Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 6 3 2012 09 14 95 98 Zhila Amirkhani Islamic Azad University Research Center, Medical Tehran Branch, Tehran, Iran Meisam Akhlaghdoust Functional Neurosurgery Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Ir Gelareh Salehi Young Researchers Club, Tehran Medical Branch, Islamic Azad University, Tehran, Iran Ehsan Jangholi Young Researchers Club, Tehran Medical Branch, Islamic Azad University, Tehran, Iran Mohamadreza Sadeghi Students' Research Committee, Tehran Medical Branch, Islamic Azad University, Tehran, Iran Farima Ghenaat Students' Research Committee, Tehran Medical Branch, Islamic Azad University, Tehran, Iran Nesa Zarbati Department of Medical Genetics & Sarem Cell Research Center, Sarem Hospital, Tehran, Iran Mina Jafarabadi Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran 2015 10 04 Objective: To investigate the effect of fluoxetine as an SSRI on menstrual disorders. Materials and methods: In this cross-sectional study 200 women referring to the Islamic Azad University affiliated hospitals during March 2011- March 2010 were divided into 4 groups. All included patients in this study had the chief complaint of mood disorders in peri- menstrual period. All patients received daily vitamin B6 tablets as primitive treatment. In groups A, B and C patients also received daily doses of 10 mg, 20 mg and 40 mg of fluoxetine respectively for 6 months and in group D as the control group fluoxetine was not given. Data were analyzed by spss18 statistical software. Significant difference was set at p<0.05. Results: In the groups receiving fluoxetine (groups A - C) 34 patients and in control group 5 patients showed irregular menstruation started during fluoxetine administration and following 3 months. Significant difference with p<0.05 was found regarding the incidence of menstrual irregularity between groups with and without fluoxetine prescription. Conclusion: Fluoxetine consumption leads to increased incidence of menstrual irregularity compared to the control group. The incidence increases with increasing dosage of the drug. https://jfrh.tums.ac.ir/index.php/jfrh/article/view/150 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/150/150