Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 8 4 2014 12 15 169 173 Raha Afshariani Department of Public Health, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran. Jamshid Roozbeh Urology Nephrology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran. Maryam Sharifian Department of Neurology, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Mahbobeh Ghaedi Urology Nephrology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran. Alamtaj Samsami Dehaghani Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran. Abbas Ghaderi Shiraz Institute of Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran. 2015 10 16 Objective:To determine the possible association between the M235T variant of angiotensinogen gene and preeclampsia in Iranian preeclamtic women with hypertension during pregnancy. Mand methods:During a case control study, we used polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analysis to investigate the association between M235T polymorphism in preeclamtic women compared to normotensive controls. Results:The M235T polymorphism was significantly associated with increased preeclampsia risk in the studied population as supported by a p value of 0.017 and chi-square value of 8.12. The frequency of mutated allele and genotype distribution showed a significant difference between preeclamtic women and control groups. Conclusion:The result indicates that the AGT M235T polymorphism plays a significant role in preeclampsia observed in selected Iranian preeclamtic women, and it can be considered as a major risk factor for preeclampsia. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/190 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/190/185