Tehran University of Medical Sciences Journal of Family and Reproductive Health 1735-8949 13 2 2019 11 03 98 108 Samuel Offor Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, UyoAkwa Ibom State, Nigeria Herbert Mbagwu Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, UyoAkwa Ibom State, Nigeria Orish Orisakwe Department of Experimental Pharmacology and Toxicology, Faculty of Pharmacy, University of Port-Harcourt, Rivers State, Nigeria AND World Bank Africa Centre of Excellence in Public Health and Toxicological Research (PUTOR), University of Port Harcourt, PMB,5323 Port Harcourt, Rivers State, Nigeria 2019 02 15 2019 09 03 Objective: This study has investigated the protective role of a natural alternative, Solanum anomalum fruit extract in lead induced testicular toxicity in male albino rats. Materials and methods: Twenty-four mature male albino rats were used, divided into four groups of six rats per group. Group 1 (control rats) were given distilled water (10ml/kg), group 2 received lead acetate solution 60mg/kg, group 3 received lead acetate (60mg/kg) followed by Solanum anomalum (452mg/kg) and group 4 rats were given lead acetate (60mg/kg) followed by Solanum anomalum  (678mg/kg) by oral gavage daily for 28 days. Results: Lead treated group showed significant increase in Malondialdehyde MDA (1.58 ± 0.09 to 1.90 ± 0.17 µmol/L of plasma) and decreases in Superoxide dismutase SOD, glutathione peroxidase (482.85 ± 53.43 to 247.18 ± 70.40 U/L of blood), total glutathione (1.11 ± 0.03 to 0.56 ± 0.31 ng/µL) (144.80 ± 7.00 and 122.39 ± 4.63 U/ml of blood), epididymal sperm reserve, testicular sperm count, % sperm motility and % sperm viability. Conclusion: Co-administration of Solanum anomalum significantly reversed the effect of lead with restoration of histoarchitecture of the testes. Solanum anomalum may be a protective modulator of lead -induced testicular injury.   https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1074 https://jfrh.tums.ac.ir/index.php/jfrh/article/download/1074/487