Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 15 4 2021 11 28 242 247 Alireza Karimi Yazdi Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran Parvin Akbariasbagh Department of Pediatrics, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Yahya Aghighi Department of Pediatrics, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Seyyed Reza Raeeskarami Department of Pediatrics, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Khadije Toomaj Department of Pediatrics, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Sahar Heidari Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran Shahnaz Alamdari Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran Leyla Sahebi Family Health Research Institute, Maternal-Fetal, and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran 2021 04 15 2021 08 24 Objective: Kawasaki disease (KD) occurs in five-year-old or younger children. This study aimed to evaluate the impact of high-dose intravenous immunoglobulin plus acetylsalicylic acid therapy on the prevention and treatment of coronary artery lesions and to evaluate the impact of high-dose acetylsalicylic acid (ASA) on the hearing of the patients. Materials and methods: In this retrospective cohort study, 31 patients with KD were followed from January 2012 to December 2015. The clinical, para-clinical, color Doppler echocardiogram and audiometry results were evaluated. Results: Overall, seven cases (22.6%) developed coronary artery aneurysm (CAA) in the acute phase of the disease, of whom only two still had CAA at the end of the treatment (6%). One of the five children with CAA recovery had a delay in the onset of treatment and one of two patients with persistent CAA at the end of treatment was admitted within the first 10 days. There was no evidence-based abnormal liver biochemical test. None of the patients developed sensorineural hearing loss (SNHL) on audiometry tests conducted before and after treatment. Conclusion: Recovery of coronary artery lesions was 71.43% after 28 days of the onset of treatment. The distribution of coronary artery aneurysm was not different in terms of the time of the treatment initiation (P-Value = 0.371). None of the children had a sensorineural hearing loss (SNHL) 48 hours and 4 weeks after treatment. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1756 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/1756/580