-test. Results: Mean age of the patients was 44.6 (± 14.70) ranging from 25 to 78 years. The majority of them were married (83.9%) and service providers (51.6%). We have also found 51.6% overweight, 9.7% obese, 48.4% diabetic, 45.2% hypertensive, 12.9% with enlarged prostate, 45.2% smoker, 25.8% alcoholic, and 71% with sleep disturbances. During the pre-test, 9.7% had severe ED and 51.6% had moderate ED. After the treatment, no patients were found with severe ED, and few of them had moderate ED (9.7%). The mean difference in IIEF-5 score during the pre-test and post-test was statistically significant (p= < 0.001). Conclusion: The study showed efficacy of LI-ESWT in a subset of patients with ED. Future studies with larger sample size, placebo group, and longer follow-up periods are recommended. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/2252 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/2252/641